专利号:US-6075166-A 优先权日:1995-03-31 标题 :Photolytically cleavable encoding and linking agents for use in combinatorial chemistry 发明人:GARIGIPATI RAVI SHUNKER; ADAMS JERRY LEROY 权利人:SMITHKLINE BEECHAM CORP 摘要:The present invention is to novel photochemically cleavable aryl sulfonamides of the formula n n P--A.sub.3 --A.sub.2 --A.sub.1 --S(O).sub.2 NR.sub.1 R.sub.2 n n wherein n R 1 and R 2 are independently selected from optionally substituted alkyl, arylalkyl or heteroarylalkyl; n A 1 is an aryl or heteroaryl moiety; n A 2 is a linking agent is an aryl, heteroaryl, arylalkyl, heteroaryl alkyl, or an alkyl, wherein the alkyl moiety in the arylalkyl, heteroaryl alkyl, or alkyl group is optionally interrupted one or more times independently by oxygen, NR 3 , sulfur or an amide group; n R 3 is alkyl; n A 3 is an electron rich aryl or heteroaryl moiety having an E 1/2 potential of 0.5 to 2.0 and which moiety is capable of forming an exciplex; n P is a solid support. n Another aspect of the present invention is to the novel use of these photolytically cleavable aryl sulfonamides in combinatorial chemistry synthesis, for use in non-sequential encoding, as a tagging agent. n Another aspect of the present invention is to the novel use of these photolytically cleavable aryl sulfonamides in combinatorial chemistry synthesis, as a linking agent which is bound to a solid support, and upon photolytic cleavage will provide a free amine of the desired final products, i.e. the use of sulfonamides for the solid phase synthesis of amines.
专利号:US-5783699-A 优先权日:1986-10-22 标 题:Chemiluminescent acridinium salts 发明人:MATTINGLY PHILLIP GREGORY; BENNETT LARRY GENE 权利人:ABBOTT LAB 摘要:Acridinium sulfonylamides and isomers, such as phenanthridinium sulfonylamides, may be employed in applications including chemiluminmescent immunoassays. Methods for synthesis of these compounds include contacting an amine with a sulfonylhalide to form a sulfonamide and acylating with an activated carboxylic acid of an acridine or isomer thereof. The N-sulfonyl-9-acridinium carboxamide and isomers may be conjugated to antigens, haptens, antibodies, and nucleic acids for use in chemiluminescent assays.
参考标题:Sulfonyl Azides As Precursors In Ligand-Free Palladium-Catalyzed Synthesis Of Sulfonyl Carbamates And Sulfonyl Ureas And Synthesis Of Sulfonamides 作者:Shiao Y. Chow,Marc Y. Stevens,Luke R. Odell |发布日期:2016.4.1 摘要:An Efficient Synthesis Of Sulfonyl Carbamates And Sulfonyl Ureas From Sulfonyl Azides Employing A Palladium-Catalyzed Carbonylation Protocol Has Been Developed. Using A Two-Chamber System, Sulfonyl Azides, Pdcl2, And Co Gas, Released Ex Situ From Mo(Co)6, Were Assembled To Generate Sulfonyl Isocyanates In Situ, And Alcohols And Aryl Amines Were Exploited As Nucleophiles To Afford A Broad Range Of Sulfonyl