CAS: 88349-88-6; 2-((5-Chloroquinolin-8-yl)Oxy)Acetic Acid
该化合物是农业化学中用来保护谷物作物,特别是小麦和大麦免受除草剂引起的植物毒性危害的安全剂,它的作用是加强作物的代谢解毒途径,从而减少诸如fenexaprop-P-乙基等除草剂造成的损害,氯硝基甲酯往往作为酯(例如,cloquintocet-mexyl)的配制,以提高稳定性和吸收力,其主要优势包括选择性行动,在不危害除草剂抗除草剂功效的情况下保护作物,以及同综合虫害管理系统的兼容性,该化合物因其在保持作物产量和质量的同时扩大除草剂应用窗口的能力而受到重视,它在温带谷物种植区有很好的记录.
相似化合物
16778-21-5 730949-78-7 200505-18-6物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS09;
注释: Environment - 危险类别水生慢性毒性 类别2
急性毒性 类别4(经口)
特定目标器官毒性-重复接触 类别2
严重眼损伤 类别1
特定目标器官毒性 - 单次接触 类别3
皮肤腐蚀/刺激 类别2
皮肤致敏 类别1
水生急性毒性 类别1
水生慢性毒性 类别1
严重眼刺激 类别2A - 警示词Danger
- 危险描述H411 |对水生生物有毒并具有长期持续影响.
H302 |吞咽有害.
H373 |长期或反复接触可能损害器官.
H318 |造成严重眼损伤.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H317 |可能引起皮肤过敏反应.
H400 |对水生生物毒性极大.
H410 |对水生生物毒性极大并具有长期持续影响.
H319 |造成严重眼刺激. - 防范说明P273-P391-P501
- 危险等级9
- UN编号3077.0
- 危险品标志Xn
- 包装等级Ⅲ
- 安全声明H303+H313+H333
- 危险类别码22
- WGK Germany3.0
欧盟法规
REACH注册ECHA物质C&L通报上下游产品
cloquint°Cet-mexyl 5-Chloro-8-hydroxyquinoline chloroacetic acid ethyl ((5-chloroquinolin-8-yl)oxy)acetate 24H18ClN3O3SC24H18ClN3O3S 25H18ClN3O3C25H18ClN3O3合成工艺路线路线简述
- 130-16-5 = 88349-88-6
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Dimethyl Sulfoxide,Water; 30 Min,50 - 55 °C; 1 H,55 - 60 °C1.2 Reagents: Potassium Carbonate; 30 Min,55 - 60 °C1.3 Solvents: Dimethyl Sulfoxide; 1 - 4 H,55 - 60 °C1.4 Catalysts: Hydrochloric Acid Solvents: Water; Rt -> 100 °C; 30 Min,95 - 100 °C
标题:Process Development For The Crop Safener Cloquintocet Acid
作者:Zhang,Chunming; Et Al
参考文献:Organic Process Research & Development 日期:2019 卷标:23(10) 页码:2218-2224]
130-16-5 = 88349-88-6
反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Potassium Iodide Solvents: Xylene; 1 H,140 - 144 °C; 144 °C -> 90 °C1.2 1 H,90 - 95 °C; 5 H,Reflux1.3 Reagents: Hydrochloric Acid Solvents: Water; 1 H,Ph 3 - 3.5,50 °C
标题:Synthesis And Antimicrobial Activities Of Novel 8-(1-Alkyl/alkylsulphonyl/alkoxycarbonyl-Benzimidazol-2-Ylmethoxy)-5-Chloroquinolines
作者:Chaudhari,Raju B.; Et Al
参考文献:Journal Of The Serbian Chemical Society 日期:2011 卷标:76(9) 页码:1199-1206]
105-39-5 + 130-16-5 = 88349-88-6
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Dimethyl Sulfoxide,Water; 30 Min,50 - 55 °C; 1 H,55 - 60 °C1.2 Reagents: Potassium Carbonate; 30 Min,55 - 60 °C1.3 Solvents: Dimethyl Sulfoxide; 1 - 4 H,55 - 60 °C1.4 Catalysts: Hydrochloric Acid Solvents: Water; Rt -> 100 °C; 30 Min,95 - 100 °C
标题:Process Development For The Crop Safener Cloquintocet Acid
作者:Zhang,Chunming; Et Al
参考文献:Organic Process Research & Development 日期:2019 卷标:23(10) 页码:2218-2224]
130-16-5 = 88349-88-6
反应条件:1.1 Reagents: Sodium Hydroxide,Potassium Iodide Solvents: 1,4-Dioxane; 10 Min,Rt1.2 Solvents: 1,4-Dioxane; 3 H,Reflux
标题:A Novel Two-Dimensional Lead (Ii) Coordination Polymer Based On Dinuclear Lead(Ii) Unit Containing (5-Chloro-Quinolin-8-Yloxy)Acetate
作者:Li,Jing; Et Al
参考文献:Chinese Journal Of Structural Chemistry 日期:2014 卷标:33(10) 页码:1488-1494]
105-39-5 = 88349-88-6
反应条件:1.1 Reagents: Potassium Carbonate; 30 Min,55 - 60 °C1.2 Solvents: Dimethyl Sulfoxide; 1 - 4 H,55 - 60 °C2.1 Catalysts: Hydrochloric Acid Solvents: Water; Rt -> 100 °C; 30 Min,95 - 100 °C
标题:Process Development For The Crop Safener Cloquintocet Acid
作者:Zhang,Chunming; Et Al
参考文献:Organic Process Research & Development 日期:2019 卷标:23(10) 页码:2218-2224]
105-39-5 = 88349-88-6
反应条件:1.1 Reagents: Potassium Carbonate; 30 Min,55 - 60 °C1.2 Solvents: Dimethyl Sulfoxide; 1 - 4 H,55 - 60 °C2.1 Catalysts: Hydrochloric Acid Solvents: Water; Rt -> 100 °C; 30 Min,95 - 100 °C
标题:Process Development For The Crop Safener Cloquintocet Acid
作者:Zhang,Chunming; Et Al
参考文献:Organic Process Research & Development 日期:2019 卷标:23(10) 页码:2218-2224]
= 88349-88-6
反应条件:1.1 Reagents: Potassium Carbonate; 30 Min,55 - 60 °C1.2 Solvents: Dimethyl Sulfoxide; 1 - 4 H,55 - 60 °C2.1 Catalysts: Hydrochloric Acid Solvents: Water; Rt -> 100 °C; 30 Min,95 - 100 °C
标题:Process Development For The Crop Safener Cloquintocet Acid
作者:Zhang,Chunming; Et Al
参考文献:Organic Process Research & Development 日期:2019 卷标:23(10) 页码:2218-2224]
4367-49-1 = 88349-88-6
反应条件:1.1 Reagents: Lithium Hydroxide Solvents: Methanol,Tetrahydrofuran,Water; 1 H,Reflux1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 3
标题:Synthesis,Structural Study And Spectroscopic Characterization Of A Quinolin-8-Yloxy Derivative With Potential Biological Properties
作者:Romano,Elida; Et Al
参考文献:Open Journal Of Synthesis Theory And Applications 日期:2013 卷标:2(1) 页码:8-32]
88349-90-0 = 88349-88-6
反应条件:1.1 Catalysts: Hydrochloric Acid Solvents: Water; Rt -> 100 °C; 30 Min,95 - 100 °C
标题:Process Development For The Crop Safener Cloquintocet Acid
作者:Zhang,Chunming; Et Al
参考文献:Organic Process Research & Development 日期:2019 卷标:23(10) 页码:2218-2224]
130-16-5 = 88349-88-6
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Dimethyl Sulfoxide; 30 Min,50 - 55 °C; 1 H,50 - 55 °C1.2 Solvents: Dimethyl Sulfoxide; 1 H,50 °C; 1 - 2 H,50 °C1.3 Catalysts: Hydrochloric Acid Solvents: Water; 30 Min,95 - 100 °C; 95 - 100 °C
标题:Preparation Of Cloquintocet Acid
作者:Anonymous
参考文献:Ip.Com Journal 日期:2016 卷标:16 页码:1-2]
130-16-5 = 88349-88-6
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Dimethyl Sulfoxide,Water; 30 Min,50 - 55 °C; 1 H,55 - 60 °C1.2 Reagents: Potassium Carbonate; 30 Min,55 - 60 °C1.3 Solvents: Dimethyl Sulfoxide; 1 - 4 H,55 - 60 °C1.4 Catalysts: Hydrochloric Acid Solvents: Water; Rt -> 100 °C; 30 Min,95 - 100 °C
标题:Process Development For The Crop Safener Cloquintocet Acid
作者:Zhang,Chunming; Et Al
参考文献:Organic Process Research & Development 日期:2019 卷标:23(10) 页码:2218-2224]
130-16-5 = 88349-88-6
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone; 3 H,Reflux2.1 Reagents: Lithium Hydroxide Solvents: Methanol,Tetrahydrofuran,Water; 1 H,Reflux2.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 3
标题:Synthesis,Structural Study And Spectroscopic Characterization Of A Quinolin-8-Yloxy Derivative With Potential Biological Properties
作者:Romano,Elida; Et Al
参考文献:Open Journal Of Synthesis Theory And Applications 日期:2013 卷标:2(1) 页码:8-32]
= 88349-88-6
反应条件:1.1 Reagents: Potassium Carbonate; 30 Min,55 - 60 °C1.2 Solvents: Dimethyl Sulfoxide; 1 - 4 H,55 - 60 °C2.1 Catalysts: Hydrochloric Acid Solvents: Water; Rt -> 100 °C; 30 Min,95 - 100 °C
标题:Process Development For The Crop Safener Cloquintocet Acid
作者:Zhang,Chunming; Et Al
参考文献:Organic Process Research & Development 日期:2019 卷标:23(10) 页码:2218-2224]
130-16-5 = 88349-88-6
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethyl Sulfoxide,Water; 30 Min,50 - 55 °C; 1 H,55 - 60 °C2.1 Reagents: Potassium Carbonate; 30 Min,55 - 60 °C2.2 Solvents: Dimethyl Sulfoxide; 1 - 4 H,55 - 60 °C3.1 Catalysts: Hydrochloric Acid Solvents: Water; Rt -> 100 °C; 30 Min,95 - 100 °C
标题:Process Development For The Crop Safener Cloquintocet Acid
作者:Zhang,Chunming; Et Al
参考文献:Organic Process Research & Development 日期:2019 卷标:23(10) 页码:2218-2224
📜5-氯-8-羟基喹啉置于盐酸,水,Sodium Hydroxide体系中,用 二甲基亚砜 作为反应溶剂,化学反应 10.5H,反应生成 (5-氯-8-喹啉氧基)乙酸
参考文献:作物安全的氯喹酸的工艺开发
标题:作物安全的氯喹酸的工艺开发
摘要:开发了一种实用的一锅法生产(5-氯喹啉-8-酰氧基)乙酸(cqc酸),商业上称为cloquintocet,这是一种农作物安全剂,已添加到各种除草剂配方中以减少农作物的危害.该方法由(1)将5-氯-8-羟基喹啉(5-Chq)转化为其相应的钠盐5-Chq-Na与二甲基亚砜(dmso)中的50 Wt%naoh,(2)将5-氯烷基化在减压蒸馏除去水后,用2-氯乙酸甲酯形成chq-Na,反应生成cqc甲酯(cqc-Me),(3)用催化量的0.1 N Hcl(0.5 Mol%)水解cqc-Me.或0.1 Nh 2 So 4(0.25Mol%)得到cqc酸,产率＞ 90%,纯度＞ 98%.所有步骤都在一个锅中进行,只有一次隔离.还演示了dmso的恢复和重用.通过差示扫描量热法和/或加速量热法对过程的每个步骤/阶段进行反应性化学评估,以识别潜在的安全隐患.
DOI:10.1021/acs.Oprd.9B00279
海关参考信息
- 2903919090-氯苯
2905310000-1,2-乙二醇
2908191000-对氯苯酚
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2021386068-A1
优先权日:2018-11-07
标题 :Compositions comprising pyridine carboxylate herbicides and very long chain fatty acid (vlcfa) synthesis inhibitor herbicides
发明人：KISTER JEREMY; SATCHIVI NORBERT M
权利人:CORTEVA AGRISCIENCE LLC
摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a VLCFA synthesis inhibitor herbicide. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof, and (b) a VLCFA synthesis inhibitor herbicide.
专利号:US-2021352899-A1
优先权日:2018-11-07
标题 :Compositions comprising pyridine carboxylate herbicides and fatty acid and lipid synthesis inhibitor herbicides
发明人：KISTER JEREMY; SATCHIVI NORBERT M
权利人:CORTEVA AGRISCIENCE LLC
摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof.
专利号:ES-2717283-T3
优先权日:2012-07-24
标 题:Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6- (4-chloro-2-fluoro-3-methoxyphenyl) pyridine-2-carboxylic acid or a derivative thereof and herbicides inhibitors of VLCFA synthesis and synthesis of fatty acids / lipids
专利号:BR-102013018473-B1
优先权日:2012-07-24
标题 :HERBICIDAL COMPOSITIONS COMPENDIENT 4-AMINO-3-CHLORO-5-FLUORO-6- (4-CHLORO-2-FLUORO-3-ETOXYPHENYL) PYRIDINE-2-CARBOXYLIC ACID OR A DERIVATIVE OF THE SAME AND HERBICIDES INHIBITING THE SYNTHESIS OF VLCFA AND SYNTHESIS OF GRAIN ACID / LIPID, AND METHOD FOR UNDESIRABLE VEGETATION CONTROL
专利号:TW-I655905-B
优先权日:2012-07-24
标题 :Contains 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylic acid or a derivative thereof and very long chain fatty acid (VLCFA) Synthesis of herbicidal compositions with fatty acid/fat synthesis inhibiting herbicides
专利号:US-9644469-B2
优先权日:2012-07-24
标题 :Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl) pyridine-2-carboxylic acid or a derivative thereof and VLCFA and lipid synthesis inhibiting herbicides
发明人：YERKES CARLA N; MANN RICHARD K; SHIRAISHI IKUO; YANAGIYAMA SHINGO; SATCHIVI NORBERT M
权利人:DOW AGROSCIENCES LLC
摘要:A synergistic herbicidal composition containing (a) a compound of formula (I): n nor an agriculturally acceptable salt or ester thereof and (b) VLCFA and fatty acid/lipid synthesis inhibiting herbicides, including but not limited to, acetochlor, alachlor, anilofos, benfuresate, cafenstrole, dimethenamid-P, fentrazamide, indanofan, flufenacet, mefenacet, s-metolachlor, molinate, pethoxamid, pretilachlor, prosulfocarb, pyroxasulfone, thenylchlor and thiobencarb, or a salt or ester thereof, provide synergistic weed control of undesirable vegetation in direct-seeded, water-seeded and transplanted rice, cereals, wheat, barley, oats, rye, sorghum, corn or maize, sugarcane, sunflower, oilseed rape, canola, sugar beet, soybean, cotton, pineapple, pastures, grasslands, rangelands, fallowland, turf, tree and vine orchards, aquatics, plantation crops, vegetables, industrial vegetation management (IVM) or rights-of-way (ROW).
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1007/s44371-025-00089-z
摘要:Prashanth T, Lakshmi Ranganatha V, Al-Ghorbani M, Girish S, Khamees HA, Khanum SA. Design, synthesis and characterization of 8-[(1H-benzo[d]imidazol-2-yl)methoxy] quinoline derivatives as antimicrobial agents. Discov. Chem. 2025 Feb 19;2(1). doi: 10.1007/s44371-025-00089-z.
📝 需求与反馈
尽可能描述清楚需求与问题信息
