CAS: 129558-76-5; Tolfenpyrad

该化合物是一种化学化合物,被归类为衍生物,主要用作农药,特别是在农业应用中;它作为一种杀虫剂和杀虫剂,针对一系列害虫,同时对非目标生物,包括受益昆虫的毒性较低;Tolfenprirad通过一种独特的行动方式运作,抑制干扰害虫能源生产的线粒体呼吸;该化合物的特点是波动性和稳定性相对较低,适合各种配方;它通常用于作物保护,以有效管理害虫口;此外,Tolfenpyrad具有有利的环境特征,因为它往往在环境中降解,减少长期生态影响的风险;然而,就所有杀虫剂而言,它的使用受到管制,并建议采取安全措施,以尽量减少对人类和野生动物的接触;总的来说,Tolfenpyrad是综合虫害管理战略中的宝贵工具,有助于可持续农业做法.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

1-methyl-3-ethyl-4-chloro-1H-pyrazol-5-ylformylic acid chloride (4-(p-tolyloxy)phenyl)methanamine 4-(4-methylphenoxy)benzylamine hydr°Chloride p-cresol

合成工艺路线路线简述

    4-(4-甲基苯氧基)苯甲腈置于硫酸,氨,氢气体系中,用 甲醇,甲苯 用作溶剂,55.0 °C,3.5 Mpa 条件下,反应 11.0H,反应生成唑虫酰胺
    参考文献:一种取代的苯氧基苄胺类化合物及吡唑羧酰胺类化合物的制备方法
    标题:一种取代的苯氧基苄胺类化合物及吡唑羧酰胺类化合物的制备方法
    摘要:本发明公开了一种取代的苯氧基苄胺类化合物的制备方法,以对卤苯腈为起始原料,在r'om存在的条件下以r'oh用作溶剂并经氢气还原得到取代的苯氧基苄胺类化合物,具有收率高,纯度高的优点;本发明还公开了一种吡唑羧酰胺的制备方法,通过将取代的苯氧基苄胺类化合物先成盐再与取代的吡唑酰氯化合物反应从而以出人预料的高收率制得吡唑羧酰胺类化合物.本发明技术方案具有产品纯度高,收率高,溶剂损耗低,生产成本低的优点.

    海关参考信息

    专利信息


    专利号:WO-2025056767-A1
    优先权日:2023-09-15
    标题 :Process for the preparation of enantiomerically enriched aliphatic amines
    发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

    专利号:US-10906880-B2
    优先权日:2016-01-26
    标题:Kind of isothiazole oxime ether-containing strobilurin derivatives and its preparation methods and application
    发明人:FAN ZHIJIN; CHEN LAI; GUO XIAOFENG; ZHU YUJIE; QIAN XIAOLIN; MA LIUYONG; ZHANG NAILOU; WANG HAIXIA; ZHANG ZHIMING; XU JINGHUA; SONG YINQI
    权利人:UNIV NANKAI
    摘要:The present invention is that provided a synthesis method of a series of isothiazole oxime ether containing strobilurin derivatives IV. The present invention relates to 3,4-dichloroisothiazolyl oxime ether strobilurin derivatives, and their chemical structural formula is as shown by IV. n n n n n n n n n n The invention discloses the structural formula of the above compound, the synthesis method and the use as an insecticide, a fungicide, an anti-plant virus agent, and an agriculturally acceptable auxiliary or synergist and a commercial insecticide. The use of a fungicide, an anti-plant virus agent and an acaricide in combination for controlling agricultural, forestry, horticultural plant pests, diseases, virus diseases and preparation methods.

    专利号:US-2007232495-A1
    优先权日:2006-03-24
    标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
    发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
    摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

    专利号:WO-2021074309-A1
    优先权日:2019-10-16
    标 题:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives as fungicides for combating specific phytopathogens
    发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; SEN INDIRA; BIERI STEPHANE; DIGGELMANN MARTIN
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-3,4-dihydroisoquinoline derivative of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale) when spayed on plants), as well as comparative data against three prior art compounds (e.g. pages 52 to 85; formulation examples; examples A1 to A3; table E; compounds E.01 to E.187; biological examples). Exemplary compounds are e.g.: 5-bromo-1-(8-fluoro-3-quinolyl)spiro[4H-isoquinoline-3,1'- cyclopropane] (example A1) 5-bromo-1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline (example A2) 1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline-5-carbonitrile (example A3)

    专利号:WO-2021074311-A1
    优先权日:2019-10-16
    标题:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives as fungicides for combating specific phytopathogens
    发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; BIERI STEPHANE; DIGGELMANN MARTIN
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola, Monographella nivalis, Fusarium culmorum and/or Gibberella zeae when spayed on plants) (e.g. pages 47 to 55; examples A1 and A2; compounds E.01 to E.17; table E). An exemplary compounds is e.g.: 3-(5-bromo-3,3-dimethyl-2,4-dihydro-1 H-isoquinolin-1-yl)-8-fluoro- quinoline (example A1)

    专利号:US-2011230343-A1
    优先权日:2008-10-24
    标题 :Method for the Manufacture of Microparticles Comprising an Effect Substance
    发明人:SCHROERS MICHAEL; DYLLICK-BRENZINGER RAINER; MERK MICHAEL; BARG HEIKO
    权利人:BASF SE
    摘要:A subject matter of the present invention is a process for the preparation of effect compound-comprising microparticles M comprising A) the formation of a crude suspension of microparticles A by means of enzymatic polyester synthesis in an inverse miniemulsion comprising enzyme, effect compound and polyester monomers; and B) the polymerization of wall monomers from the group consisting of ethylenically unsaturated monomers, polyisocyanates and polyepoxides in the crude suspension of microparticles A. Furthermore, the present invention relates to microparticles M which can be obtained by means of the process according to the invention and also to an agrochemical formulation comprising microparticles M. In addition, the present invention relates to the use of microparticles M prepared according to the invention as component in colorants, cosmetics, drugs, biocides, plant protection agents, fertilizers, additives for food or animal fodder, or auxiliaries for polymers, paper, textiles, leather, detergents or cleaners. Finally, the invention also relates to a method for combating undesirable plant growth, to a method for combating undesirable insect or acarid infestation on plants and/or for combating phytopathogenic fungi, and to seeds treated with the agrochemical formulation.
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    主要参考文献


    1: Le T, Kundu A, Ghoshal A, Nguyen N, Preston S, Jiao Y, Ruan B, Xue L, Huang F, Keiser J, Hofmann A, Chang B, Garcia-Bustos J, Wells TNC, Palmer MJ, Jabbar A, Gasser RB, Baell JB. Structure-activity relationship studies of tolfenpyrad reveal sub-nanomolar inhibitors of Haemonchus contortus development. J Med Chem. 2018 Dec 20. doi: 10.1021/acs.jmedchem.8b01789. [Epub ahead of print] doi: 10.1016/j.foodchem.2018.07.005. Epub 2018 Jul 2. doi: 10.1016/j.ijpddr.2017.11.004. Epub 2017 Dec 2.
    4: Cloyd RA, Herrick NJ. Effects of Pesticides on the Survival of Rove Beetle (Coleoptera: Staphylinidae) and Insidious Flower Bug (Hemiptera: Anthocoridae) Adults. J Econ Entomol. 2018 Feb 9;111(1):78-88. doi: 10.1093/jee/tox280. doi: 10.1002/ps.4639. Epub 2017 Aug 9. doi: 10.1186/s13071-017-2191-8.
    7: Echegaray ER, Vinchesi AC, Rondon SI, Alvarez JM, McKinley N. Potato Psyllid (Hemiptera: Triozidae) Response to Insecticides Under Controlled Greenhouse Conditions. J Econ Entomol. 2017 Feb 1;110(1):142-149. doi: 10.1093/jee/tow259. English, Japanese. doi: 10.1016/j.ijpddr.2016.07.004. Epub 2016 Jul 28. Review.

    合成参考文献


    参考文献:10.1007/s11274-019-2676-z
    摘要:Mahmood A, Takagi K, Ito K, Kataoka R. Changes in endophytic bacterial communities during different growth stages of cucumber (Cucumis sativus L.). World Journal of Microbiology and Biotechnology. 2019 Jun 24;35(7):104. doi: 10.1007/s11274-019-2676-z.
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