CAS: 768-93-4; 1-Iodoadamantane

该化合物是一种有机化合物,其特点是存在附着于固态结构的碘原子,这是一种多环碳氢化合物,以其独特的笼状配置而闻名;该化合物的分子分子配方为C10H13I,由于固态的固态结构,具有高度稳定性;在室内温度下,它通常是白色晶体固体,在水中溶解,但在有机溶剂中溶解程度较低;碘原子的存在具有独特的再活动性,使其在各种化学反应中发挥作用,包括核细胞替代,并成为合成其他碘化合物的前体;此外,1-iodoadamantane由于其独特的结构特性,有可能在药用化学和材料科学中发挥作用;在标准条件下,其相对低的毒性和稳定性使得它成为在不同领域进一步研究和开发的兴趣组合.

结构式图片

相似化合物

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合成工艺路线路线简述

    Toluene-4-Sulfonic Acid Adamantan-1-Yl Ester置于magnesium Iodide体系中,用 乙醚 作为反应溶剂,化学反应生成 1-吲哚金刚烷
    参考文献:Kraus,W.; Graef,H.-D.,Angewandte Chemie,1975,Vol. 87,P. 878-879
    标题:Kraus,W.; Graef,H.-D.,Angewandte Chemie,1975,Vol. 87,P. 878-879

    专利信息


    专利号:US-2008183007-A1
    优先权日:2004-10-08
    标 题 :Process For the Preparation of Alkyl Phosphinic Acids
    发明人:THELIN MATS
    权利人:ASTRAZENECA AB
    摘要:The present invention relates to a new process for the synthesis of alkyl phosphinic acids, and more particularly to a coupling reaction between an alkylhalide and a hypophosphorous acid derivative by a radical initiated reaction. The invention also relates to compounds obtainable by the method of the invention.

    专利号:US-2006159608-A1
    优先权日:2004-12-03
    标题 :Method for the use of [11C] carbon monoxide in labeling synthesis of 11C-labelled acids by photo-induced free radical carbonylation

    专利号:US-3335193-A
    优先权日:1964-12-28
    标 题:Synthesis of adamantane derivatives
    发明人:OLAH GEORGE A
    权利人:DOW CHEMICAL CO

    专利号:US-2006165590-A1
    优先权日:2004-12-17
    标 题 :Method for the use of [11C] carbon monoxide in labeling synthesis of 11C-labelled esters by photo-induced free radical carbonylation

    专利号:US-7626052-B2
    优先权日:2004-12-17
    标 题:Method for the use of [11C] carbon monoxide in labeling synthesis of 11C-labelled esters by photo-induced free radical carbonylation
    发明人:LANGSTROM BENGT; ITSENKO OLEKSIY; KIHLBERG TOR
    权利人:GE HEALTHCARE LTD
    摘要:Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with alcohols pretreated by a base are provided. The resultant carbon-isotope labeled esters are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.

    专利号:US-7667011-B2
    优先权日:2004-12-03
    标题:Method for the use of [11C] carbon monoxide in labeling synthesis of 11C-labelled acids by photo-induced free radical carbonylation
    发明人:LANGSTROM BENGT; ITSENKO OLEKSIY
    权利人:LANGSTROM BENGT; ITSENKO OLEKSIY
    摘要:Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with water pretreated by a base are provided. The resultant carbon-isotope labeled acids are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.
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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Christopher A Paddon, Et Al. Electrosynthetic Reduction Of 1-Iodoadamantane Forming 1,1'-Biadamantane And Adamantane In Aprotic Solvents: Insonation Switches The Mechanism From Dimerisation To Exclusive Monomer Formation. Ultrason Sonochem. 2007 Jul;14(5):502-508.
    [参考文献]: Juan E Argüello, Et Al. Fluorescent Quenching Of The 2-Naphthoxide Anion By Aliphatic And Aromatic Halides. Mechanism And Consequences Of Electron Transfer Reactions. J Org Chem. 2003 Mar 21;68(6):2362-8.
    [参考文献]: Robert Vícha, Et Al. [1-(1-Adamantylamino)Ethyl-Idene]Oxonium Methane-Sulfonate. Acta Crystallogr Sect E Struct Rep Online. 2009 May 20;65(Pt 6):O1307.

    合成参考文献


    摘要:Li, Y.; Xie, W.; Jiang, X., Science of Synthesis Knowledge Updates, (2016) 2, 27.
    摘要:Kantchev, E. A. B.; Organ, M. G., Science of Synthesis, (2009) 48, 87.
    摘要:Li, Y.; Xie, W.; Jiang, X., Science of Synthesis Knowledge Updates, (2016) 2, 16.
    摘要:Snaith, J. S., Science of Synthesis Knowledge Updates, (2011) 2, 243.
    摘要:Weibel, J.-M.; Blanc, A.; Pale, P., Science of Synthesis Knowledge Updates, (2018) 1, 3.
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