CAS: 1979-96-0; 4,6-Dichloro-2-(Methylthio)-5-Nitropyrimidine

相似化合物

333388-03-7 145783-14-8 4316-93-2

上下游产品

CAS号1979-97-1 2-(甲巯基)-5-硝基嘧啶-... | CAS号1979-98-2 2-甲硫基-4,6-二羟基嘧啶 | CAS号38136-96-8 6-氯-2-(甲巯基)-5-硝...

4-Chloro-2-Methylsulfanyl-5-Nitro-1H-Pyrimidin-6-One置于盐酸,三乙胺,三氯氧磷体系中,化学反应生成2-甲硫基-4,6-二氯-5-硝基嘧啶
参考文献:Discovery Of 5-Nitro-6-Thiocyanatopyrimidines As Inhibitors Of Cryptococcus Neoformans And Cryptococcus Gattii
标题:Discovery Of 5-Nitro-6-Thiocyanatopyrimidines As Inhibitors Of Cryptococcus Neoformans And Cryptococcus Gattii
摘要:
Doi:10.1021/acsmedchemlett.1C00038

专利信息

专利号:US-7105666-B2
优先权日:2002-06-27
标 题:Synthesis of purine derivatives
发明人：HAMMARSTROEM LARS G J; KRAUSS NANCY ELISABTH; LABADIE SHARADA SHENVI; SMITH DAVID BERNARD; TALAMAS FRANCISCO XAVIER
权利人:ROCHE PALO ALTO LLC
摘要:The present invention provides a method for producing 2-, 6-, 8- and 9-substituted purine compounds from 4,6-dihalo-5-nitro-2-alkyl-pyrimidine compounds in solution or by solid phase techniques. The present process provides for the sequential introduction of amine substituents at the 4- and 6-positions, displacement of an alkylsulfony group at the 2-position of the pyrimidine, reduction of the nitro group and formation of the imidazole portion of the purine compound. Furthermore, the methods of the present invention are ideally suited to the preparation of a library of purine compounds.

专利号:JP-2005535631-A
优先权日:2002-06-27
标题 :Synthesis of purine derivatives

专利号:US-2004034224-A1
优先权日:2002-06-27
标题:Synthesis of purine derivatives

专利号:EP-1519938-A2
优先权日:2002-06-27
标题:Synthesis of purine derivatives

专利号:WO-2004002990-A2
优先权日:2002-06-27
标题 :Synthesis of purine derivatives

专利号:DE-60313173-T2
优先权日:2002-06-27
标 题:SYNTHESIS OF PURIN DERIVATIVES