📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于过氧化氢苯甲酰,乙醚体系中,化学反应生成α-D-(+)-塔罗糖 参考文献:Pigman; Isbell,Journal Of Research Of The National Bureau Of Standards (United States),1937,Vol. 19,P. 189,210 标题:Pigman; Isbell,Journal Of Research Of The National Bureau Of Standards (United States),1937,Vol. 19,P. 189,210
专利号:US-7344863-B2 优先权日:1998-03-13 标题:Methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules 发明人:LI WU-BO; JESSEE JOEL A; SCHUSTER DAVID; XIA JIULIN; GEBEYEHU GULILAT 权利人:INVITROGEN CORP 摘要:The present invention is directed to compositions and methods for enhancing synthesis of nucleic acid molecules, particularly GC-rich nucleic acid molecules. Specifically, the invention provides compositions comprising one or more nitrogen-containing organic compounds having a formula selected from the group consisting of formula I and formula II (or salts or derivatives thereof), preferably 4-methylmorpholine N-oxide or betaine (carboxymethyltrimethylammonium), and further comprising one or more compounds selected from the group consisting of proline and an N-alkylimidazole compound, and more preferably proline, 1-methylimidazole or 4-methylimidazole. The invention further relates to methods for enhanced, high-fidelity synthesis of nucleic acid molecules, including via amplification (particularly PCR), reverse transcription, and sequencing methods. The invention also relates to nucleic acid molecules synthesized by these methods, to fragments or derivatives thereof, and to vectors and host cells comprising such nucleic acid molecules, fragments, or derivatives. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the compositions of the invention.
专利号:US-7429658-B2 优先权日:2003-09-11 标题 :Synthesis of protected pyrrolobenzodiazepines 发明人:HOWARD PHILIP; MASTERSON LUKE 权利人:SPIROGEN LTD 摘要:A method of synthesis of a N-10 protected PBD compound of formula (I): n nvia an intermediate of formula (II) or formula (V):
专利号:US-10973847-B2 优先权日:2017-06-30 标题 :Core-to-surface polymerization for the synthesis of star polymers and uses thereof 发明人:JOHNSON JEREMIAH A; GOLDER MATTHEW R 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:Disclosed are methods, compositions, reagents, systems, and kits to prepare star polymers, as well as compositions and uses thereof. Various embodiments show that synthesis of these polymers contain low metal concentration to provide polymers for diverse biomedical applications including in vivo applications.
专利号:US-7557099-B2 优先权日:2004-03-01 标题 :Pyrrolobenzodiazepines as key intermediates in the synthesis of dimeric cytotoxic pyrrolobenzodiazepines 发明人:HOWARD PHILIP WILSON; KANG GYOUNG-DONG 权利人:SPIROGEN LTD 摘要:Compounds and a method of synthesis of compounds of formula (Ia) or (Ib): and salts, solvates, and chemically protected forms thereof, wherein the dotted lines indicate the optional presence of a double bond between C1 and C2 or C2 and C3; R 2 and R 3 are independently selected from —H, â•?O, â•?CH 2 , —CN, —R, OR, halo, â•?CH—R, O—SO 2 —R, CO 2 R and COR; R 10 is a carbamate-based nitrogen protecting group; and R 11 is an oxygen protecting group.
专利号:US-8183355-B2 优先权日:2006-04-28 标题 :Method for the synthesis of oligonucleotide derivatives 发明人:MORVAN FRANCOIS; MEYER ALBERT; VASSEUR JEAN-JACQUES; VIDAL SEBASTIEN; CLOAREC JEAN-PIERRE; CHEVOLOT YANN; SOUTEYRAND ELIANE 权利人:MORVAN FRANCOIS; MEYER ALBERT; VASSEUR JEAN-JACQUES; VIDAL SEBASTIEN; CLOAREC JEAN-PIERRE; CHEVOLOT YANN; SOUTEYRAND ELIANE; CENTRE NAT RECH SCIENT 摘要:Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a “click chemistryâ€? reaction between an azide function on the molecule of interest and an alkyne function on the oligonucleotide, or between an alkyne function on the molecule of interest and an azide function on the oligonucleotide. n Intermediate molecules, notably alkyne functionalized oligonucleotides, grafted oligonucleotides, azide functionalized oligonucleotides, oligonucleotide micro arrays containing them and the use of those grafted oligonucleotides for biological investigation and for cell targeting.
专利号:US-9006425-B2 优先权日:2009-03-18 标题:Aluminum complexes and their use in the synthesis of cyclic carbonates 发明人:NORTH MICHAEL 权利人:NORTH MICHAEL; UNIV YORK 摘要:Dimeric aluminum catalysts of formula I: and their use in catalyzing the synthesis of cyclic carbonates from epoxides and carbon dioxide.
[参考文献]: Broder Rühmann, Et Al. Fast Carbohydrate Analysis Via Liquid Chromatography Coupled With Ultra Violet And Electrospray Ionization Ion Trap Detection In 96-Well Format. J Chromatogr A. 2014 Jul 11:1350:44-50. [参考文献]: Tao Wu, Et Al. Application Of Metabolomics In Traditional Chinese Medicine Differentiation Of Deficiency And Excess Syndromes In Patients With Diabetes Mellitus. Evid Based Complement Alternat Med. 2012:2012:968083. [参考文献]: Xiu-Zhen Shi, Et Al. Functions Of Armigeres Subalbatus C-Type Lectins In Innate Immunity. Insect Biochem Mol Biol. 2014 Sep:52:102-14. [参考文献]: Yasuhiko Matsumoto, Et Al. An Invertebrate Hyperglycemic Model For The Identification Of Anti-Diabetic Drugs. Plos One. 2011 Mar 30;6(3):E18292.
合成参考文献
参考文献:10.1111/j.1742-4658.2011.08414.x 摘要:Masuyer G, Jabeen T, Öberg CT, Leffler H, Nilsson UJ, Acharya KR. Inhibition mechanism of human galectin‐7 by a novel galactose‐benzylphosphate inhibitor. The FEBS Journal. 2011 Nov 30;279(2):193–202. doi: 10.1111/j.1742-4658.2011.08414.x.