CAS: 36724-68-2; (S)-1-(2,2,2-Trifluoroacetyl)Pyrrolidine-2-Carbonyl Chloride

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CAS号147-85-3 脯氨酸 | CAS号97522-31-1 (2S)-2-Benzylpy...

📜(S)-1-(Trifluoroacetyl)Pyrrolidine-2-Carboxylic Acid置于草酰氯,N,N-二甲基甲酰胺体系中,用 二氯甲烷 用作溶剂,化学反应 3.0H,反应生成(S)-(-)-N-(三氟乙酰基)吡咯烷-2-羰酰氯
参考文献:分子内催化生成的金属类胡萝卜素反应生成的铵化铵的重排.第2部分.双环胺的立体选择性合成
标题:分子内催化生成的金属类胡萝卜素反应生成的铵化铵的重排.第2部分.双环胺的立体选择性合成
摘要:由束缚在环状烯丙基胺上的铜类胡萝卜素的分子内反应产生的铵化铵经过[2,3]重排以传递双环胺.该反应可以使用其中重氮基团与氮相邻地连接的环状n-烯丙胺或其中重氮基团为n的乙烯基取代的环状胺来进行.-拴在戒指上.在前一类反应中,立体选择性叶立德的形成和重排通常可实现高水平的非对映控制.在后一种情况下,当使用对映体纯的底物进行反应时,可以实现有效的"手性转移".该反应已用于构建吡咯烷,吲哚并咪唑和喹唑烷系统,并在甘露糖胺和兽用生物碱中发现了ce亚基.
Doi:10.1039/b108182A

专利信息

专利号:US-4000197-A
优先权日:1973-07-23
标 题 :Asymmetric synthesis of phenylisopropylamines
发明人：BARFKNECHT CHARLES F; NICHOLS DAVID E
权利人:UNIV IOWA RES FOUND
摘要:The synthesis of enantiomers of a series of methoxy- and alkyl- substituted phenylisopropylamines is described. The synthesis comprises reducing the imines, formed by the reaction of appropriate phenylacetones with either (+)- or (-)-α-methylbenzylamine, by low-pressure reduction techniques, and subsequently subjecting the optically active N-(α-phenethyl)phenylisopropylamine derivative to hydrogenolysis. The hydrogenolysis products are characterized by enantiomeric purities in the range of 96 - 99%. Yields of products are approximately 60%.

专利号:US-5468876-A
优先权日:1986-05-22
标题:Intermediates for the stereoconservative synthesis of 1-substituted (S)-and (R)-2-aminomethylpyrrolidines
发明人：FEDERSEL HANS-JUEGEN; HOE THOMAS; RAEMSBY STEN I; STROEM PETER H E
权利人:ASTRA AB
摘要:Disclosed are (R)- and (S)-isomers of the compounds of the Formulas II and III with at least 95% optical purity ##STR1## wherein R 1 and R 2 are the same or different and represent a hydrogen atom, a lower alkyl, lower alkenyl or lower alkynyl group, a cycloalkyl group or a group (CH 2 ) m Ph, wherein m is 0-3 and Ph is a substituted or unsubstituted phenyl group. n These compounds are intermediates in the stereoconservative synthesis of 1-substituted (S)- and (R)-2-aminomethylpyrrolidines.

专利号:US-3943142-A
优先权日:1969-01-24
标 题:Dye intermediates and their preparation and use in the synthesis of methine dyes
发明人：OWEN JOHN R
权利人:EASTMAN KODAK CO
摘要:Compositions of matter are provided comprising a stable, non-vaporous monomeric methylene base selected from a 2-methylenethiazoline; a 2-methylenebenzothiazoline; a 2-methylenenaphthothiazoline; a 2-methylenebenzoselenazoline; and a 2-methylenenaphthoselenazoline. The compositions of the invention are prepared by reacting the parent 2-methyl quaternary salt with a non-hydroxylic base which removes a proton of the heterocyclic salt together with a proton acceptor which inhibits build-up of the hydro salt of the non-hydroxylic base, the reaction being conducted under anhydrous conditions in a non-hydroxylic liquid in which the heterocyclic quaternary salt is sufficiently insoluble to inhibit dimer formation. The compositions of the invention are employed in the preparation of methine dyes.

专利号:WO-8707271-A1
优先权日:1986-05-22
标 题 :A stereoconservative synthesis of 1-substituted (s)- and (r)-2-aminomethylpyrrolidines and intermediates thereto

专利号:US-5300660-A
优先权日:1986-05-22
标 题:Efficient stereoconservative synthesis of 1-substituted (S)- and (R)-2-aminomethylpyrrolidines and intermediates thereto

专利号:EP-0270596-A1
优先权日:1986-05-22
标题 :A stereoconservative synthesis of 1-substituted (s)- and (r)-2-aminomethylpyrrolidines and intermediates thereto