CAS: 141725-88-4; Cetefloxacin
该化合物是一种合成的氟己酮抗生素,其特点是其广泛频谱抗菌活动,主要用于兽医治疗动物细菌感染;该化合物展示了一种行动机制,包括抑制细菌DNA gyraase 和TOP异构体Asse IV, 一种对DNA复制和转录至关重要的酶.Cetefloxanci素因其对各种克型和克型阴性细菌具有效力而闻名,因此在管理感染方面是一种宝贵的选择.该物质通常通过口服或注射方式进行,取决于具体的配方和预期用途.其药理基因特性包括良好的组织吸收和分布,尽管它可能在某些菌株中受到抗药性发育的影响.安全简介表明潜在的副作用,其中可能包括胃肠扰动,在少数情况下,对幼动物的体肥料发育产生影响.与所有抗生素一样,必须负责任地使用,以减轻抗药性风险并确保治疗感染的持续效力.
物理性质
- 沸点592.0±50.0 °C(预测)
- 闪点311.8 °C
- 密度1.502±0.06 g/cm3(预测)
- pKa:6.02±0.41(预测)
- PSA:88.56
- LogP:3.4073
- 折射率1.634
- 蒸汽压7.34E-15 mmHg at 25 °C
- 外观形态固体-粉末
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用该化合物是一种广泛频谱抗菌性抗生素,其中值为0.007至8微克/毫升;对小鼠在抗ESCHERICHIA COLI,PSEUDOMONAS AERUGINOSA,STAPHYLOCOCCCUS AUREUS和STREPTOCOCUS肺炎方面具有保护作用.
MSDS等安全信息
上下游产品
6,7-difluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid合成工艺路线路线简述
📜7-Chloro-1-(2,4-Difluorophenyl)-6-Fluoro-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid,(2R,3S)-2-Methylazetidin-3-Amine;Dihydrochloride置于7-Chloro-1-(2,4-Difluorophenyl)-6-Fluoro-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid体系中,用81的收率获得西替沙星
参考文献:J. Med. Chem. 1995,38,1203-1215
标题:J. Med. Chem. 1995,38,1203-1215
海关参考信息
- 2905110000-甲醇
2912110000-甲醛
2915110000-甲酸
2921211000-乙二胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
专利号:US-2015158809-A9
优先权日:2013-02-26
标 题 :Method of making 1-(acyloxy)-alkyl carbamate compounds
发明人：WANG HUAN; LIU PENG; DAI QUNYING; YIN HAO; RAILLARD STEPHEN P
权利人:XENOPORT INC
摘要:Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.
专利号:WO-2009094569-A2
优先权日:2008-01-25
标 题:Method for the enzymatic kinetic resolution of acyloxyalkyl thiocarbonates used for the synthesis of acyloxyalkyl carbamates
专利号:US-2005222431-A1
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
专利号:US-7227028-B2
优先权日:2003-12-30
标题 :Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
专利号:US-2007244331-A1
优先权日:2003-12-30
标 题 :Synthesis of Acyloxyalkyl Carbamate Prodrugs and Intermediates Thereof
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Guzmán A, García C, Marín AP, Demestre I. Four-week oral toxicity studies of the new quinolone antibacterial agent cetefloxacin tosylate in rats and marmoset monkeys. Arzneimittelforschung. 2001;51(5):425-32. doi: 10.1055/s-0031-1300058. 38(7):1203-15. doi: 10.1021/jm00007a017.
合成参考文献
参考文献:10.1007/bf02815553
摘要:Majtánová L, Majtán V. Postantibiotic effects of imipenem and enoxacin against S. typhimurium and S. enteritidis and the influence on their surface hydrophobicity. Folia Microbiol (Praha). 1998;43(1):104–8. doi: 10.1007/bf02815553.
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