CAS: 1070-65-1; Ethyl 8-Chloro-6-Hydroxyoctanoate

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CAS号626-86-8 己二酸单乙酯 | CAS号1070-64-0 6,8-二氯辛酸乙酯

📜己二酸单乙酯置于aluminum (III) Chloride,氯化亚砜,钾硼氢,Potassium Carbonate体系中,用 乙醇,水,1,2-二氯乙烷 用作溶剂,化学反应 7.0H,反应生成6-羟基-8-氯辛酸乙酯
参考文献:一种6,8-二氯辛酸乙酯的制备方法
标题:一种6,8-二氯辛酸乙酯的制备方法
摘要:本发明涉及一种6,8‑二氯辛酸乙酯的制备方法,属于药物合成技术领域.制备方法为(1)将式ⅱ化合物与二氯亚砜反应得到式ⅲ化合物;(2)式ⅲ化合物在三氯化铝存在下,通入乙烯气体,反应完毕后,滴加化学计量的水,使三氯化铝以六水合三氯化铝的形式析出,离心分离后得含式ⅳ化合物的溶液;(3)使式ⅳ化合物在碱存在下与还原剂反应,得到式ⅴ化合物;(4)使式ⅴ化合物和二氯亚砜在催化剂存在下,加热反应,得到6,8‑二氯辛酸乙酯.本发明在制备式ⅳ化合物时,通过加入化学计量的水淬灭反应,使三氯化铝反应成六水合三氯化铝直接从反应中析出,只需要简单的过滤或离心即可进行下一步反应,大大减少了废水排放量.

专利信息

专利号:CN-110004119-B
优先权日:2019-04-18
标 题:ε-Ketoester reductase mutants and their application in the synthesis of (R)-α-lipoic acid precursors

专利号:CN-119776302-A
优先权日:2024-04-03
标题:Alcohol dehydrogenase mutants and their application in the synthesis of high optical purity (S)-6-hydroxy-8-chlorooctanoic acid ethyl ester

专利号:CN-116283570-A
优先权日:2023-03-27
标 题 :One-pot Synthesis of 6,8-Dichlorooctanoate

专利号:WO-2007028729-A1
优先权日:2005-09-10
标题:Nocardia globerula alcohol dehydrogenase and use thereof
发明人：HUMMEL WERNER; SCHUEMERS JULIA; GROEGER HARALD
权利人:DEGUSSA; HUMMEL WERNER; SCHUEMERS JULIA; GROEGER HARALD
摘要:The present invention concerns a Nocardia globulera alcohol dehydrogenase. The invention relates to novel polypeptides having an alcohol dehydrogenase activity, to nucleic acids encoding these polypeptides, to primers or probes for preparing the nucleic acid sequences, to non-human hosts or host cells and to reaction systems that can be used to prepare desired products. Co-factor-dependent alcohol dehydrogenases of this kind can be used advantageously to obtain alcohols, in particular enantiomerically enriched alcohols, which may be useful when employed in organic synthesis, by using a co-factor- regenerating enzyme in a coupled enzymatic system. Alternatively, it is also possible to employ the polypeptides of the invention for the reverse reaction, i.e. oxidation of alcohols with formation of carbonyl compounds.