CAS: 17090-79-8; Monensin A

上下游产品

CAS号22373-78-0 莫能霉素钠 | CAS号1297518-94-5 | CAS号2387-23-7 N,N’-二环己基脲

Monensin A Sodium Salt置于硫酸体系中,用 二氯甲烷,水 用作溶剂,化学反应生成莫能菌素
参考文献:莫能菌素 A 与氯化钠复合物的新型 N-苯基酰胺的结构和抗菌研究
标题:莫能菌素 A 与氯化钠复合物的新型 N-苯基酰胺的结构和抗菌研究
摘要:摘要 合成了一种新型莫能菌素 A 的 N-苯基酰胺 (M-Am1) 与氯化钠的配合物,并通过 X 射线衍射和 Ft-Ir 光谱进行了研究.M-Am1 和氯化钠与乙腈的配合物的晶体结构使用 X 射线衍射进行了检查并详细讨论.其结构通过 Na+ 阳离子与氧原子的配位而稳定.Na-O 键长介于 2.382(2) 和 2.562(2) A 之间.氯阴离子参与形成超分子的不同物种之间的弱分子间氢键.Esi-Ms 光谱表明酰胺与 Na+ 阳离子形成仅 1:1 化学计量的稳定复合物.晶体的 Ft-Ir 光谱与 X 射线研究获得的结果一致,为配合物的形成提供了光谱证据.由于莫能菌素 A 的 N-苯基酰胺的特定结构特性,它可以有效地结合氯化钠.Pm5 半经验计算的结果与光谱数据一致,并允许可视化 M-Am1-Na+ 复合物的结构.鉴于其抗菌特性,莫能菌素 A 的新酰胺已经过额外测试.它对某些革兰氏阳性菌菌株显示出很大的活性(mic
Doi:10.1016/j.Molstruc.2009.01.056

专利信息

专利号:US-4670563-A
优先权日:1984-06-20
标题 :Imidazolides as intermediates for the synthesis of cytotoxic conjugates
发明人：JANSEN FRANZ; GROS PIERRE
权利人:SANOFI SA
摘要:Imidazolides of the formula: ##STR1## in which: E represents an inert spacing structure; and n G represents a group: ##STR2## or a group --S--S--X, in which X is an activating group. Application: synthesis of cytotoxic conjugates.

专利号:US-7255989-B1
优先权日:1999-11-29
标 题:Method for obtaining nucleic acids from an environment sample, resulting nucleic acids and use in synthesis of novel compounds
发明人：JEANNIN PASCALE; PERNODET JEAN-LUC; GUERINEAU MICHEL; SIMONET PASCAL; COURTOIS SOPHIE; CAPPELLANO CAMELA; FRANCOU FRANCOIS; RAYNAL ALAIN; BALL MARIA; SEZONOV GUENNADI; TUPHILE KARINE; FROSTEGARD ASA
权利人:AVENTIS PHARMA SA
摘要:The invention concerns a method for preparing nucleic acids from an environment sample, more particularly a method for obtaining a library of nucleic acids from a sample. The invention also concerns nucleic acids of nucleic acid libraries obtained by said method their use in the synthesis of novel compounds, in particular novel compounds of therapeutic interest. The invent further concerns novel means used in the method for obtaining said nucleic acids, such as novel vectors and novel processes for preparing such vectors or recombinant host cells containing said nucleic acid. Finally, the invention concerns methods for detecting a nucleic acid of interest within a library of nucleic acids resulting from said method, and nucleic acids detected by said method and polypeptides encoded by said nucleic acids.

专利号:EP-0799313-A2
优先权日:1994-12-13
标 题 :Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses
发明人：BEIGELMAN LEONID; STINCHCOMB DANIEL T; JARVIS THALE; DRAPER KENNETH; PAVCO PAMELA; MCSWIGGEN JAMES; GUSTOFSON JOHN; USMAN NASSIM; WINCOTT FRANCINE; MATULIC-ADAMIC JASENKA; KARPEISKY ALEXANDER; THOMPSON JAMES D; MODAK ANIL; BURGIN ALEX
权利人:RIBOZYME PHARM INC
摘要:An enzymatic nucleic acid molecule which cleaves RNA associated with development or maintenance of an arthritic condition, induction of graft tolerance or reversal of an immune response. In particular, the ribozyme sequences are directed to an mRNA encoding B7-1, B7-2, B7-3, CD40 and/or stromelysin. Also provided are ribozymes where the uracil in positions 4 and/or 7 are substituted, as well as methods for the synthesis of 2'-alkylnucleotides, 2'-O-alkylthioalkyl, or 2'-alkylthioalkylnucleotides. The application further describes a method for diprotection of RNA with aqueous ethylamine, a method for synthesis of a basic ribonucleoside mimetics, and transcription units comprising an RNA polymerase II promoter, a U6 small nuclear promoter, or an adenovirus VA1 promoter system.

专利号:US-5905091-A
优先权日:1996-07-03
标 题 :Enhancement of skin pigmentation by prostaglandins
发明人：FULLER BRYAN B
权利人:UNIV OKLAHOMA
摘要:A composition comprising a carrier and prostaglandin effective in stimulating synthesis of melanin in a human melanocyte thereby enhancing pigmentation of the human skin and optionally comprising a lysosomotropic agent, a phosphodiesterase inhibitor, and/or methylxanthines, and a method of use of the composition. Use of this composition promotes tanning of the human skin and increases photoprotection from ultraviolet radiation.

专利号:US-2008096242-A1
优先权日:2004-09-01
标 题 :Enhanced Substrate Conversion Efficiency Of Fermentation Processes
发明人：SANDERS JOHAN P M; WEUSTHUIS RUUD A; MOOIBROEK ANDREAS
权利人:AGROTECHNOLOGY AND FOOD INNOVA
摘要:The present invention relates to the field of fermentation technology. In particular the invention relates to fermentation processes for the production of a first and a second fermentation product by a single production organism wherein the first product is in a more reduced state than the substrate and the second fermentation product is in a more oxidised state than the substrate yet in a less oxidised state than the final oxidation product CO 2 , such that the concurrent synthesis of the first and second product in the organism allows recycling of reducing power and can be performed under (partially) anaerobic conditions. The invention also relates to such processes in which the first and second fermentation products are capable of forming a(n) (insoluble) complex or salt.

专利号:US-9693999-B2
优先权日:2011-01-26
标题:Small molecule RNase inhibitors and methods of use
发明人：DUNMAN PAUL M; OLSON PATRICK D; CHILDERS WAYNE
权利人:UNIV ROCHESTER; UNIV NEBRASKA; Temple University—Of the Commonwealth System of Higher Education
摘要:Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.