CAS: 1264-62-6; (2S,3R,4S,6R)-4-(Dimethylamino)-2-(((3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-Ethyl-7,12,13-Trihydroxy-4-(((2R,4R,5S,6S)-5-Hydroxy-4-Methoxy-4,6-Dimethyltetrahydro-2H-Pyran-2-yl)Oxy)-3,5,7,9,11,13-Hexamethyl-2,10-Dioxooxacyclotetradecan-6-yl)Oxy)-6-Methyltetrahydro-2H-Pyran-3-Yl Ethyl Succinate

该化合物是一种抗生素,主要用于治疗各种细菌感染,主要用于治疗各种细菌感染的大型硅酸乙酯是一种抗生素,它是红血素的半合成衍生物,可增强其稳定性和生物利用率;该化合物的特征是,它能够抑制细菌蛋白合成,与50S的脊髓炎亚元素结合,使其对一系列的抗乳阳性细菌和某些抗腺阴性细菌有效;乙基氨酸乙酯一般是口服的,并往往配制成一种治疗药物,在身体中转化成红血素;它以相对较低的毒性和副作用闻名而闻名,尽管胃肠扰动可能发生;该物质在有机溶剂中溶解,但水溶性有限,影响其配制和投送;此外,在临床环境中使用这种抗生素时必须考虑潜在的药物相互作用和抗药性模式.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号14794-31-1 丁二酸单乙酯酰氯 | CAS号114-07-8 红霉素

合成工艺路线路线简述

    丁二酸单乙酯酰氯,红霉素置于碳酸氢钠,丙酮体系中,化学反应生成琥乙红霉素
    参考文献:Clark; Varner,Antibiotics And Chemotherapy,1957,Vol. 7,P. 487
    标题:Clark; Varner,Antibiotics And Chemotherapy,1957,Vol. 7,P. 487

    海关参考信息

    专利信息


    专利号:WO-2023073242-A1
    优先权日:2021-11-01
    标题:Process and apparatus for synthesis of organic carbon compounds
    发明人:BECKER SEBASTIAN; NIEHOFF GUERRA ALEJANDRO; SCHACHT OLAF; HAID MICHAEL OLIVER
    权利人:REFUEL GREEN CONSULTING & TECH GMBH
    摘要:The invention relates to a process for synthesis of organic carbon compounds from feed gases containing carbon dioxide (CO2) and optionally hydrogen (H2) and also optionally short-chain hydrocarbons (CxHy). The invention aims to raise energetic efficiency significantly while achieving high degrees of chemical conversion. This is achieved by charging the reaction space (4) of the DBD reactor (1) with a liquid and a catalyst, establishing a temperature and pressure range in the reaction space (4), introducing the feed gases into the reaction space (4) of the DBD reactor (1), to form ascending gas bubbles in the reaction space (4), forming a non-thermal plasma in the ascending gas bubbles by applying a high AC voltage or a pulsed high voltage between the electrode/cathode (5) and a counter-electrode/anode (11) surrounding the outer wall (2), converting the constituents of the supplied feed gases into reaction products and reaction intermediates by endothermic reactions in the gas/plasma bubbles, preparing organic carbon compounds in exothermic reactions by means of one or more catalysts in the liquid phase after the diffusion of the reaction products/intermediates into the liquid phase, by utilizing the liquid in the electrical discharge space of the DBD reactor additionally for exothermic thermocatalytic synthesis reactions in the liquid phase, including all the phase interfaces, using a catalyst, and withdrawing/discharging the reaction products prepared, such as hydrocarbons, in a product stream (12) from the DBD reactor.

    专利号:EP-1775261-B1
    优先权日:2005-10-11
    标 题:Synthesis of carbon nanotubes and/or nanofibres on a polymer substrate
    发明人:MEZZO LUCA; GAIO ANDREA; CESANO FEDERICO; SCARANO DOMENICA; ZECCHINA ADRIANO
    权利人:FIBRE E TESSUTI SPECIALI S P A
    摘要:The method provides for the synthesis of carbon nanotubes and/or nanofibres on the surface of a polymer substrate selected from the group consisting of polybenzoxazoles, polybenzimidazoles, polyimides, polyaramides and mixtures thereof. The method comprises the steps of: depositing on the surface of the substrate at least one metal belonging to one of groups Ib to VIIIb of the Periodic Table of Elements, which metal has catalytic properties with respect to the formation and development of the carbon nanotubes and/or nanofibres, and placing the substrate in contact with a gas comprising a component the molecule of which contains at least one carbon atom, at a temperature of between 400 and 900°C, so as to bring about the synthesis of the carbon nanotubes and/or nanofibres on the surface of the polymer substrate.

    专利号:WO-2013178803-A1
    优先权日:2012-05-31
    标 题:Process and apparatus for the electrolytic synthesis of methanol and/or methane
    发明人:SCHAEL OLIVER; BURMEISTER GUIDO
    权利人:HETTICH HOLDING GMBH & CO OHG
    摘要:The invention relates to a process for the electrolytic synthesis of methanol by reduction of carbon dioxide present in an electrolyte in the liquid phase, at the critical point or in the supercritical phase of the electrolyte. The process is characterized in that protons for the reduction of the carbon dioxide are introduced into the electrolyte via a proton-conducting membrane (2). The invention further relates to an apparatus suitable for carrying out the process.

    专利号:US-8557979-B2
    优先权日:2004-06-10
    标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation
    发明人:CHOI WOO-BAEG; KOWALIK EWA
    权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC
    摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

    专利号:US-10933051-B2
    优先权日:2017-06-09
    标 题 :Carbapenem compounds and compositions for the treatment of bacterial infections
    发明人:CHOI WOO-BAEG; TOMIOKA TAKASHI; JOO HYUNG-YEUL; TRUONG PHONG; MIN BRIAN
    权利人:FOB SYNTHESIS INC
    摘要:The present invention provides carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections, including drug resistant or multiple-drug resistant bacterial infections, and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

    专利号:US-9693999-B2
    优先权日:2011-01-26
    标题:Small molecule RNase inhibitors and methods of use
    发明人:DUNMAN PAUL M; OLSON PATRICK D; CHILDERS WAYNE
    权利人:UNIV ROCHESTER; UNIV NEBRASKA; Temple University—Of the Commonwealth System of Higher Education
    摘要:Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.
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    主要参考文献


    1: Stan CD, Stefanache A, Tântaru G, Poiată A, Dumitrache M, Diaconu DE, Profire L. Posibilităţi de obtinere a etil-succinatului de eritromicină [Erythromycin ethylsuccinate obtaining possibilities]. Rev Med Chir Soc Med Nat Iasi. 2008 Oct-Dec;112(4):1104-9. Romanian. 76(5 Pt 1):1007-8. 55(3):675-83. doi: 10.1007/s10620-009-1038-3. 3(2):189-95. 3(2):e00103-18. doi: 10.1128/mSphere.00103-18.
    6: Gu Y, Wang G, Sun J. Simultaneous determination of erythromycin ethylsuccinate and its metabolite erythromycin in human plasma using liquid chromatography-electrospray ionization mass spectrometry for clinical study. J Pharm Biomed Anal. 2006 Feb 24;40(3):737-43. doi: 10.1016/j.jpba.2005.11.005. Epub 2006 Jan 10. 25(1):36-42. doi: 10.1002/j.1552-4604.1985.tb02798.x. 32(4):561-5. doi: 10.1128/aac.32.4.561.
    9: Sullivan D, Csuka ME, Blanchard B. Erythromycin ethylsuccinate hepatotoxicity. JAMA. 1980 Mar 14;243(10):1074. 14(2):157-63. doi: 10.1093/jac/14.2.157. 32(8):1227-30. doi: 10.1128/aac.32.8.1227.

    合成参考文献


    摘要:Drugs in Japan, 6(126), 1982
    摘要:Miller, R. R., and D. J. Greenblatt. Handbook of Drug Therapy. New York: Elsevier North Holland, 1979., p. 54
    摘要:Miller, R. R., and D. J. Greenblatt. Handbook of Drug Therapy. New York: Elsevier North Holland, 1979., p. 56
    摘要:SRI. 1989 Directory of Chemical Producers -United States of America. Menlo Park, CA: SRI International, 1989., p. 749
    参考文献:10.1016/0731-7085(96)01776-1
    摘要:Amin AS, Issa YM. Selective spectrophotometric method for the determination of erythromycin and its esters in pharmaceutical formulations using gentiana violet. Journal of Pharmaceutical and Biomedical Analysis. 1996 Aug;14(11):1625–9. doi: 10.1016/0731-7085(96)01776-1.
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