CAS: 7504-94-1; 2-Hydrazinylpyrimidine

相似化合物

33592-41-5 823-89-2 109-12-6

上下游产品

CAS号1722-12-9 2-氯嘧啶 | CAS号7727-37-9 氮气 | CAS号931-63-5 2-甲氧基嘧啶 | CAS号274-98-6 1,2,4-Triazolo[... | CAS号275-02-5 1,2,4-噻唑[1,5-A]嘧啶 | CAS号7461-00-9 N-(pyrimidin-2-... | CAS号65267-32-5 9-methyl-1,5,7,... | CAS号89978-00-7 5-氨基-1-(2-嘧啶基)-...

2-甲氧基嘧啶置于一水合肼体系中,化学反应生成 2-肼基嘧啶
参考文献:Chesterfield Et Al.,Journal Of The Chemical Society,1955,P. 3478,3481
标题:Chesterfield Et Al.,Journal Of The Chemical Society,1955,P. 3478,3481

专利信息

专利号:WO-2023091726-A1
优先权日:2021-11-18
标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
权利人:SYROS PHARMACEUTICALS INC
摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).

专利号:EP-3590340-B1
优先权日:2010-09-01
标 题:Intermediates for the synthesis of fungicidal pyrazoles

专利号:WO-2020226482-A1
优先权日:2019-05-09
标题:Synergistic compositions for controlling plant pathogens with chitinolytic microorganisms / organic acid combinations and method of use thereof
发明人：LAI HONG HENG
权利人:LAI HONG HENG
摘要:The present invention relates to pesticidal compositions and methods for controlling plant pathogens, particularly basal stem rot in the oil palm primarily caused by Ganoderma species. The pesticidal compositions comprising, as active components: (A) Bioactive compound derived from a whole broth culture of an chitinolyic microorganisms, wherein the bioactive compound comprises any or any combination of: chitinolyic microorganism, whole cell broths, liquid cultures, spores, pure cultures, cell fraction, substances, suspensions, supernatants, filtrates, extract or a cell-free extract thereof or metabolite thereof or isolated compounds, wherein the bioactive compound is derived from at least one chitinolyic microorganisms that degrade chitinous substrates. The said chitinolytic microorganism is bacteria belonging to genus Bacillus, Streptomyces and/or fungal genus Trichoderma; (B) at least one organic acid; and (C) at least one pesticide selected from chemical pesticides, microbial pesticides, plant defense activators, cuticle degrading enzymes, cell wall synthesis inhibitors, bacteriocins, antifungal peptides, antimicrobial preservatives, plant oil or plant extract. More specifically, this invention envisions the use of bioactive compounds and/or metabolites from chitinolyic microorganisms in combination essentially of organic acid and the compositions comprising them, in the use form as fungicides and/or insecticides, also be present as 'booster' to other pesticides results in many cases in an expension of pesticidal spectrum of activity or in a prevention of pesticide resistance development. Furthermore, in many cases, synergistic effects are obtained. In various embodiments, the organic acid consists essentially of acetic acid, preferably acetic acid from a fermentation. The formulation is typically applied to agricultural soil or plant material. In a particular, the present invention can be used in combination with a carrier selected from the plant growth nutrient, organic fertilizer or inorganic/organic mixture fertilizer. Although the following description relates almost exclusively to managing basal stem rot (BSR) disease in oil palm primarily caused by Gonoderma species. It will be appreciated by those skill in the art that the invention could be used to treat other diseases and pests of other plants, includes but is not limited to a fungus, bacteria, actinomycete, virus, insects, Acari and/or nematodes.

专利号:WO-9518186-A1
优先权日:1993-12-28
标 题 :Modular design and synthesis of aminimide containing molecules

专利号:EP-0737232-A4
优先权日:1993-12-28
标 题:MODULAR DESIGN AND SYNTHESIS OF AMINIMID-CONTAINING COMPOUNDS

专利号:ES-2971524-T3
优先权日:2010-09-01
标 题 :Intermediates for the synthesis of fungicide pyrazoles