专利号:US-11407993-B2 优先权日:2017-02-14 标 题 :Method for the synthesis of DNA conjugates by micellar catalysis 发明人:BHAT AVINASH SHASHIDHAR; KLIKA SKOPIC MATEJA; BRUNSCHWEIGER ANDREAS; WEBERSKIRCH RALF 权利人:UNIV DORTMUND TECH 摘要:A method for the synthesis of a chimeric conjugate molecule by micellar catalysis that may form part of DNA-encoded compound libraries. A DNA-coupled organic starter molecule may be reacted with another organic compound, using a catalyst located within a micelle, to form a conjugate of an organic candidate compound coupled to a DNA identifier tag.
专利号:WO-0125179-A1 优先权日:1999-10-01 标 题:Preparation of tetracyclic intermediates 发明人:CHEN QING PING; WOODS ROSS ALEXANDER; ELLIOTT ROBYN LOUISE 权利人:INST OF DRUG TECHNOLOGY AUSTRA; CHEN QING PING; WOODS ROSS ALEXANDER; ELLIOTT ROBYN LOUISE 摘要:The invention provides a process for preparing deoxytetracyclic compounds of formula (I) useful in the synthesis of anthracyclines by the rearrangement of thiono ester derivatives followed by reduction, as well as intermediates useful therefor. In said formula, R is H or optionally protected OH.
专利号:US-6303717-B1 优先权日:1997-02-05 标 题:Metal catalyzed synthesis of hyperbranched ethylene and/or α-olefin polymers 发明人:SEN AYUSMAN; KIM JANG SUB; PAWLOW JAMES H; MURTUZA SHAHID; KACKER SMITA; WOJCINSKI III LOUIS M 权利人:UNIV PENN STATE RES FOUND 摘要:Oily hyperbranched polymers derived from ethylene, propylene, butene and/or a C 5 -C 24 α-olefin, and a method for their synthesis, are disclosed. The polymers have non-regular microstructures and are characterized by a ratio ()of methyl hydrogens centered around 0.85 ppm on the 1H-NMR spectra of the polymers relative to total aliphatic hydrogens of from about 0.40 to about 0.65 for polymers derived from ethylene or butene, and a ratio ()of from greater than 0.50 to about 0.65 for polymers derived from propylene. A method for grafting hyperbranched polymers derived from ethylene, propylene, butene and/or a C 5 -C 24 α-olefin onto aromatic rings in organic molecules and polymers, and the resulting grafted materials, are also disclosed. The hyperbranched polymers and grafted materials are useful, for example, as lubricants and lubricant additives.
专利号:WO-2013076053-A1 优先权日:2011-11-25 标题:Synthesis of polyalkylene polyamines with low color index by homogeneously catalyzed alcohol amination in the presence of hydrogen 发明人:STRAUTMANN JULIA; SCHAUB THOMAS; HUEFFER STEPHAN; MAAS STEFFEN; PACIELLO ROCCO 权利人:BASF SE; STRAUTMANN JULIA; SCHAUB THOMAS; HUEFFER STEPHAN; MAAS STEFFEN; PACIELLO ROCCO 摘要:The invention relates to a method for the production of polyalkylene polyamines by homogeneously catalyzed alcohol amination, wherein aliphatic alkanolamines are reacted with each other or aliphatic diamines or polyamines are reacted with aliphatic diols or polyols in the presence of a homogeneous catalyst while eliminating water and in the presence of hydrogen gas. The invention further relates to polyalkylene polyamines, which can be obtained by said methods, and to polyalkylene polyamines which contain hydroxyl groups, secondary amines or tertiary amines. The invention finally relates to uses of said polyalkylene polyamines as adhesion promoters in inks, adhesion promoters in composite films, cohesion promoters in adhesives, cross-linkers/hardeners for resins, primers for paints, wet adhesion promoters for dispersion paints, complexing agents and flocculants, penetration auxiliaries for use in wood preservation, corrosion inhibitors, and immobilization agents of proteins and enzymes.
专利号:US-11518726-B2 优先权日:2017-10-11 标题 :Synthesis of bicyclo[2.2.2]octane derivatives 发明人:HU YUE RACHEL; HEMBRE ROBERT THOMAS; TUSTIN GERALD CHARLES; LIU ZHUFANG; ADAMS STEVEN J 权利人:EASTMAN CHEM CO 摘要:Provided is a process for the preparation of certain 1,4-bicyclo[2.2.2]octane derivatives. The new synthetic procedure involves treating 1,4-dimethylene cyclohexane with an oxidizing agent in the presence of a transition metal catalyst to afford an oxo-substituted bicyclo[2.2.2]octane species. This intermediate structure can then be further derivatized. The processes of this disclosure thus affords a novel and simplified means for the commercial production of a wide variety of bicyclo[2.2.2]octane derivatives.
专利号:US-4594463-A 优先权日:1985-01-28 标 题:Synthesis of aldehydes from alcohols 发明人:WEGMAN RICHARD W; MILLER DEBORAH S 权利人:UNION CARBIDE CORP 摘要:A catalyst has been found for the low pressure hydroformylation of alcohols to produce aldehydes. This catalyst consists of a rhodium containing compound, an iodide containing compound, and a chelating Group V compound, which is used alone or in combination with a monodentate, Group V compound. n It is the first rhodium-based catalyst that generates acetaldehyde via hydroformylation of the methanol. The reaction is typically carried out at 160°-180° C. and 1000-2000 psi. The acetaldehyde rate and selectivity are 1-5 Mhr -1 and 50-75%. Conventional cobalt catalysts require operating pressures of at least 3000-6000 psi in order to obtain reasonable productivities.
参考标题: Methods, Processes And Intermediates For Preparing Chroman Compounds Procédés, Processus Et Intermédiaires Pour La Préparation De Composés Chromane 摘要:This Disclosure Describes An Economical And Scalable Method And Process To Synthesize The Calcium Sensing Receptor (Casr) Modulating Agent 2-Methyl-5-((2R,4S)-2-((((R)-1-(Naphthalen-1-Yl)Ethyl)Amino)Methyl)Chroman-4-Yl)Benzoic Acid, Its Intermediates And Pharmaceutically Acceptable Salts Therefor. Uses Of Said Intermediates For Synthesis Of Compounds Which May Be Intermediates To The Synthesis Of 2-Methyl-5-((2R,4S)-2-((((R)-1-(Naphthalen-1-Yl)Ethyl)Amino)Methyl)Chroman-4-Yl)Benzoic Acid Are Also Described Herein.
合成参考文献
摘要:O'Connor, J. M., Science of Synthesis, (2001) 1, 696. 摘要:Ito, T.; Minato, M., Science of Synthesis, (2003) 2, 358.