CAS: 517-82-8; Echinochrome A
- 英文名称Echinochrome A
- 中文名称海胆色素 A
- IUPAC名称2-ethyl-3,5,6,7,8-pentahydroxynaphthalene-1,4-dione
- 其它别名1,4-Naphthoquinone,2-ethyl-3,5,6,7,8-pentahydroxy- (7CI,8CI); 2-Ethyl-3,5,6,7,8-pentahydroxy-1,4-naphthoquinone; Echin°Chrome; Echin°Chrome1; Echin°Chrome A
- CAS编号517-82-8
- MFCD编号:MFCD03791011
- FDA UNII编号:J4L83T8MZ5
- 分子式:C12H10O7分子量:266.2
- 产品CID: 1507770
- 产品分类有机原料 → 苯类化合物 → 萘
物理性质
- 熔点220° (some decompn)
- 沸点329.41°C (粗估)
- 闪点87.4ºC
- 密度1.3494 (粗估)
- pKa:5.10±0.58(预测)
- PSA:135.29
- LogP:2
- 折射率1.4455 (估算)
- 外观形态固体-粉末
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用海洋衍生的多氢氧甲丙酮(ECH A),一种海洋衍生物多氢丙烯丙酮,在体外和活体生物活性中表现出多种体外或活性:在细胞培养中,其剂量会独立地增强与老鼠胚胎干细胞的分化(50微米效应,PKC抑制作用IC50~107微M),并将PKCC与KD~6.3微米(NM)捆绑在一起,同时提升米球体质和膜膜潜力. 乙也通过ROS抑制和SRC/LYNP110PI3K/AKT信号促进人体CD34+肝肿瘤前生化器的外活性扩张,抑制了肺炎性宏观活性活性,同时将特雷格的一代引入体外.在动物模型中,静脉ECHA降低小鼠的科炎严重程度和体重量损失,并通过降低凝固降解和发炎来保护UVBN的光成;含有ECH AS2改良生存和减少HSZZZ-S-
MSDS等安全信息
合成工艺路线路线简述
📜2,3-Dichloro-5,8-Dihydroxy-[1,4]Naphthoquinone 在 Manganese(Iv) Oxide,Aluminum Oxide,三氯化铝,硫酸,Cesium Fluoride体系中,用 硝基苯,叔丁醇作为反应溶剂,反应 17.0H,获得 2-Ethyl-3,5,6,7,8-Pentahydroxy-1,4-Naphthoquinone
参考文献:Synthesis Of Some Hydroxynaphthazarins And Their Cardioprotective Effects Under Ischemia-Reperfusion In Vivo
标题:Synthesis Of Some Hydroxynaphthazarins And Their Cardioprotective Effects Under Ischemia-Reperfusion In Vivo
摘要:A Series Of Hydroxynaphthazarins Has Been Synthesized. Some Of Them Were Found In In Vivo Experiments To Be Protectors Of Myocardium Under Ischemia-Reperfusion And To Reduce The Infarction Zone By 50% Without Any Adverse Effect. All Compounds Exhibit A Moderate Or Small Toxicity And Are Active In Low Doses. (C) 1998 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/S0960-894X(98)00075-4
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902600000-乙苯
2907210001-间苯二酚 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Lee SJ, Kim E, Jeong Y, Youm JB, Kim HK, Han J, Vasileva EA, Mishchenko NP, Fedoreyev SA, Stonik VA, Kim SJ, Lee HA. Evaluation of the cardiotoxicity of Echinochrome A using human induced pluripotent stem cell-derived cardiac organoids. Ecotoxicol Environ Saf. 2025 Jan 1;289:117489. doi: 10.1016/j.ecoenv.2024.117489. Epub 2024 Dec 6. 29(1):83-92. doi: 10.4196/kjpp.24.220. Epub 2024 Nov 14.
3: Khalaf ML, Soliman AM, Fahmy SR, Mohamed AS. Anti-thrombotic Mechanisms of Echinochrome A on Arterial Thrombosis in Rats: In-silico, In-vitro and In-vivo Studies. Cardiovasc Hematol Agents Med Chem. 2025;23(2):143-160. doi: 10.2174/0118715257332064241104114546. 12(7):4927-4943. doi: 10.1002/fsn3.4140.
5: Eum DY, Lee C, Tran CS, Lee J, Park SY, Jeong MS, Jin Y, Shim JW, Lee SR, Koh M, Vasileva EA, Mishchenko NP, Park SJ, Choi SH, Choi YJ, Yun H, Heo K. Regulatory role of Echinochrome A in cancer-associated fibroblast-mediated lung cancer cell migration. Toxicol Res. 2024 Apr 11;40(3):409-419. doi: 10.1007/s43188-024-00232-5.
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