CAS: 16642-79-8; 3-(4-Nitrophenyl)Propanoic Acid

相似化合物

20716-25-0 2393-17-1 1664-57-9

上下游产品

3-(4-nitrophenyl)propanenitrile 3-Phenylpropionic acid cycl-isopropylidene malonate 4-nitrobenzaldehdye 3-(4-aminophenyl)propionic acid 3-(4-nitrophenyl)propanal 3-(p-nitrophenyl)propanoyl chloride N,N-dimethyl-3-(4-nitrophenyl)propanamide

3-苯基丙酸置于硝酸体系中,用 水,溶剂黄146 用作溶剂,化学反应 4.0H,以92%的收率获得3-(4-硝基苯基)丙酸
参考文献:对-叠氮基苯基-2-苯基链烷酸乙酯分子内环化合成四氢萘木质素酯及其对人肿瘤细胞系生长抑制的评价
标题:对-叠氮基苯基-2-苯基链烷酸乙酯分子内环化合成四氢萘木质素酯及其对人肿瘤细胞系生长抑制的评价
摘要:通过带有末端对-叠氮基苯基的2-苯基戊酸/ 2-苯基丁酸酸酯的氮离子的分子内环化作用可直接获得四氢萘木脂酸酯.所述p-Azidophenyl取代丁酸乙酯导致乙基spirodienone羧酸盐,而其同系物,得到戊4-(4-氨基苯基)以非常好收率-1,2,3,4-四氢化萘-1-羧酸叔丁酯.与此相反,米-叠氮基苯基取代的酯遭受三氟甲烷磺酸的芳族亲核加成.X射线晶体学明确地确定了最终产物的结构,并进行了密度泛函理论研究以合理化环化结果.评价了反应中间体和终产物抑制mcf-7(乳腺癌),Nci-H460(肺癌),Sf-268(cns癌症)和uacc-62(黑素瘤)细胞系体外生长的能力. .用的spirodienone羧酸盐,所观测到的乳腺癌,肺癌,和cns癌细胞系的生长抑制米-Nitrophenylalkyl碘化物,和p-苯基-取代的细长乙酯,即p-Nitrophenylpentanoate和p
Doi:10.1021/jm101182S

专利信息

专利号:US-9359333-B2
优先权日:2013-01-14
标 题 :Efficient process for the preparation of Lapatinib and salts thereof by means of new intermediates
发明人：FONTANA FRANCESCO; PAIO ALFREDO
权利人:F I S —FABBRICA ITALIANA SINT S P A; F I S —FABBRICA ITALIANA SINT
摘要:The present invention refers to a new efficient process for the synthesis of the active pharmaceutical ingredient Lapatinib and salts thereof. n In particular, the present synthesis is carried out employing new intermediates in which the amine function is protected by a group cleavable in basic milieu that provides a higher overall yield of the synthesis process.

专利号:US-12304894-B2
优先权日:2019-04-17
标题 :Derivatives of adamantyl oxadiazoles and pharmaceutically acceptable solvates, hydrates and salts thereof, pharmaceutical composition comprising same, synthesis method, suitable for use as effective and selective inhibitors of the reductase activity of the enzyme 11-beta dehydrogenase type 1 (11β-HSD1)
发明人：FARDELLA BELLO CARLOS ENRIQUE; LAGOS ARÉVALO CARLOS FERNANDO; VECCHIOLA CÃ?RDENAS ANDREA PAOLA; ALLENDE SANZANA FIDEL ALEJANDRO; DIETHELM VARELA BENJAMIN MANUEL; RECABARREN GAJARDO GONZALO IVAN; GONZÃ?LEZ CISTERNA PABLO MARCELO
权利人:UNIV PONTIFICIA CATOLICA CHILE
摘要:The present invention relates to compounds derived from adamantyl oxadiazoles and the pharmaceutically acceptable solvates, hydrates and salts of same. These compounds are suitable for use as effective and selective inhibitors of the reductase activity of the enzyme 11-beta dehydrogenase type 1 (11β-HSD1), as well as in the production of a drug for treating conditions and diseases such as high blood pressure, obesity, dyslipidaemia, type 2 diabetes, insulin resistance, glaucoma, metabolic syndrome, cognitive disorders, osteoporosis, immune disorders, depression and other conditions. Also provided is a pharmaceutical composition comprising the compounds and a method for preparing said composition.

专利号:US-10150111-B2
优先权日:2016-09-06
标题 :Method for catalytic synthesis of cinnamic acid with catalyst recycle

专利号:US-8338565-B2
优先权日:2008-08-20
标 题 :Macrocyclic compounds for inhibition of tumor necrosis factor alpha
发明人：LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P
权利人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P; ENSEMBLE THERAPEUTICS CORP
摘要:Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.

专利号:US-2018326410-A1
优先权日:2016-09-06
标题 :Method for catalytic synthesis of cinnamic acid with catalyst recycle

专利号:WO-2018219107-A1
优先权日:2017-05-27
标题:Engineered polypeptides and their applications in synthesis of beta-hydroxy-alpha-amino acids