CAS: 1355031-15-0; 4-(4-Aminophenoxy)-6-Methoxyquinolin-7-Ol

英文名称4-(4-Aminophenoxy)-6-Methoxyquinolin-7-Ol
中文名称4-(4-氨基苯氧基)-6-甲氧基喹啉-7-酚
IUPAC名称4-(4-aminophenoxy)-6-methoxyquinolin-7-ol
其它别名Cabozantinib Impurity; Cabozantinib Imp; Cabozantinib Impurity Ts; 7-Quinolinol, 4-(4-Aminophenoxy)-6-Methoxy-; 4-(4-Aminophenoxy)-6-Methoxyquinolin-7-Ol; 4-(4-Aminophenoxy)-6-Methoxyquinolin-7-Olq: What Is 4-(4-Aminophenoxy)-6-Methoxyquinolin-7-Ol Q: What Is The Cas Number Of 4-(4-Aminophenoxy)-6-Methoxyquinolin-7-Ol; Cabozantinib Impurity 76; 2-((4-((6,7-Dimethoxyquinolin-4-yl)Oxy)Phenyl)Amino)-2-Oxoacetic Acid
CAS编号1355031-15-0
FDA UNII编号:VM2TS32CZK
分子式:C16H14N2O3分子量:282.3
产品CID: 553046
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: KFKLTMXLCRLEBX-UHFFFAOYSA-N
InChI=1S/C16H14N2O3/c1-20-16-8-12-13(9-14(16)19)18-7-6-15(12)21-11-4-2-10(17)3-5-11/h2-9,19H,17H2,1H3
计算化学: 氢键受体数5.0氢键供体数2.0可旋转键数3.0

MSDS等安全信息

警示词Warning
危险描述H302-H315-H319-
防范说明P264-P270-P280-P301+P312+P330-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364-P501-

上下游产品

4-benzyloxy-3-methoxyacetophenone 1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone 1-(4-(benzyloxy)-5-methoxy-2-nitrophenyl)ethanone 7-(benzyloxy)-6-methoxy-4-(4-nitrophenoxy)quinoline N-(4-((7-hydroxy-6-methoxyquinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide ethyl 2-((4-(4-aminophenoxy)-6-methoxyquinolin-7-yl)oxy)acetate ethyl 2-[4-(4-{3,-[2-tert-butyl-4-(1-methyl-1H-pyrazol-5-yl)-1H-imidazol-5-yl]ureido}phenoxy)-6-methoxyquinolin-7-yloxy]acetate 1-[2-tert-butyl-4-(1-methyl-1H-pyrazol-5-yl)-1H-imidazol-5-yl]-3-{4-[7-(2-hydroxyethoxy)-6-methoxyquinolin-4-yloxy]phenyl}urea

合成工艺路线路线简述

📜7-苄氧基-4-羟基-6-甲氧基喹啉置于palladium 10% On Activated Carbon Potassium Formate,N,N-二异丙基乙胺,三氯氧磷体系中,用甲醇,水,甲苯,Xylene 用作溶剂,化学反应 14.0H,反应生成4-(4-氨基苯氧基)-6-甲氧基喹啉-7-酚
参考文献:Substituted Quinoline Compounds And Methods Of Use
标题:Substituted Quinoline Compounds And Methods Of Use
摘要:本发明提供了新型取代喹啉化合物,其药用可接受的盐和制剂,用于调节蛋白酪氨酸激酶活性,以及调节细胞活动,如增殖,分化,凋亡,迁移和侵袭.该发明还提供了包含这些化合物的药用可接受的组合物,以及在治疗哺乳动物,特别是人类的高增殖性疾病中使用这些组合物的方法.