CAS: 146256-98-6; 1-Tert-Butyl 3-Ethyl 4-Oxopyrrolidine-1,3-Dicarboxylate

相似化合物

51814-19-8 916814-29-4 1027-35-6

上下游产品

3-(tert-butoxycarbonyl-ethoxycarbonylmethyl-amino)-propionic acid ethyl ester ethyl 2-(tert-butoxycarbonylamino)acetate ethyl acrylate tert-butyl dicarbonatedi-tert-butyl dicarbonate3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester (3S,4R)-1-(N-tert-butoxycarbonyl)-3-[(1'R)-phenylethylamino]pyrrolidine-4-carboxylic acid ethyl ester hydr°Chloride (3S,4S)-3-amino-4-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (3R,4S)-3-[(S)-3-(4-fluorobenzyl)-piperidine-1-carbonyl]-4-[(R)-1-phenyl-ethylamino]-pyrrolidine-1-carboxylic acid tert-butyl ester

2-氮杂丁烷-1,4-二羧酸二乙酯置于乙醇,Sodium,三乙胺体系中,用 乙醇 用作溶剂,化学反应生成N-Boc-4-氧代-3-吡咯烷甲酸乙酯
参考文献:Anti-Angiogenesis Compound,Intermediate And Use Thereof
标题:Anti-Angiogenesis Compound,Intermediate And Use Thereof
摘要:本发明揭示了一种以化学式i表示的抗异常血管生成增殖化合物,其用途和中间体.该化合物对异常血管生成的增殖具有非常好效果,其活性是通过抑制vegfr2而产生的.该化合物可用于治疗由血管生成和蛋白激酶(如vegfr2,Fgfr2等)的异常引起的疾病,如湿性黄斑变性,炎症,恶性肿瘤等.

专利信息

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:US-2009137557-A1
优先权日:2005-11-22
标题 :Calcilytic Compounds
发明人：KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
权利人:KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.