CAS: 103-32-2; N-Phenylbenzylamine

相似化合物

3422-01-3 404-24-0 542-11-0

上下游产品

N-(对氯苄基)苯胺 N-(P-Chlorobenzyl)Aniline 4750-61-2
对苄氨基苯酚 4-(Benzylamino)Phenol 103-14-0
N,N-甲基苄基苯胺 N-Methyl-N-Phenyl-Benzenemethanamine 614-30-2
N-苯基-4-甲氧基苄胺 N-(4-Methoxybenzyl)Aniline 3526-43-0
硫苯甲醯胺苯 N-Phenylbenzothioamide 636-04-4
N-苄基-N-苯基羟胺 N-Benzyl-N-Phenylhydroxylamine 3376-40-7
N-苄基-2-碘苯胺 N-Benzyl-2-Iodoaniline 76464-99-8
N-(2-碘苯基甲基)苯胺 N-(2-Iodobenzyl)Aniline 76464-90-9 N-Phenyl Benzoyl Amide 93-98-1 N-Benzyl-2-Chloroaniline 98018-66-7

1,2-二苯肼置于正丁基锂,Titanium(III) Chloride,水体系中,用 四氢呋喃,正己烷 用作溶剂,化学反应 4.25H,反应生成苯甲基苯胺
参考文献:三氯化 钛(III)的水溶液将肼还原为胺†
标题:三氯化 钛(III)的水溶液将肼还原为胺†
摘要:肼中n-n键的裂解被广泛用于胺的制备中,因此在有机合成中占有重要地位.在本文中,我们报告了一种新的方法,该方法可通过市售廉价的水溶液还原肼中的n-n键三氯化钛.反应可在从酸性到中性和碱性的宽ph范围内顺利进行,从而以非常好的收率获得胺.此方法与包含官能团的底物兼容,例如,Cc双键,苄基-氮键,苄氧基和酰基.
Doi:10.1039/c1Ob05328K

专利信息

专利号:US-8642809-B2
优先权日:2007-09-25
标 题:Methods of synthesis of certain hydroxamic acid compounds
发明人：REISCH HELGE A; LEEMING PETER; RAJE PRASAD S
权利人:REISCH HELGE A; LEEMING PETER; RAJE PRASAD S; TOPOTARGET UK LTD
摘要:The present invention pertains to the general field of chemical synthesis, and more particularly to methods for the synthesis of certain hydroxamic acid compounds, and in particular, (E)-N-hydroxy-3-(3-phenylsulfamoyl-phenyl)-acrylamide, also known as PXD101 and Belinostat®, comprising, for example, the steps of: (SAF) sulfonamide formation; (PUR C ) optional purification; (AAA) alkenyl-acid addition, comprising: either (i): the steps of, in order: (ACAEA) alkenyl-carboxylic acid ester addition; (PUR E ) optional purification; and (CAD) carboxylic acid deprotection; or (ii): the step of: (ACAA) alkenyl-carboxylic acid addition; (PUR F ) optional purification; (HAF) hydroxamic acid formation; and (PUR G ) optional purification.

专利号:US-8703952-B2
优先权日:2008-12-12
标题:Synthesis of 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline and analogues and intermediates
发明人：WILLIAMSON CRAIG; STOREY JOHN MERVYN DAVID
权利人:WILLIAMSON CRAIG; STOREY JOHN MERVYN DAVID; WISTA LAB LTD
摘要:The present invention pertains generally to methods of preparing certain 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline compounds and their analogues, and especially to methods of preparing dimebon. The present invention also pertains to methods of preparing certain intermediate compounds which find use in the synthesis of the 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline compounds.

专利号:US-7557099-B2
优先权日:2004-03-01
标题 :Pyrrolobenzodiazepines as key intermediates in the synthesis of dimeric cytotoxic pyrrolobenzodiazepines
发明人：HOWARD PHILIP WILSON; KANG GYOUNG-DONG
权利人:SPIROGEN LTD
摘要:Compounds and a method of synthesis of compounds of formula (Ia) or (Ib): and salts, solvates, and chemically protected forms thereof, wherein the dotted lines indicate the optional presence of a double bond between C1 and C2 or C2 and C3; R 2 and R 3 are independently selected from —H, â•?O, â•?CH 2 , —CN, —R, OR, halo, â•?CH—R, O—SO 2 —R, CO 2 R and COR; R 10 is a carbamate-based nitrogen protecting group; and R 11 is an oxygen protecting group.

专利号:US-4620015-A
优先权日:1981-12-28
标题:Synthesis of β-((2-methylpropoxy)methyl)-N-phenyl-N-(phenylmethyl)-1-pyrrolidineethanamine
发明人：STIEFEL FRANK J
权利人:CARTER WALLACE
摘要:A novel, efficient, economical procedure for the synthesis of ethers of n-propanoldiamine having the formula: ##STR1## wherein R is a straight or branched chain lower alkyl group or an aralkyl group, Ar is an aromatic group, Ar 1 is an aromatic or heterocyclic group, A is a tertiary aliphatic, cycloaliphatic or heterocyclic amino group and addition salts thereof with pharmacologically acceptable acids.

专利号:US-2013012706-A1
优先权日:2010-03-01
标 题 :Methods and Intermediates for the Synthesis of 4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazines
发明人：HUMMERSONE MARC GEOFFERY; COUSIN DAVID
权利人:PHARMINOX LTD; HUMMERSONE MARC GEOFFERY; COUSIN DAVID
摘要:The present invention provides a compound of general formula (II), or a salt or solvate thereof: n n n n n n n n n n n n wherein n A is independently -A 1 , -A 2 , -A 3 , -A 4 , -A 5 , -A 6 , or -A 7 , wherein:n -A 1 is independently C 5-12 heteroaryl, and is optionally substituted; -A 2 is independently thioamido or substituted thioamido; -A 3 is independently imidamido, substituted imidamido, N-hydroxyimidamido, or substituted N-hydroxyimidamido; -A 4 is independently hydroxamic acid or hydroxamate; -A 5 is independently carboxamide or substituted carboxamide; -A 6 is independently aliphatic C 2-6 alkenyl, and is optionally substituted; and -A 7 is independently carboxy or C 1-4 alkyl-carboxylate;n nand its use in the synthesis of temozolomide and analogues thereof.

专利号:US-11897914-B2
优先权日:2021-11-29
标题 :Synthesis of 2′ protected nucleosides
发明人：POON WING C; ZOU RUIMING; LAU ALDRICH N K; YU DAVID; Du Gengyu; YAO YUN-CHIAO; ZHAO GANG
权利人:HONGENE BIOTECH CORP
摘要:Embodiments of the present application relate to the preparation of 2′-O-protected nucleoside phosphoramidites and conjugation of the 2′-O-protected nucleoside to a solid support. More specifically, the present application relates to nucleosides having a hydroxy protecting group at the 2′ position that reduces migration to the 3′ position during RNA (e.g., mRNA) synthesis and can be readily removed under mild conditions without the use of toxic metal-containing reagents. Methods of using the nucleosides described herein in RNA synthesis are also disclosed.