📜2,3-Di(Bromomethyl)Naphthalene置于n-溴代丁二酰亚胺(Nbs),过氧化氢苯甲酰,Potassium Oxalate体系中,用 四氯化碳,乙醇,水 作为反应溶剂,化学反应 68.0H,反应生成 2,3-萘基二缩醛 参考文献:Arene Synthesis By Extrusion Reaction. Part 14. Synthesis Of Benzo-Fused Tetraphenylenes And Crystal Structure Of A 4:1 Clathrate Inclusion Compound Of Dibenzo[b,H]Tetraphenylene With P-Xylene 标题:Arene Synthesis By Extrusion Reaction. Part 14. Synthesis Of Benzo-Fused Tetraphenylenes And Crystal Structure Of A 4:1 Clathrate Inclusion Compound Of Dibenzo[b,H]Tetraphenylene With P-Xylene 摘要: DOI:10.1021/jo00297A043
专利号:US-5866335-A 优先权日:1994-06-24 标题:Preparation of derivatized 10,10'-substituted-9,9'-biacridine luminescent molecules and signal solutions 发明人:KATSILOMETES GEORGE W; HO PAK T 权利人:KATSILOMETES GEORGE W 摘要:The synthesis of 10,10'-substituted-9,9'-biacridine molecules and their derivatives is disclosed. These molecules are shown to catalyze the production of light by chemiluminescence in the presence of a signal solution having at a pH from about 10.0 to about 14.0, at a concentration effective for producing a chemiluminescent signal, a chelating agent, a sulfoxide, a reducing sugar, an oxidant or combination of oxidants, an alcohol and aqueous sodium tetraborate. These 10,10'-substituted-9,9'-biacridines are used alone or attached to haptens or macromolecules and are utilized as labels in the preparation of chemiluminescent, homogeneous or heterogeneous assays. They are also used in conjunction with other chemiluminescent label molecules to produce multiple analyte chemiluminescent assays.
专利号:US-2009111737-A1 优先权日:1999-05-24 标题:Novel antibacterial agents 发明人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES 权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES 摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.
专利号:US-7696386-B2 优先权日:2006-09-29 标 题:Method of producing diol, polydiol, secondary alcohol or diketone compound 发明人:HOSONO HIDEO; BUCHAMMAGARI HARITHA; TODA YOSHITAKE; HIRANO MASAHIRO; OSAKADA KOHTARO; TAKEUCHI DAISUKE 权利人:JAPAN SCIENCE & TECH AGENCY 摘要:The invention is a process of using, as a reducing agent, a 12CaO.7Al 2 O 3 electride containing electrons in a number of 10 19 or more and 2.3×10 21 cm −3 or less in its cages to subject a carbonyl compound to reductive coupling in a solvent, thereby synthesizing a diol or polydiol. The invention is also a process of reducing a ketone compound in a solvent, thereby synthesizing a secondary alcohol or diketone compound. According to the process of the invention, it is possible to synthesize a diol or polydiol, or a secondary alcohol or diketone compound through simple operations in a short period without using an expensive and harmful metal hydride or metal salt nor limiting the atmosphere for the synthesis to an inert gas atmosphere as in conventional processes.
专利号:US-2007031854-A1 优先权日:1999-02-01 标题:Novel 10,10'-substituted-9,9'-biacridilidine luminescent molecules their preparation and uses 发明人:KATSILOMETES GEORGE W 权利人:KATSILOMETES GEORGE W 摘要:Novel symmetric, uniformly symmetric and asymmetric 10,10′-substituted-9,9′-biacridines and the synthesis of such symmetric, uniformly symmetric and asymmetric 10,10′-substituted-9,9′-biacridine molecules and their derivatives is disclosed. These molecules are shown to produce light by luminescence in the presence of signals. These symmetric, uniformly symmetric or asymmetric 10,10′-substituted-9,9′-biacridines are used alone or attached to haptens or macromolecules and are utilized as labels in the preparation of iluminescent homogeneous and heterogeneous assays. They are also used in conjunction with other label molecules to produce multiple analyte assays.
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