CAS: 5096-76-4; 3-Chloro-6-(1H-Pyrrol-1-yl)Pyridazine

该化合物是一种环环状有机化合物,其特征是其和火花糖.在Pyridazine环的三处方位存在氯原子,有助于其反应和各种化学反应的潜在应用.该化合物具有六处方的热质组的特点,可影响其电子特性和生物活动.通常,这种化合物具有有趣的药理特性,因此对药用化学感兴趣.分子结构允许与生物目标进行可能的相互作用,从而可能导致治疗用途.此外,该化合物的溶性,稳定性和再活动性可能因环境条件和其他功能组的存在而不同.与许多外星循环一样,它也可能参与各种合成途径,从而在有机合成中具有价值.由于氯的存在和生物活动的潜力,应当注意安全和处理预防措施.

英文名称3-Chloro-6-(1H-Pyrrol-1-yl)Pyridazine
中文名称3-氯-6-(1H-吡咯-1-基)哒嗪
IUPAC名称3-chloro-6-(1H-pyrrol-1-yl)pyridazine
其它别名3-氯-6-(1H-吡咯-1-基)哒嗪; 3-Chloro-6-Pyrrol-1-Yl-Pyridazine
CAS编号5096-76-4
MFCD编号:MFCD00828665
EINECS号:184-699-9
分子式:C8H6ClN3分子量:179.61
产品CID: 1498244
产品分类有机原料→分子砌块→芳杂环类化合物→吡咯类化合物

相似结构搜索
InChIKey: LQIVORYEWIDSDK-UHFFFAOYSA-N
InChI=1S/C8H6ClN3/c9-7-3-4-8(11-10-7)12-5-1-2-6-12/h1-6H
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数1.0

相似化合物

75792-65-3 85645-18-7 1355236-33-7

MSDS等安全信息

GHS符号GHS07
危险类别急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Warning
危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
危险品标志Xi

欧盟法规

C&L通报

上下游产品

CAS号141-30-0 3,6-二氯哒嗪 | CAS号109-97-7 吡咯 | CAS号696-59-3 2,5-二甲氧基四氢呋喃 | CAS号5469-69-2 3-氨基-6-氯哒嗪

合成工艺路线路线简述

📜3,6-二氯哒嗪,吡咯置于sodium Hydride体系中,用 N,N-二甲基甲酰胺,Mineral Oil 作为反应溶剂,化学反应 0.08H,以83%的收率获得产物3-氯-6-(1H-吡咯-1-基)哒嗪
参考文献:An Electrochemical Nickel-Catalyzed Arylation Of 3-Amino-6-Chloropyridazines
标题:An Electrochemical Nickel-Catalyzed Arylation Of 3-Amino-6-Chloropyridazines
摘要:3-Amino-6-Aryl-And 3-Amino-6-Heteroarylpyridazines Have Been Obtained In Generally Good Yield Using A Nickel-Catalyzed Electrochemical Cross-Coupling Between 3-Amino-6-Chloropyridazines And Aryl Or Heteroaryl Halides At Room Temperature. Comparative Experiments Involving Classical Palladium-Catalyzed Reactions,Such As Suzuki,Stille,Or Negishi Cross-Couplings,Reveal That The Electrochemical Method Can Constitute A Reliable Alternative Tool For Biaryl Formation. A Possible Reaction Mechanism Is Proposed On The Basis Of Electrochemical Analyses.
DOI:10.1021/jo3022428

专利信息

专利号:US-2009118296-A1
优先权日:2005-07-20
标题:Heteroaromatic Compounds As Inhibitors Of Stearoyl-Coenzyme A Delta-9 Desaturase
发明人：BLACK CAMERON; DESCHENES DENIS; GAGNON MARC; LACHANCE NICOLAS; LEBLANC YVES; LEGER SERGE; LI CHUN SING; OBALLA RENATA M
权利人:MERCK FROSST CANADA LTD
摘要:Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; lipid disorders; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and fatty liver disease.