CAS: 119-80-2; 2,2'-Dithiodibenzoic Acid

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硫代水杨酸置于3,6-二-2-吡啶基-1,2,4,5-四嗪体系中,用 乙醇,水 用作溶剂,化学反应 0.08H,以98%的收率获得2,2'-二硫代二苯甲酸
参考文献:3,6-二(吡啶-2-基)-1,2,4,5-四嗪(pytz)介导的水介质中巯基无金属轻度氧化为二硫化物
标题:3,6-二(吡啶-2-基)-1,2,4,5-四嗪(pytz)介导的水介质中巯基无金属轻度氧化为二硫化物
摘要:在3,6-二(吡啶-2-基)-1,2,4,5-四嗪(pytz)的存在下,在温和的条件下以及无溶剂的情况下,硫醇可有效地氧化为二硫化物(rssr).和无金属的条件.国外...
Doi:10.1039/c6Ra01509C

专利信息

专利号:US-4042600-A
优先权日:1972-10-17
标 题 :Pyrolysis of 2-sulfochloride benzoates
发明人：DIPIPPO CARMINE A
权利人:SCOTT PAPER CO
摘要:Ortho-sulfobenzoic anhydride is synthesized by pyrolysis of the 2-sulfochloride benzoates. The benzoate intermediates are readily prepared by reacting either the esters of dithiodibenzoic acid with chloride water or the 2-diazonium chloride benzoates with sulfur dioxide. The invention also provides for the total synthesis of saccharin, free of bitter tasting contaminants, from such reactants, the ultimate step in such synthesis being the ammonolysis of the o-sulfobenzoic anhydride.

专利号:US-4259499-A
优先权日:1972-10-17
标 题:Method for preparing 2-sulfochloride benzoates and the use of same in the preparation of saccharin
发明人：DIPIPPO CARMINE A
权利人:JAMES RIVER GRAPHICS INC
摘要:A method of preparing 2-sulfochloride benzoates which comprises diazotizing any anthranilate to form a 2-diazonium chloride benzoate and thereafter reacting said 2-diazonium chloride benzoate with sulfur dioxide to form a 2-sulfochloride benzoate. The invention also provides for the total synthesis of saccharin which comprises pyrolyzing a 2-sulfochloride benzoate to form an o-sulfobenzoic anhydride and then ammonolyzing the o-sulfobenzoic anhydride to saccharin which is free of bitter tasting contaminants from such reactants.

专利号:WO-9722598-A1
优先权日:1995-12-15
标 题 :Method of making (s-(r*,r*))-3-methyl-2-(3-oxo-3h-benzo(d)isothiazol-2-yl)pentanoic acid and (s-(r*,r*)), l-2-(2-(2-(1-carboxy-2-methylbutylcarbamoyl)phenyldisulfonyl)benzoyl-amino)-3-methylpentanoic acid
发明人：FIORE PHILLIP; PULS TIMOTHY P; WALKER JONATHAN
权利人:WARNER LAMBERT CO; FIORE PHILLIP; PULS TIMOTHY P; WALKER JONATHAN
摘要:The present application discloses a synthesis of [S-(R*,R*)]-3-methyl-2-(3-oxo-3H-benzo[d]-isothiazol-2-yl)pentanoic acid and [S-(R*,R*)], L-2-{2-[2-(1-carboxy-2-methylbutylcarbamoyl)phenyldisulfonyl]-benzoylamino}-3-methylpentanoic acid.

专利号:WO-0053577-A9
优先权日:1999-03-12
标 题:Hydrazide inhibitors of hiv-1 integrase
发明人：NEAMATI NOURI; POMMIER YVES; LIN ZHAIWEI; BURKE TERRENCE
权利人:US GOV HEALTH & HUMAN SERV; NEAMATI NOURI; POMMIER YVES; LIN ZHAIWEI; BURKE TERRENCE
摘要:The design, synthesis and antiviral activity of novel mercaptosalicylhydrazides are disclosed, which inhibit human immunodeficiency virus type-1 integrase (HIV-1 IN), an essential enzyme for effective viral replication. Examples of the compounds are N,N'-bis(2-mercaptobenzoyl)hydrazide, N,N'-bis(2,2'-dithiosalicyl)hydrazide, and N,N'-bis(2-mercaptobenzyl)-2,2'-dithiosalicylhydrazide. These compounds are effective against the integrase catalytic core domain, inhibit integrase binding to HIV LTR DNA, and inhibit integrase in preassmbled integrase-DNA complexes. The disclosed mercaptosalicylhydrazides are 300 fold less cytotoxic than other known salicylhydrazides, and exhibit antiviral activity. They are also active in Mg+2-based assays, while integrase inhibition by salicylhydrazides is strictly Mn+2-dependent. The mercaptosalicylhydrazides have no detectable effect on other retroviral targets, including reverse transcriptase, protease, and virus attachment, and exhibit no detectable activity against human topoisomerase I at concentrations that effectively inhibited integrase. The mercaptosalicylhydrazides of the invention are therefore selective inhibitors of HIV-1 integrase, are useful in therapeutic compositions for the treatment of HIV disease, and can also be used to find related antiviral drugs.

专利号:BE-888335-A
优先权日:1981-04-09
标 题:SYNTHESIS OF THREE NEW PHARMACEUTICAL PRODUCTS OBTAINED BY SCIENTIFIC REACTIONS FROM 2,2'-DITHI DIBENZOIC ACID.

专利号:WO-02062887-A1
优先权日:2001-02-02
标题:Design and synthesis of instant-degradable plastics