CAS: 95-89-6; 3-Chloro-2,5-Dimethylpyrazine

该化合物是属于双子宫的有机化合物,其特点是五人芳香环,含有两个氮原子,该化合物的特点是氯原子和配有双子环的两个甲基组,特别是3,2和5个位置,典型的是一种无色的黄色黄色液体,有独特的气味,经常被称为土质或坚果;氯原子的存在有助于其再活动,使其在各种化学合成和应用中有用;3-Croloo-2,5-二甲基丙烯氨在有机溶剂中溶解,在水中溶解程度有限;主要用于调味和香味工业,因其独特的芳香特征而成为香味剂;此外,它可能被用于制药和农用化学;与许多氯化化合物一样,必须谨慎地处理它,因为其潜在的毒性和环境问题.在与该物质打交道时,应注意采取适当的安全措施.

英文名称3-Chloro-2,5-Dimethylpyrazine
中文名称3-氯-2,5-二甲基吡嗪
IUPAC名称3-chloro-2,5-dimethylpyrazine
其它别名2,5-二甲基-3-氯吡嗪; 3-Chloro-2,5-Dimethyl-Pyrazine
CAS编号95-89-6
MFCD编号:MFCD00006143
EINECS号:202-463-6
FDA UNII编号:T2GK7ZW2ED
分子式:C6H7ClN2
分子量:142.59
产品CID: 2013334
产品分类有机原料→分子砌块→芳杂环类化合物→吡嗪类化合物

相似结构搜索
InChIKey: NNBALVIZMGWZHS-UHFFFAOYSA-N
InChI=1S/C6H7ClN2/c1-4-3-8-5(2)6(7)9-4/h3H,1-2H3…
计算化学: 氢键受体数2.0氢键供体数0可旋转键数0

相似化合物

27023-19-4 95-58-9 38557-71-0

MSDS等安全信息

GHS符号GHS07
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
安全声明24/25
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

6890-37-5 = 95-89-6
反应条件:1.1 Reagents: Phosphorus Oxychloride Solvents: Phosphorus Oxychloride; 3 H,Reflux1.2 Reagents: Sodium Hydroxide Solvents: Water; Neutralized,0 °C
标题:The Chafer Pheromone Buibuilactone And Ant Pyrazines Are Also Produced By Marine Bacteria
作者:Dickschat,Jeroen S.; Wagner-Doebler,Irene; Schulz,Stefan
参考文献:Journal Of Chemical Ecology 日期:2005 卷标:31(4) 页码:925-947]

6890-37-5 = 95-89-6
反应条件:1.1 Reagents: Phosphorus Oxychloride Catalysts: Sulfuric Acid,Water; 50 - 60 °C; 3 H,50 - 60 °C1.2 Reagents: Water; Cooled1.3 Reagents: Potassium Carbonate Solvents: Water; Ph 9
标题:The Discovery Of 2-Hydroxymethyl-3-(3-Methylbutyl)-5-Methylpyrazine: A Semiochemical In Orchid Pollination
作者:Bohman,Bjorn; Jeffares,Lynne; Flematti,Gavin; Phillips,Ryan D.; Dixon,Kingsley W.; Et Al
参考文献:Organic Letters 日期:2012 卷标:14(10) 页码:2576-2578]

930-62-1 = 95-89-6 [标题:Reaction Conditions
标题:Reactions Of Halomethanes In The Vapor Phase. Part 4. The Reactions Of Imidazoles With Chloroform At 500°C,And A Comparison With Their Liquid-Phase Reactions With Trichloroacetate Ion Or Hexachloroacetone And Base
作者:Busby,Reginald E.; Khan,Mohammad A.; Khan,Mohammad R.; Parrick,John; Shaw,C. J. Granville; Et Al
参考文献:Journal Of The Chemical Society 日期:1980 卷标:(7) 页码:1427-30]

6890-37-5 = 95-89-6
反应条件:1.1 Reagents: Phosphorus Oxychloride Solvents: Toluene; Rt -> 70 °C; 70 °C -> Reflux; 30 Min,Reflux1.2 Reagents: Water; 1 H,Cooled
标题:A Process For Preparing 3-Chloro-2,5-Dimethyl-Pyrazine
参考文献:China]

930-61-0 = 95-89-6 [标题:Reaction Conditions
标题:Reactions Of Halomethanes In The Vapor Phase. Part 5. The Reactions Of Imidazolines,Anils,And 1-Methylimidazole With Chloroform At 550°C,And A Comparison With Their Liquid-Phase Reactions With Trichloroacetate Ion Or Hexachloroacetone And Base
作者:Busby,Reginald E.; Khan,Mohammad A.; Khan,Mohammad R.; Parrick,John; Shaw,C. J. Granville
参考文献:Journal Of The Chemical Society 日期:1980 卷标:(7) 页码:1431-5]

= 95-89-6 [标题:Reaction Conditions
标题:Product Class 14: Pyrazines
作者:Sato,N.
参考文献:Science Of Synthesis 日期:2004 卷标:16 页码:751-844]

127605-70-3 = 95-89-6 + 27023-19-4
反应条件:1.1 Reagents: Phosphorus Oxychloride
标题:Preparation And Reactions Of Some Substituted Pyrazine Di-N-Oxide
作者:Blake,K. W.; Sammes,Peter G.
参考文献:Journal Of The Chemical Society [section] C: Organic 日期:1970 卷标:(8) 页码:1070-3]

6890-37-5 = 95-89-6
反应条件:1.1 Reagents: Phosphorus Oxychloride; Cooled; 6 H,Reflux1.2 Reagents: Water; Cooled1.3 Reagents: Sodium Hydroxide Solvents: Water; Basified
标题:Pyrazine Biosynthesis In Corynebacterium Glutamicum
作者:Dickschat,Jeroen S.; Wickel,Susanne; Bolten,Christoph J.; Nawrath,Thorben; Schulz,Stefan; Et Al
参考文献:European Journal Of Organic Chemistry 日期:2010 卷标:(14) 页码:2687-2695]

6890-37-5 = 95-89-6
反应条件:1.1 Reagents: Phosphorus Oxychloride; 30 Min,60 °C; Cooled1.2 Reagents: Sodium Hydroxide Solvents: Water; Basified,Cooled
标题:Pheromone Synthesis. Part 261: Synthesis Of Four Pyrazines Produced By Females Of The Korean Apricot Wasp,Eurytoma Maslovskii
作者:Mori,Kenji; Yang,Chang Yeol
参考文献:Tetrahedron 日期:2017 卷标:73(32) 页码:4766-4769]

5625-46-7 = 95-89-6
反应条件:1.1 Reagents: Phosphorus Oxychloride
标题:Syntheses And Reactions Of Some 2,5-Disubstituted Pyrazine Monoxides
作者:Ohta,Akihiro; Akita,Yasuo; Hara,Miyoko
参考文献:Chemical & Pharmaceutical Bulletin 日期:1979 卷标:27(9) 页码:2027-41]

6890-37-5 = 95-89-6
反应条件:1.1 Reagents: Phosphorus Oxychloride Solvents: Phosphorus Oxychloride; Cooled; 6 H,Reflux1.2 Reagents: Water; Cooled1.3 Reagents: Sodium Hydroxide Solvents: Water; Basified,Rt
标题:Novel Pyrazines From The Myxobacterium Chondromyces Crocatus And Marine Bacteria
作者:Dickschat,Jeroen S.; Reichenbach,Hans; Wagner-Doebler,Irene; Schulz,Stefan
参考文献:European Journal Of Organic Chemistry 日期:2005 卷标:(19) 页码:4141-4153]

6890-38-6 = 95-89-6 [标题:Reaction Conditions
标题:Synthesis Of Pyrazine Derivatives. I. Reactions Of 2,5-Dimethylpyrazine N-Oxides With Acid Chlorides
作者:Matsuura,Kobun; Inomata,Miyoko; Oikawa,Sumiko; Jin,Kang; Itai,Takanobu
参考文献:Chemical & Pharmaceutical Bulletin 日期:1975 卷标:23(11) 页码:2913-17]

= 95-89-6 [标题:Reaction Conditions
标题:Studies On Pyrazines. Part 32. Synthesis Of Trisubstituted And Tetrasubstituted Pyrazines As Ant Pheromones
作者:Sato,Nobuhiro; Matsuura,Tomoyuki
参考文献:Journal Of The Chemical Society 日期:1996 卷标:(19) 页码:2345-2350]

= 95-89-6 [标题:Reaction Conditions
标题:Studies On Pyrazines; Part 30: Synthesis Of Aminopyrazines From Azidopyrazines
作者:Sato,Nobuhiro; Matsuura,Tomoyuki; Miwa,Naoko
参考文献:Synthesis 日期:1994 卷标:(9) 页码:931-4]

= 95-89-6 [标题:Reaction Conditions
标题:Syntheses Of Some 2-Hydroxypyrazine 1-Oxides
作者:Ohta,Akihiro; Masano,Sawako; Tsutsui,Mayumi; Yamamoto,Fusako; Suzuki,Sumie; Et Al
参考文献:Journal Of Heterocyclic Chemistry 日期:1981 卷标:18(3) 页码:555-8

3,6-二甲基-1H-吡嗪-2-酮置于五氯化磷,三氯氧磷体系中,化学反应生成 3-氯-2,5-二甲基吡嗪
参考文献:The Preparation Of Hydroxypyrazines And Derived Chloropyrazines
标题:The Preparation Of Hydroxypyrazines And Derived Chloropyrazines
摘要:
DOI:10.1021/ja01126A070

专利信息

专利号:US-6936600-B2
优先权日:1999-04-01
标题:Sorbitol dehrydrogenase inhibitors
发明人：CHU-MOYER MARGARET Y; MYLARI BANAVARA L; ZEMBROWSKI WILLIAM J
权利人:PFIZER
摘要:This invention is directed to sorbitol dehydrogenase inhibitory compounds of the formula I, n n nwherein R 1 , R 2 and R 3 are as defined in the specification. This invention is also directed to pharmaceutical compositions containing those compounds and methods of treating or preventing diabetic complications, particularly diabetic neuropathy, diabetic nephropathy, diabetic microangiopathy, diabetic macroangiopathy and diabetic cardiomyopathy by administering such compounds to a mammal suffering from diabetes and therefore at risk for developing such complications. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an aldose reductase inhibitor and to methods of treating or preventing diabetic complications therewith. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an NHE-1 inhibitor and to methods of treating cardiomyopathy and other heart-related problems therewith. This invention is also directed to certain intermediates used in the synthesis of the compounds of formula I and to processes for preparing those intermediates.

专利号:US-3113132-A
优先权日:1961-03-17
标题:Synthesis of chlorinated alkylpyrazines
发明人：BAXTER GEORGE E; LEVIS JR WILLIAM W
权利人:WYANDOTTE CHEMICALS CORP