CAS: 99071-54-2; 6-Aminomethylquinoline

相似化合物

1185694-50-1 5382-43-4 179873-36-0

上下游产品

6-(Azidomethyl)Quinoline
6-喹啉羧酰胺 Quinoline-6-Carboxamide 5382-43-4
喹啉-6-甲腈 Quinoline-6-Carbonitrile 23395-72-4
6-羟甲基喹啉 6-(Hydroxymethyl)Quinoline 100516-88-9
6-氯甲基喹啉 6-(Chloromethyl)Quinoline 2644-82-8
喹啉-6-羧酸 Quinoline-6-Carboxylic Acid 10349-57-2
6-喹啉羧酸甲酯 6-(Methoxycarbonyl)Quinoline 38896-30-9

6-氯甲基喹啉 以 Ammonium Hydroxide 作为反应溶剂,化学反应生成 6-氨基甲基喹啉
参考文献:Substituted Alkylamine Derivatives And Methods Of Use
标题:Substituted Alkylamine Derivatives And Methods Of Use
摘要:选择的胺类化合物对于预防和治疗疾病,如介导血管反应生成的疾病,具有有效性.该发明涵盖了新颖的化合物,类似物,前药及其药用可接受的盐,用于预防和治疗涉及癌症等疾病和其他疾病或病况的药物组合物和方法.该发明还涉及制备这类化合物的方法,以及在这类方法中有用的中间体.

专利信息

专利号:WO-2009117985-A1
优先权日:2008-06-12
标题 :Pirinixic acid derivatives as prostglandin e2 synthesis inhibitors for treating inflammatory diseases
发明人：WERZ OLIVER; KOEBERLE ANDREAS; SCHUBERT-ZSILAVECZ MANFRED; POPESCU LAURA; SYHA YVONNE
权利人:MEDEON PHARMACEUTICALS GMBH; UNIV TUEBINGEN; WERZ OLIVER; KOEBERLE ANDREAS; SCHUBERT-ZSILAVECZ MANFRED; POPESCU LAURA; SYHA YVONNE
摘要:The invention relates to pirinixic acid derivatives, especially a-substituted pirinixic acids and pirinixic acid esters, and the structural derivatives thereof with the following structural formula. The pirinixic acid derivatives inhibit the PGE2 synthesis, especially that of the mPGES-1. The invention also relates to the use of said pirinixic acid derivatives for producing a medicament for treating prostaglandin E2-mediated diseases, especially inflammatory diseases, painful and feverish conditions, cardiovascular events and cancerous diseases associated with an increased inducible microsomal prostaglandin E2 synthesis-1 (mPGES-1) activity or increased prostaglandin E2 synthesis.