CAS: 487-36-5; 4,4'-((1S,3Ar,4S,6Ar)-Hexahydrofuro[3,4-C]Furan-1,4-Diyl)Bis(2-Methoxyphenol)
该化合物是一种自然产生的离子体,是一种有机化合物,是更大种类的植物化学的一部分,其特征是,其性能性质具有天性,以特定的对应形式存在,有助于其生物活动; (+)-皮诺林的分子公式通常包括碳,氢和氧原子,反映其作为苯酚化合物的结构;该物质以其抗氧化特性而著称,它有助于消除自由基,从而有可能提供健康惠益;它存在于各种植物中,包括某些种子和水果中,并研究其潜在的治疗效果,包括反炎和抗癌活动;此外,(+)-皮诺林在传统医学中可能发挥作用,并且对天然产品化学领域的潜在药物和营养化合物应用感兴趣;其化学物质编号487-36-5,是一个独特的识别资料,有助于科学文献和数据库中对这一化合物进行编目和研究.
- 英文名称4,4'-((1S,3Ar,4S,6Ar)-Hexahydrofuro[3,4-C]Furan-1,4-Diyl)Bis(2-Methoxyphenol)
- 中文名称松脂酚
- IUPAC名称4,4'-((1S,3aR,4S,6aR)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis(2-methoxyphenol)
- 其它别名Phenol,4,4'-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis[2-methoxy-, [1S-(1a,3aa,4a,6aa)]-; Phenol,4,4'-(tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis[2-methoxy-, stereoisomer(8CI); Pinoresinol (6CI,7CI); 1H,3H-Furo[3,4-c]furan, phenol deriv.; (+)-Pinoresinol; d-Pinoresinol
- CAS编号487-36-5
- MFCD编号:MFCD07784516
- FDA UNII编号:V4N1UDY811
- 分子式:C20H22O6分子量:358.39
- 产品CID: 1479048
- 产品分类天然产物 → 木脂素
物理性质
- 熔点121 °C
- 沸点556.5±50.0 °C at 760 mmHg
- 闪点290.4±30.1 °C
- 密度1.3±0.1 g/cm3
- pKa:9.54±0.35(预测)
- PSA:77.38
- LogP:1.54
- 折射率1.598
- 蒸汽压0.0±1.6 mmHg at 25°C
- 溶解性DMSO: ≥6mg/mL
- 外观形态白色至棕褐色固体
- 储存条件密封, 常温干燥保存
- 产品应用该化合物是一种植物衍生的离子南,在毛虫中起到防御化合物的作用;它使癌症细胞对与TNF有关的诱发诱虫性聚氨酯(TRAIL)的诱导性硬化素(TFF)诱导性的硬化剂(TRIL)诱发的硬化酶(ILL)引发的硬质硬化细胞有敏感认识,并且促进诱导死亡的复合信号形成,以触发抗毛虫的抗毛肿细胞中依赖丙酸酶-8的多温性粘合物.
MSDS等安全信息
上下游产品
Diacetate of (+)-epipinoresinol Versicoside pinoresinol (1R,2R,5R,6S)-2-(4-methanesulfonyloxy-3-methoxy)phenyl-6-(4-methanesulfonyloxy-3-methoxy)phenyl-3,7-dioxabicyclo[3.3.0]°Ctane Diacetate of (+)-epipinoresinol (-)-secoisolariciresinol (+)-epipinoresinol dimethyl ether °Ctane2,6-bis-(4-benzyloxy-3-methoxyphenyl)-3,7-dioxabicyclo3.3.0°Ctane合成工艺路线路线简述
- 458-35-5 = 487-36-5 + 85165-02-2
反应条件:1.1 Reagents: β-Cyclodextrin,Oxygen Catalysts: Laccase Solvents: Water; 8 H,Ph 5,30 °C1.2 Reagents: Benzophenone Solvents: Acetonitrile
标题:Controlling The Polymerization Of Coniferyl Alcohol With Cyclodextrins
作者:Tarrago,Lionel; Modolo,Camille; Yemloul,Mehdi; Robert,Viviane; Rousselot-Pailley,Pierre; Et Al
参考文献:New Journal Of Chemistry 日期:2018 卷标:42(14) 页码:11770-11775]
458-35-5 = 487-36-5 + 27003-73-2 + 81446-29-9 + 83327-19-9 + 29388-59-8
反应条件:1.1 Reagents: Nadph,Hydrogen Peroxide Solvents: Water; 1 H,Ph 7,30 °C
标题:Enantioselective Lignan Synthesis By Cell-Free Extracts Of Forsythia Koreana
作者:Umezawa,Toshiaki; Et Al
参考文献:Bioscience 日期:1994 卷标:58(2) 页码:230-4]
32811-40-8 = 487-36-5 + 81446-29-9
反应条件:1.1 Reagents: Oxygen; 2 H,Ph 4.5,45 °C
标题:Laccase Catalyses Phytophenol Furanocyclic Dimerization: Substrate Specificity And Diastereoselective Process
作者:Li,Xican; Et Al
参考文献:Journal Of Molecular Structure 日期:2023 卷标:1274
📜4-羟基-2,6-二(4'-羟基-3'-甲氧基)苯基-3,7-二氧杂二环(3.3.0)辛烷置于diborane-Dimethylsulfoxide体系中,用 四氢呋喃 作为反应溶剂,化学反应 4.0H,以2.5 Mg的收率获得产物松脂酚
参考文献:来自 Lonicera Hypoleuca 的木脂素
标题:来自 Lonicera Hypoleuca 的木脂素
摘要:摘要 一种以 (-)-4-羟基-2,6-二-(4'-羟基-3'-甲氧基)苯基-3,7-二氧杂双环-(3.3.0)辛烷和n-10为特征的新型木脂素-壬烷醇,东莨菪碱,丁香酸,β-谷甾醇及其糖苷,已从忍冬属植物的地上部分分离出来.木脂素的立体化学是通过其光谱分析及其衍生物的光谱分析,以及通过其转化为 (+)-松脂醇而建立的.β-谷甾醇-β-D-葡萄糖苷显示出非常好的解痉活性.
DOI:10.1016/s0031-9422(00)80792-X
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2905399001-1,3-丙二醇
2905399002-1,4-丁二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2014357576-A1
优先权日:2013-05-31
标题:Methods for enhancement of muscle protein synthesis
发明人：BREUILLE DENIS; STELLINGWERFF TRENT; MOORE DANIEL RYAN; OFFORD CAVIN ELIZABETH ANN; PHILLIPS STUART MARTIN
权利人:NESTEC SA
摘要:The present disclosure provides methods for enhancing muscle protein synthesis in an individual in need of same. Specifically, the present disclosure provides methods for enhancing muscle protein synthesis by enhancing myofibrillar muscle protein synthesis. The method includes administering to the individual a mixed macronutrient composition having (i) an amount of whey protein that is not capable of enhancing myofibrillar protein synthesis when ingested by itself and (ii) free leucine. The composition comprises at least about 5.0 g total leucine per dose.
专利号:WO-2015040533-A1
优先权日:2013-09-19
标题:Methods for enhancing muscle protein synthesis during energy deficit
发明人：BAILEY DAVID MARK; ZALTAS ERIC SCOTT; STELLINGWERFF TRENT; MOORE DANIEL RYAN; HAWLEY JOHN ALAN; BURKE LOUISE MARY
权利人:PREMIER NUTRITION CORP
摘要:The present disclosure provides methods for enhancing muscle protein synthesis in an individual in need of same. Specifically, the present disclosure provides methods for enhancing muscle protein synthesis during periods of negative energy balance, or energy deficit. The methods include administering to an individual suffering from energy deficit a composition comprising protein in an amount from about 15 g to about 30 g during a time period selected from the group consisting of during exercise, post-exercise, and combinations thereof. The methods also include administering to an individual suffering from energy deficit a composition comprising protein during a time period selected from the group consisting of during exercise, post-exercise, and combinations thereof, wherein the protein is administered in a dose that is higher than doses typically recommended for individuals experiencing energy balance.
专利号:US-2014294788-A1
优先权日:2013-03-26
标 题 :Methods for enhancing muscle protein synthesis following concurrent training
发明人：BAILEY DAVID MARK; ZALTAS ERIC SCOTT; MOORE DANIEL RYAN; STELLINGWERFF TRENT
权利人:NESTEC SA
摘要:The present disclosure provides methods for enhancing muscle protein synthesis following physical exertion. In a general embodiment, a method for enhancing muscle protein synthesis following physical exertion is provided and includes administering to an individual a composition comprising from about 15 to about 35 g protein immediately following concurrent training. Programs for enhancing muscle adaptation resulting from concurrent training are also provided. The programs include providing a composition comprising from about 15 to about 35 g protein; and providing guidelines for consumption including a recommendation of the amount of the composition to consume immediately following concurrent training.
专利号:US-10392634-B2
优先权日:2016-12-15
标题:Method for high-efficiency production of pinoresinol using an H2O2 auto-scavenging cascade
发明人：ZHOU JINGWEN; CHEN JIAN; LV YONGKUN; DU GUOCHENG
权利人:ZHOU JINGWEN; CHEN JIAN; LV YONGKUN; DU GUOCHENG; UNIV JIANGNAN
摘要:The present invention provides a method for high-efficiency production of pinoresinol by use of an H2O2 auto-scavenging enzymatic cascade. It uses eugenol as the substrate, which is relatively inexpensive and is industrially available. It uses an enzymatic cascade to remove H2O2 produced in the process of pinoresinol synthesis, thereby reducing its inhibitory effect on the enzyme activity. In addition, the present invention uses whole cells as a catalyst, which can continuously regenerate cofactors needed by the enzyme, thus eliminating the need for exogenous addition of expensive cofactors during the reaction. The yield of the present invention can reach 7.12 g/L and the conversion rate is 61.55%.
专利号:US-2018105546-A1
优先权日:2011-06-14
标题:Methods for Chemical Synthesis of Biologically Active Compounds Using Supramolecular Protective Groups and Novel Compounds Obtainable Thereby
专利号:CN-106148355-A
优先权日:2016-06-30
标 题:Application of the IiAP2/ERF049 gene in Isatis indigo in regulating the synthesis of lignans
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1. López-Biedma, A., Sánchez-Quesada, C., Delgado-Rodríguez, M., et al. The biological activities of natural lignans from olives and virgin olive oils: A review. J. Funct. Foods 26, 36-47 (2016). 2. Li, D.-Q., Wang, D., Zhou, L., et al. Antioxidant and cytotoxic lignans from the roots of Bupleurum chinense. J. Asian Nat. Prod. Res. 19(5), 519-527 (2017). 3. Wikul, A., Damsud, T., Kataoka, K., et al. (+)-Pinoresinol is a putative hypoglycemic agent in defatted sesame (Sesamum indicum) seeds though inhibiting α-glucosidase. Bioorg. Med. Chem. Lett. 22(16), 5215-5217 (2012). 4. In, S.-J., Seo, K.-H., Song, N.-Y., et al. Lignans and neolignans from the stems of Vibrunum erosum and their neuroprotective and anti-inflammatory activity. Arch. Pharm. Res. 38(1), 26-34 (2015).合成参考文献
摘要:Herter, S.; Turner, N. J., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 3, 67.
参考文献:10.1023/a:1026437406859
摘要:LaFayette PR, Eriksson KE, Dean JF. Characterization and heterologous expression of laccase cDNAs from xylem tissues of yellow-poplar (Liriodendron tulipifera). Plant Mol Biol. 1999 May;40(1):23–35. doi: 10.1023/a:1026437406859.
参考文献:10.1073/pnas.0603865103
摘要:Ono E, Nakai M, Fukui Y, Tomimori N, Fukuchi-Mizutani M, Saito M, Satake H, Tanaka T, Katsuta M, Umezawa T, Tanaka Y. Formation of two methylenedioxy bridges by a Sesamum CYP81Q protein yielding a furofuran lignan, (+)-sesamin. Proc. Natl. Acad. Sci. U.S.A. 2006 Jun 27;103(26):10116–21. doi: 10.1073/pnas.0603865103.
参考文献:10.1186/1471-2164-15-388
摘要:Li Q, Chen J, Xiao Y, Di P, Zhang L, Chen W. The dirigent multigene family in Isatis indigotica: gene discovery and differential transcript abundance. BMC Genomics. 2014 May 20;15():388.
参考文献:10.1371/journal.pone.0171390
摘要:Zhu Y, Kawaguchi K, Kiyama R. Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors. PLoS ONE. 2017 Feb 02;12(2):e0171390. doi: 10.1371/journal.pone.0171390.
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