CAS: 13205-48-6; 4-(Methylthio)Benzoic Acid

该化合物是一种芳香的碳酸,其特征是含有甲基硫酸组(-S-CH3),附于苯甲酸结构的副体位置,该化合物一般是白色的白色,在有机溶剂中可溶解,而其溶解于水中的溶解性则因其疏水芳香性质而受到限制.甲基硫酸组有助于其独特的化学特性,包括核糖核替代反应的潜在再活动及其在各种有机合成中作为功能组的作用.4-(甲基乙基硫)苯甲酸可用于合成药物,农用化学品和其他有机化合物,其酸性可归因于氨基酸功能组,可将其捐献给蛋白质溶解,使其变成一种弱酸.此外,该化合物可能展示出具体的生物活动,但需要详细研究,以阐明其特性和用途的全部范围.

结构式图片

相似化合物

21382-98-9 3446-89-7 3446-90-0

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CAS号124-38-9 二氧化碳 | CAS号104-95-0 4-溴硫代苯甲醚 | CAS号201230-82-2 carbon monoxide | CAS号3446-90-0 4-甲硫基苄醇 | CAS号35371-03-0 4-碘茴香硫醚 | CAS号67-56-1 甲醇 | CAS号5969-48-2 methyl 4-(methy... | CAS号1074-36-8 4-巯基苯甲酸 | CAS号616-38-6 碳酸二甲酯 | CAS号38185-19-2 4-(甲硫基)溴苄 | CAS号40517-43-9 1-(氯甲基)-4-(甲基磺酰基)苯 | CAS号4052-30-6 4-甲砜基苯甲酸 | CAS号3446-90-0 4-甲硫基苄醇 | CAS号33963-58-5 4-甲亚砜基苯甲酸 | CAS号1442-06-4 4-(甲硫基)苯甲酰氯 | CAS号3795-79-7 4-(甲基硫代)苯甲酸甲酯 | CAS号25771-25-9 N,N-dimethyl-4-... | CAS号77671-31-9 依诺昔酮

合成工艺路线路线简述

    4-Methylmercapto-Dithiobenzoesaeure-Methylester置于sodium Hydroxide,双氧水体系中,用 甲醇,水 用作溶剂,化学反应 0.08H,以86%的收率获得4-甲硫基苯甲酸
    参考文献:使用碱性过氧化氢将二硫酯轻松转化为羧酸或酯
    标题:使用碱性过氧化氢将二硫酯轻松转化为羧酸或酯
    摘要:描述了在碱性条件下使用过氧化氢将二硫酯直接转化为羧酸或酯的简单,温和和环保的程序.
    Doi:10.1055/s-0028-1083190

    海关参考信息

    专利信息


    专利号:US-6245937-B1
    优先权日:1996-11-29
    标题 :Liquid phase parallel synthesis of chemical libraries
    发明人:CHENG SOAN; SAUNDERS JOHN
    权利人:DUPONT PHARMACEUTICALS RES LAB
    摘要:This invention features methods of biphasic synthesis for synthesizing combinatorial libraries and combinatorial libraries of chemical compounds utilizing the template, and combinatorial libraries of chemical compounds formed by the methods of this invention.

    专利号:US-8202985-B2
    优先权日:2005-10-31
    标 题:Monomer compositions for the synthesis of polynucleotides, methods of synthesis, and methods of deprotection
    发明人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINO; CARUTHERS MARVIN H
    权利人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINO; CARUTHERS MARVIN H; AGILENT TECHNOLOGIES INC; UNIV COLORADO
    摘要:Nucleotide monomers, polynucleotides, methods of making each, and methods of deprotecting each, are disclosed. An embodiment of the nucleotide monomer, among others, includes a nucleotide monomer having a heterobase protecting group selected from structures I through III as described herein. An embodiment of the polynucleotide, among others, includes a plurality of nucleotide moieties having a heterobase protecting group selected from one of structures I through III as described herein.

    专利号:US-7759471-B2
    优先权日:2005-10-31
    标题 :Monomer compositions for the synthesis of RNA, methods of synthesis, and methods of deprotection
    发明人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINE; CARUTHERS MARVIN H
    权利人:AGILENT TECHNOLOGIES INC; UNIV COLORADO
    摘要:Nucleotide monomers, polynucleotides, methods of making each, methods of deprotecting each, and the like are disclosed herein.

    专利号:US-8138272-B2
    优先权日:2006-05-22
    标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
    发明人:KONRADI ANDREI W; SMITH JENIFER L
    权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
    摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.

    专利号:US-6291709-B1
    优先权日:1998-12-28
    标题:Solid supported synthesis of hydroxamic acids
    发明人:GOLEBIOWSKI ADAM; KLOPFENSTEIN SEAN REES
    权利人:PROCTER & GAMBLE
    摘要:The subject invention involves processes for making hydroxamic acid compounds using a solid-support resin having an oxime moiety as the linking moiety of the resin, comprising the steps of (a) treating the resin with a carboxylic acid compound, such that it is attached to the resin by a condensation reaction between the oxime and carboxyl moieties; (b) optionally modifying the side chain; (c) cleaving a product from the resin by treating with O-tert-butyldimethylsilylhydroxylamine; (d) optionally modifying the side chain; and (e) optionally treating the resulting O-TBS-protected material with acid to produce an unprotected hydroxamic acid compound.

    专利号:US-2007100138-A1
    优先权日:2005-10-31
    标题:Monomer compositions for the synthesis of polynucleotides, methods of synthesis, and methods of deprotection
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    主要参考文献

    [参考文献]: P J Boogaard, Et Al. 4-Methylthiobenzoic Acid Reduces Cisplatin Nephrotoxicity In Rats Without Compromising Anti-Tumour Activity. Biochem Pharmacol. 1991 Jun 15;41(12):1997-2003.

    合成参考文献


    参考文献:10.1107/s1600536810035336
    摘要:Jiang GQ, Chen JH, Wang M, Shi YJ. Aqua-bis-[4-(methyl-sulfan-yl)benzoato-κO]bis-(pyridine-κN)copper(II). Acta Crystallogr Sect E Struct Rep Online. 2010 Sep 08;66(Pt 10):m1219.
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