CAS: 147116-67-4; (2S,3S)-2-Benzhydryl-N-(5-(Tert-Butyl)-2-Methoxybenzyl)Quinuclidin-3-Amine

上下游产品

(2-Diphenylmethyl-1-Azabicyclo[2.2.2]Oct-3-yl)-Benzylamine 155681-48-4
(-)-(2S,3S)-Cis-2-(Diphenylmethyl)-1-Azabicyclo[2.2.2]Octane-3-Amine 142035-23-2
(+)-(2S,3R)-2-(Diphenylmethyl)-1-Azabicyclo<2.2.2>Octan-3-Ol
(S)-2-Diphenylmethylquinuclidin-3-One 683206-53-3

(2S,3S)-2-Diphenylmethyl-N-((S)-1-Phenylethyl)Quinuclidin-3-Amine置于4-二甲氨基吡啶,5%-Palladium/activated Carbon,氢气,三乙胺体系中,用 N,N-二甲基甲酰胺,异丙醇 用作溶剂,化学反应 24.0H,反应生成马罗匹坦
参考文献:制备马罗匹坦游离碱的方法
标题:制备马罗匹坦游离碱的方法
摘要:本发明涉及马罗匹坦游离碱的制备方法,反应式如下:.

专利信息

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-2015158809-A9
优先权日:2013-02-26
标 题 :Method of making 1-(acyloxy)-alkyl carbamate compounds
发明人：WANG HUAN; LIU PENG; DAI QUNYING; YIN HAO; RAILLARD STEPHEN P
权利人:XENOPORT INC
摘要:Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.

专利号:EP-1713801-B1
优先权日:2004-02-02
标 题:Process for preparation of 1-(2s,3s)-2-benzhydr yl-n-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine
发明人：BASFORD PATRICIA ANN; POST RONALD JAMES; SMITH JULIAN DUNCAN; TABER GERALDINE PATRICIA
权利人:PFIZER PROD INC
摘要:This invention relates to an improved process for the preparation of (2S,3S)-­ 2-benzhydryl-N-(5-tent-butyl-2-methoxybenzyl)quinuclidin-3-amine, (hereinafter 'compound of Formula I') and its pharmaceutically acceptable salts. In particular, the invention is directed to an improved synthesis of the monohydrate citrate salt of the compound of Formula (la).

专利号:WO-2009094569-A2
优先权日:2008-01-25
标 题:Method for the enzymatic kinetic resolution of acyloxyalkyl thiocarbonates used for the synthesis of acyloxyalkyl carbamates

专利号:US-2005222431-A1
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof

专利号:US-7227028-B2
优先权日:2003-12-30
标题 :Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof