CAS: 139525-77-2; 2-(7-Methoxynaphthalen-1-yl)Ethanamine Hydrochloride

相似化合物

138113-09-4 139525-77-2 138113-07-2

上下游产品

CAS号138113-08-3 2-(7-甲氧基萘-1-基)乙腈 | CAS号138113-09-4 7-甲氧基-1-萘乙胺 | CAS号1424944-39-7 N-formyl-N-(2-(... | CAS号138113-07-2 7-甲氧基萘-1-乙酰胺 | CAS号1206788-15-9 7-methoxy-1-(N-... | CAS号6836-22-2 7-甲氧基-1-萘乙酸 | CAS号6836-23-3 2-(7-methoxynap... | CAS号6836-19-7 7-甲氧基-1-萘满酮 | CAS号138112-76-2 阿戈美拉汀 | CAS号138113-09-4 7-甲氧基-1-萘乙胺 | CAS号138112-82-0 N-(2-(7-Methoxy... | CAS号138112-91-1 3,5-dichloro-N-... | CAS号138112-84-2 2-bromo-N-[2-(7... | CAS号138113-03-8 N-cyclopropylca... | CAS号138112-78-4 N-[2-(7-methoxy... | CAS号138113-02-7 N-[2-(7-methoxy... | CAS号152302-45-9 N-(2-(7-羟基萘-1-基... | CAS号686319-38-0 N-[2-(3-bromo-7...

乙酸-2-萘酯置于三乙基硅烷,Aluminum (III) Chloride,二甲酰氨基钠,四氯化钛,四丁基碘化铵,Potassium Carbonate体系中,用 甲醇,正己烷,二氯甲烷,二甲基亚砜 用作溶剂,化学反应 16.5H,反应生成2-(7-甲氧基萘-1-基)乙胺盐酸盐
参考文献:大规模制备阿戈美拉汀的简单有效方法:一种抗抑郁药
标题:大规模制备阿戈美拉汀的简单有效方法:一种抗抑郁药
摘要:摘要 描述了一种简单有效的大规模制备抗抑郁药阿戈美拉汀 (1) 的方法.阿戈美拉汀是从容易获得的廉价 2-萘酚开始以线性方式制备的.合成的关键步骤是 2-萘基乙酸酯与氯乙酰氯的 Friedel-Crafts 酰化,酮中间体的还原以及氯中间体与二甲酰胺钠的亲核置换.描述了一种系统方法,通过控制杂质将过程简化为强大的可扩展过程.图形概要
Doi:10.1080/00397911.2015.1050524

专利信息

专利号:US-8212077-B2
优先权日:2008-08-05
标 题:Process for the synthesis of agomelatine
发明人：HARDOUIN CHRISTOPHE; LECOUVE JEAN-PIERRE; BARAGNIER NICOLAS
权利人:HARDOUIN CHRISTOPHE; LECOUVE JEAN-PIERRE; BARAGNIER NICOLAS; SERVIER LAB
摘要:Process for the industrial synthesis of the compound of formula (I)

专利号:US-7498465-B2
优先权日:2004-02-13
标 题 :Process for the synthesis and crystalline form of agomelatine
发明人：SOUVIE JEAN-CLAUDE; BLANCO ISAAC GONZALEZ; THOMINOT GILLES; CHAPUIS GENEVIEVE; HORVATH STEPHANE; DAMIEN GERARD
权利人:SERVIER LAB
摘要:A process for the industrial synthesis and new crystalline form of the compound of formula (I): n nMedicinal products containing the same which are useful in treating disorders of the melatoninergic system.

专利号:US-7498466-B2
优先权日:2004-02-13
标 题 :Process for the synthesis and crystalline form of agomelatine
发明人：SOUVIE JEAN-CLAUDE; GONZALEZ BLANCO ISAAC; THOMINOT GILLES; CHAPUIS GENEVIEVE; HORVATH STEPHANE; DAMIEN GERARD
权利人:SERVIER LAB
摘要:A process for the industrial synthesis and new crystalline form of the compound of formula (I): n nMedicinal products containing the same which are useful in treating disorders of the melatoninergic system.

专利号:US-7544839-B2
优先权日:2004-02-13
标 题:Process for the synthesis and crystalline form agomelatine
发明人：SOUVIE JEAN-CLAUDE; GONZALEZ-BLANCO ISAAC; THOMINOT GILLES; CHAPUIS GENEVIEVE; HORVATH STEPHANE; DAMIEN GERARD
权利人:SERVIER LAB
摘要:Process for the industrial synthesis and new crystalline form of the compound of formula (I): n nMedicinal products containing the same which are useful in treating disorders of the melatoninergic system.

专利号:US-2012245363-A1
优先权日:2008-08-05
标题 :Process for the synthesis of agomelatine

专利号:US-2010036162-A1
优先权日:2008-08-05
标 题 :Process for the synthesis of agomelatine