CAS: 152828-23-4; N-(3-Tert-Butyl-5-Pyrazolyl)-4-Nitrobenzamide Oxime

📜3-(4-Nitrophenyl)-5-(2-Oxo-3,3-Dimethylbutyl)-1,2,4-Oxadiazole置于溶剂黄146,肼体系中,用 水,异丙醇 用作溶剂,化学反应 4.25H,反应生成N-(3-叔丁基-5-吡唑基)-4硝基苯胺基肟
参考文献:Wo2007/124024
标题:Wo2007/124024

专利信息

专利号:US-2009221834-A1
优先权日:2006-04-20
标题 :Synthesis of 5-Beta-Keto-1,2,4-Oxadiazoles and Conversion of 5-Beta-Keto-1,2,4 Oxadiazoles to N-Pyrazolyl Amidoximes
发明人：JENSEN DAVID R; SIDENSTICK JOHN E
权利人:JENSEN DAVID R; SIDENSTICK JOHN E
摘要:The disclosed invention relates to a process for preparing 5-β-keto-1,2,4-oxadiazoles of formula (I), and conversion of 5-β-keto-1,2,4-oxadiazoles (I) into N-pyrazolyl amidoximes of the formula (II) through reaction with hydrazine. The process is defined by two steps. An amidoxime, which may be prepared in situ, is condensed with a β-keto ester to form a 5-β-keto-1,2,4-oxadiazole. The 5-β-keto-1,2,4-oxadiazole is subsequently reacted with hydrazine to furnish the desired N-pyrazolyl amidoxime. The disclosed invention provides several advantages over the current state of the art for the synthesis of N-pyrazolyl amidoximes, which require the condensation of a pyrzolylamine with an actived substrate and subsequent reaction with hydroxyl amine. N-pyrazolyl amidoximes are useful synthetic intermediates, especially for the preparation of photographic developing chemicals.

专利号:US-6020498-A
优先权日:1998-08-04
标 题 :Process for preparing carboxamide oximes
发明人：FERRUCCIO LAURENCE; GIBERT DOMINIQUE; VERGNE GUYSELAINE
权利人:ISOCHEM SA
摘要:The invention relates to a process for preparing carboxamide oximes of the formula (I): in which R 1 represents an aryl or heteroaromatic group, and R 2 and R 3 represent a hydrogen atom or groups as defined in the description, characterized by the three following steps: n 1) An amide of the formula (II) R 1 CONHR 4 , with R 1 having the previous meaning and R 4 being a C 1 to C 8 alkyl group, is reacted with a chlorinating agent in order to obtain the corresponding chloroimine, n 2) The resulting chloroimine is then caused to react with an aminopyrazole in order to obtain a novel disubstituted amidine, n 3) The resulting amidine is caused to react with hydroxylamine or one of its salts. n Carboxamide oximes are prepared more rapidly, and in a good yield, in this way. They are useful as synthesis intermediates, in particular for preparing photographic developing agents.