CAS: 1979-96-0; 4,6-Dichloro-2-(Methylthio)-5-Nitropyrimidine

该化合物是一种七环有机化合物,其特征是其火利米丁环,在4和6个位置上以氯原子替代,在2个位置上以甲基硫磷为组,在5个位置上以硝基化合物为组;该化合物通常是在室内温度下的固体,表现出黄色至褐色的青色;已知其在制药和农用化学品中的潜在用途,特别是作为各种生物活性化合物合成的中间体;氯和硝基化合物的存在有助于其再活性,使其有助于进一步的化学转化;此外,甲基硫磷组可影响该化合物的溶性和生物活动;与许多卤化化合物一样,必须处理4,6-二氯-2-(甲基硫基)-5-硝基罗米丁,同时顾及潜在的毒性和环境关切.在实验室或工业环境中与该物质打交道时,应注意适当的安全措施.

结构式图片

相似化合物

333388-03-7 145783-14-8 4316-93-2

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

CAS号1979-97-1 2-(甲巯基)-5-硝基嘧啶-... | CAS号1979-98-2 2-甲硫基-4,6-二羟基嘧啶 | CAS号38136-96-8 6-氯-2-(甲巯基)-5-硝...

合成工艺路线路线简述

    📜4-Chloro-2-Methylsulfanyl-5-Nitro-1H-Pyrimidin-6-One置于盐酸,三乙胺,三氯氧磷体系中,化学反应生成2-甲硫基-4,6-二氯-5-硝基嘧啶
    参考文献:Discovery Of 5-Nitro-6-Thiocyanatopyrimidines As Inhibitors Of Cryptococcus Neoformans And Cryptococcus Gattii
    标题:Discovery Of 5-Nitro-6-Thiocyanatopyrimidines As Inhibitors Of Cryptococcus Neoformans And Cryptococcus Gattii
    摘要:
    Doi:10.1021/acsmedchemlett.1C00038

    海关参考信息

    专利信息


    专利号:US-7105666-B2
    优先权日:2002-06-27
    标 题:Synthesis of purine derivatives
    发明人：HAMMARSTROEM LARS G J; KRAUSS NANCY ELISABTH; LABADIE SHARADA SHENVI; SMITH DAVID BERNARD; TALAMAS FRANCISCO XAVIER
    权利人:ROCHE PALO ALTO LLC
    摘要:The present invention provides a method for producing 2-, 6-, 8- and 9-substituted purine compounds from 4,6-dihalo-5-nitro-2-alkyl-pyrimidine compounds in solution or by solid phase techniques. The present process provides for the sequential introduction of amine substituents at the 4- and 6-positions, displacement of an alkylsulfony group at the 2-position of the pyrimidine, reduction of the nitro group and formation of the imidazole portion of the purine compound. Furthermore, the methods of the present invention are ideally suited to the preparation of a library of purine compounds.

    专利号:JP-2005535631-A
    优先权日:2002-06-27
    标题 :Synthesis of purine derivatives

    专利号:US-2004034224-A1
    优先权日:2002-06-27
    标题:Synthesis of purine derivatives

    专利号:EP-1519938-A2
    优先权日:2002-06-27
    标题:Synthesis of purine derivatives

    专利号:WO-2004002990-A2
    优先权日:2002-06-27
    标题 :Synthesis of purine derivatives

    专利号:DE-60313173-T2
    优先权日:2002-06-27
    标 题:SYNTHESIS OF PURIN DERIVATIVES

    其他信息查阅

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    实用工具

    ⚠️全国化工行业净网倡议书
    📋制造商识别码
    📖 海关编码查询
    📝MSDS生成器

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 408.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知