CAS: 407-25-0; Trifluoroacetic Anhydride

上下游产品

CAS号421-59-0 diiodo(trifluor... | CAS号2966-50-9 三氟乙酸银 | CAS号407-38-5 三氟乙酸2,2,2-三氟乙酯 | CAS号76-05-1 三氟乙酸(TFA) | CAS号86024-51-3 (pentafluoro-l6... | CAS号50-56-6 催产素 | CAS号383-63-1 三氟乙酸乙酯 | CAS号7727-37-9 氮气 | CAS号111185-41-2 1H-Pyrrole, 2,5... | CAS号109317-78-4 4-丁氧基-1,1,1-三氟-... | CAS号10056-69-6 2,2,2-trifluoro... | CAS号106324-53-2 6-methyl-2-(tri... | CAS号109613-00-5 4-乙酰苯基三氟甲烷磺酸酯 | CAS号105189-44-4 3,5-二溴酪氨酸三氟乙酰胺甲酯 | CAS号109317-74-0 2,3-二氢-5-三氟乙酰基吡喃 | CAS号111217-41-5 2,2,2-trifluoro... | CAS号107940-04-5 (2-methoxy-2-ox... | CAS号106823-31-8 N-[2-(5,6-diphe...

三氟乙酸置于phosphorus Pentoxide体系中,化学反应生成 三氟乙酸酐
参考文献:2,2,2-三氟乙基芳基硒化物:Arsech 2 Cf 3(ar = C 6 H 5,P-Ch 3 C 6 H 4)及其衍生物arse(o)ch 2 Cf 3和arse(x)2 Ch 2 Cf 3(x = Cl,Br,Ooccf 3)
标题:2,2,2-三氟乙基芳基硒化物:Arsech 2 Cf 3(ar = C 6 H 5,P-Ch 3 C 6 H 4)及其衍生物arse(o)ch 2 Cf 3和arse(x)2 Ch 2 Cf 3(x = Cl,Br,Ooccf 3)
摘要:通过使合适的亚硒酸芳基酯阴离子与2,2,2-三氟乙基甲苯磺酸酯在回流的四氢呋喃中反应,以高收率制备标题硒化物.这些不对称的二价硒化物可以与元素氯和溴氧化为相应的四价硒化合物arse(x)2 Ch 2 Cf 3(x = Cl和br).后者在碱性水解后得到亚硒酸盐arse(o)chcf 3.硒化物还通过硒化物与过氧化氢的直接反应形成.与三氟乙酸酐反应后,得到三氟乙酸酯衍生物arse(ooccf 3)2 Ch 2 Cf 3,以定量得出.通过元素分析,红外光谱,1 H和19 F NMR光谱以及质谱对化合物进行了表征.
DOI:10.1016/0022-1139(93)02933-6

专利信息

专利号:US-10954178-B1
优先权日:2020-08-28
标题 :Synthesis of haloindenes
发明人：WNUK STANISLAW F; HOWLADER MD ABU HASAN
权利人:WNUK STANISLAW F; HOWLADER MD ABU HASAN; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:The subject invention provides an expedited synthesis of 5, 6, and 7-iodoindenes from the corresponding aminoindan-1-ones in more than 70% yield, employing readily available precursors and reagents. A three-step sequence involves diazotization-iodination of aminoindan-1-one followed by reduction and dehydration. The method has a general character and can be extended for the preparation of various 4-, 5-, 6- or 7-haloindenes using different halogen sources for diazotization-halogenation reaction.

专利号:US-2012190064-A1
优先权日:2004-10-01
标题 :Feeding buffers, systems, and methods for in vitro synthesis of biomolecules
发明人：KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA
权利人:KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA; LIFE TECHNOLOGIES CORP
摘要:Compositions, methods and kits for in vitro systems for synthesis of biomolecules such as polypeptides, are provided herein. Cell extracts that provide enhanced yields of soluble proteins using in vitro protein synthesis methods are provided. The invention also includes methods for producing high yields of proteins by the addition of a feeding solution that includes amino acids and an energy source to an ongoing in vitro synthesis system. The invention also includes methods of using a high-yield in vitro synthesis system to produce large quantities of proteins with incorporated labeled amino acids for analysis by methods such as by NMR. The invention further includes vectors for enhanced production of proteins from nucleic acid templates using in vitro synthesis systems.

专利号:US-7420052-B2
优先权日:2001-08-24
标 题:Intermediates for synthesis of vinblastine, process for preparation of the intermediates and process for synthesis of vinblastines
发明人：FUKUYAMA TOHRU; TOKUYAMA HIDETOSHI; YOKOSHIMA SATOSHI
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:An intermediate for vinblastine synthesis represented by general formula A. n ngeneral formula A.n n(in the formula, R 1 , R 2 , R 3 and R 4 are the group selected independently from the group consisting of H, lower alkyl group, lower alkoxy group, halogen, lower perfluoroalkyl group, lower alkylthio group, hydroxy group, amino group, mono- or di-alkyl or acylamino group, lower alkyl or arylsulfonyloxy group. R 5 is H, or a lower alkyl group or a substituted or non-substituted aryl group, R 6 is an alkyl group of carbon number 4 or less, R 7 is a substituted or non-substituted aryl group, R 8 is a substituted or non-substituted aryl group or lower alkyl group and R 9 is an acyl group or trialkylsilyl group.) A method for synthesis of the compound of general formula A utilizing radical ring forming reaction of thioanilides and using the compound of general formula B as the starting material, synthesizing thioanilide of general formula C by the reaction with compound 1 and the formation of a 11-membered ring by intramolecular alkylation of 2-nitrobenzenesulfonamide by which the reactions can proceed under mild conditions and high yield can be accomplished.

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-9193691-B2
优先权日:2012-04-27
标题:Methods for the synthesis of activated ethylfumarates and their use as intermediates
发明人：KRAFT KELLY SULLIVAN; FREEMAN JOHN J; SERWINSKI PAUL; PAVIA VINNIE; PHANSTIEL OTTO; KAUR NAVNEET
权利人:MANNKIND CORP; MANNKIND CORP
摘要:Disclosed embodiments relate to improved methods for the synthesis of activated fumarate intermediates and their use in chemical synthesis. Disclosed embodiments describe the synthesis of activated fumarate esters including those derived from activating groups including: 4-nitrophenyl, diphenylphosphoryl azide, pivaloyl chloride, chlorosulfonyl isocyanate, p-nitrophenol, MEF, trifluoroacetyl and chlorine, for example, ethyl fumaroyl chloride and the subsequent use of the activated ester in situ. Further embodiments describe the improved synthesis of substituted aminoalkyl-diketopiperazines from unisolated and unpurified intermediates allowing for improved yields and reactor throughput.

专利号:WO-2021108999-A1
优先权日:2019-12-03
标 题 :Method for continuous synthesis of 4-ethoxy-1,1,1-trifluoro-3-buten-2-one
发明人：HONG HAO; ZHANG ENXUAN; LU JIANGPING; SHEN WEI; YAN HONGLEI; LIU YUNPENG
权利人:LIAONING ASYMCHEM LABORATORIES CO LTD
摘要:Disclosed is a method for the continuous synthesis of 4-ethoxy-1,1,1-trifluoro-3-buten-2-one. The continuous synthesis method comprises: continuously introducing a raw material comprising vinyl ethyl ether, triethylamine and trifluoroacetic anhydride into a continuous reactor for a reaction to obtain a product system containing 4-ethoxy-1,1,1-trifluoro-3-buten-2-one, and continuously extracting the product system to obtain 4-ethoxy-1,1,1-trifluoro-3-buten-2-one. By using the continuous process, the above-mentioned raw materials can all be conveniently and accurately introduced into the continuous reactor, and after the reaction is completed, continuous extraction is also used for a post-treatment. The whole process is rapid, simple and efficient, the efficiency of the whole synthesis process is greatly increased, product destruction loss is reduced, and hidden safety hazards during batch production are avoided. After scaling up, there is no amplification effect, and safety and a relatively high synthesis efficiency can still be maintained.