CAS: 571189-51-0; 6-Acetyl-8-Cyclopentyl-5-Methyl-2-((5-(4-Methylpiperazin-1-yl)Pyridin-2-yl)Amino)Pyrido[2,3-D]Pyrimidin-7(8H)-One (Palbociclib Impurity)
该化合物是复杂的有机化合物,其特点是多环结构,包括一个-核核心,具有各种功能组,包括乙酰组和一个有助于其潜在生物活动的管状子,环球组的存在增加了其疏水特性,影响其溶性以及与生物膜的相互作用;该化合物可能具有特定的药理特性,使其对医药化学感兴趣,特别是治疗剂的研制;其分子结构表明它可能与生物目标发生相互作用,可能涉及酶抑制或受体调节;化学数据库中的化学化学物质编号571189-51-0,独特识别了该物质,便利了研究和开发工作;总体而言,该化合物的复杂结构和功能组将其定位为进一步调查药物发现和开发的候选体.
- 英文名称6-Acetyl-8-Cyclopentyl-5-Methyl-2-((5-(4-Methylpiperazin-1-yl)Pyridin-2-yl)Amino)Pyrido[2,3-D]Pyrimidin-7(8H)-One (Palbociclib Impurity)
- 中文名称6-乙酰基-8-环戊基-5-甲基-2-((5-(4-甲基哌嗪-1-基)吡啶-2-基)氨基)吡啶并[2,3-d]嘧啶-7(8H)-酮(帕布昔利布杂质)
- IUPAC名称6-acetyl-8-cyclopentyl-5-methyl-2-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one
- 其它别名Palbociclib Impurity 87; 6-Acetyl-8-Cyclopentyl-5-Methyl-2-((5-(4-Methylpiperazin-1-yl)Pyridin-2-yl)Amino)Pyrido[2,3-D]Pyrimidin-7(8H)-One; Palbociclib Impurity 32/pyrido[2,3-D]Pyrimidin-7(8H)-One,6-Acetyl-8-Cyclopentyl-5-Methyl-2-[[5-(4-Methyl-1-Piperazinyl)-2-Pyridinyl]Amino]; Pyrido[2,3-D]Pyrimidin-7(8H)-One, 6-Acetyl-8-Cyclopentyl-5-Methyl-2-[[5-(4-Methyl-1-Piperazinyl)-2-Pyridinyl]Amino]-; N-Methyl Palbociclib; 6-Acetyl-8-Cyclopentyl-5-Methyl-2-((5-(4-Methylpiperazin-1-yl)Pyridin-2-yl)Amino)Pyrido[2,3-D]Pyrimidin-7(8H)-One (Palbociclib Impurity); Pabucilib Impurity 42; 6-Acetyl-8-Cyclopentyl-5-Methyl-2-((5-(4-Methylpiperazin-1-yl)Pyridin-2-yl)Amino)Pyrido[2,3-D]Pyrimidin-7(8H)-One(N-Methyl Palbociclib)
- CAS编号571189-51-0
- FDA UNII编号:SYT54F7Y9L
- 分子式:C25H31N7O2分子量:461.57
- 产品CID: 1545842
- 产品分类首页→产品中心
物理性质
MSDS等安全信息
上下游产品
帕布昔利布 Pd 0332991 571190-30-28-Cyclopentyl-6-(1-Ethoxyvinyl)-5-Methyl-2-[5-(4-Methyl-Piperazin-1-yl)Pyridin-2-Ylamino]-8H-Pyrido[2,3-D]Pyrimidin-7-One 571189-50-9
(1-{6-[8-Cyclopentyl-6-(1-Ethoxyvinyl)-5-Methyl-7-Oxo-7,8-Dihydropyrido[2,3-D]Pyrimidin-2-Ylamino]Pyridin-3-Yl}Pyrrolidin-3-yl)Carbamic Acid Tert-Butyl Ester 571189-52-1
合成工艺路线路线简述
📜8-Cyclopentyl-6-(1-Ethoxyvinyl)-5-Methyl-2-[5-(4-Methyl-Piperazin-1-yl)Pyridin-2-Ylamino]-8H-Pyrido[2,3-D]Pyrimidin-7-One置于盐酸体系中,用 乙醇,氯仿 作为反应溶剂,化学反应生成 帕布昔利布杂质26(单体)
参考文献:2-(Pyridin-2-Ylamino)-Pyrido[2,3-D]Pyrimidin-7-Ones
标题:2-(Pyridin-2-Ylamino)-Pyrido[2,3-D]Pyrimidin-7-Ones
摘要:这项发明提供了用于治疗细胞增殖性疾病的取代2-氨基吡啶.本发明的新化合物是cyclin-Dependent激酶4 (Cdk4)的有效抑制剂.
海关参考信息
- 2912110000-甲醛
2912120000-乙醛
2921211000-乙二胺
2933310010-吡啶 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1021/jm049354h
摘要:Toogood PL, Harvey PJ, Repine JT, Sheehan DJ, VanderWel SN, Zhou H, Keller PR, McNamara DJ, Sherry D, Zhu T, Brodfuehrer J, Choi C, Barvian MR, Fry DW. Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6. J Med Chem. 2005 Apr 07;48(7):2388–406. doi: 10.1021/jm049354h.
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