氨基胍碳酸氢盐置于硝酸体系中,化学反应生成氨基胍硝酸盐 参考文献:Hegarty,A.F. Et Al.,Journal Of The Chemical Society. Perkin Transactions Ii,1973,P. 2054-2060 标题:Hegarty,A.F. Et Al.,Journal Of The Chemical Society. Perkin Transactions Ii,1973,P. 2054-2060
专利信息
专利号:US-2025100979-A1 优先权日:2023-09-25 标 题:Synthesis of a tetrazole derivative 发明人:PRADHAN BRAJA SUNDAR; MEHTA NEHA; PATEL KEYUR 权利人:PRADHAN BRAJA SUNDAR; MEHTA NEHA; PATEL KEYUR 摘要:Embodiments of this disclosure describe a novel method for synthesizing a tetrazole derivative. The distinguishing feature lies in using aminoguanidine nitrate or aminoguanidine bicarbonate as the starting material, replacing the highly sensitive tetrazine. In a single operational step, the aqueous solution of the starting material is treated with sodium nitrite. The treatment resulted in the precipitation a solid product. Without isolating the intermediate, the solid is subjected undergoes Sandmeyer reaction conditions in-situ, involving nitric acid and sodium nitrite. The resulting solid is filtered, washed with cold water and isopropyl alcohol, and dried to obtain the tetrazole derivative. By eliminating the safety risks associated with the Hamiltonian precursor and streamlining the process, the invention offers a safer, more efficient, and commercially viable method for synthesizing the tetrazole derivative.
专利号:US-7034154-B2 优先权日:1999-08-10 标 题:Synthesis of substituted pyrazolopyrimidines 发明人:GROSS RAYMOND S; WILCOXEN KEITH M; OGLESBY RICHARD CHRISTOPHER 权利人:NEUROCRINE BIOSCIENCES INC 摘要:Methods of making substituted pyrazolopyrimidines generally and, more particularly, N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide. Such compounds have utility over a wide range of indications, including treatment of insomnia. In the practice of the present invention, improved techniques which do not require use and/or isolation of the pyrazole intermediate are disclosed, as well as improved techniques for making the reaction intermediates themselves. Such techniques offer significant advantages, including enhanced efficiency, particularly in the context of large scale manufacture.
专利号:US-10836731-B2 优先权日:2017-02-28 标 题 :Precipitation method and synthesis method of 2,6-diamino-3,5-dinitropyrazine-1-oxide 发明人:PASQUINET ERIC; WUILLAUME ANNE; PIN NICOLAS; BEAUCAMP ARNAUD; BARTHET CHRISTELLE 权利人:COMMISSARIAT ENERGIE ATOMIQUE 摘要:A method for precipitating as particles 2,6-diamino-3,5-dinitropyrazine-1-oxide (or ANPZO) present in an acid medium, which comprises adding the acid medium to an aqueous solution and which is characterized in that the aqueous solution comprises a nitrate salt. Further disclosed is a method for synthesizing ANPZO implementing this precipitation method. The synthesis method comprises converting 2,6-diaminopyrazine-1-oxide (or DAPO) into ANPZO by nitration in an acid medium, and then precipitating as particles the ANPZO by adding the acid medium to an aqueous solution, and is characterized in that the aqueous solution comprises a nitrate salt.
专利号:US-6077371-A 优先权日:1997-02-10 标 题 :Gas generants comprising transition metal nitrite complexes 发明人:LUNDSTROM NORMAN H; BEGIN LAURENCE C 权利人:AUTOMOTIVE SYSTEMS LAB 摘要:High nitrogen gas generant compositions, useful for inflating passenger restraint gas inflator bags, comprise a nitrogen rich coordination compound selected from coordination complexes comprised of anionic nitro and nitrito ligands coordinated with a transitional metal template, and nonmetallic or nonmetallic/metallic cations. The gas generant compositions generate relatively more gas and less solids, and are safer than known gas generant compositions. Certain gas generant compositions ignite at lower autoignition temperatures thereby facilitating the use of an aluminum or light weight metal pressure vessel. Other gas generants self-deflagrate eliminating the need for other constituents in the composition. Novel methods for the synthesis of nonmetal derivative coordination complexes, guanidine and hydrazine for example, are also presented.
专利号:US-8097103-B2 优先权日:2009-06-18 标 题 :Copper complexes with oxalyldihydrazide moieties 发明人:TAYLOR ROBERT D; HESS GREGG 权利人:TAYLOR ROBERT D; HESS GREGG; AUTOLIV ASP INC 摘要:Methods of making and resultant compositions thereof, which include copper-oxalyldihydrazide-based complexes, such as pyrotechnic compositions, gas generants, and ignition materials, which are useful, for example, in inflatable restraint systems. Synthesis of one or more copper-oxalyldihydrazide complexes with nitrate and/or hydroxide counter ions provides a composition that may auto-ignite at a low enough temperature to be based with thermally sensitive gas generants. The present copper-oxalyldihydrazide complexes may also be used in conjunction with various oxidizers to produce compositions with sufficient energy to auto-ignite practically any known pyrotechnic composition.
专利号:EP-1208102-A1 优先权日:1999-08-10 标 题 :Synthesis of substituted pyrazolopyrimidines
参考标题:General And Greener Synthesis Of Diverse Functional Organic Salts Through Schiff Base Chemistry 作者:Baoping Hu,Qingrong Shi,Feipeng Lu,Pengcheng Zhang,Panpan Peng,Chaofeng Zhao,Yao Du,Hui Su,Shenghua Li,Siping Pang,Fudie Nie |发布日期:2019.5 摘要:We Report A Greener And More-General Organic Method For The Synthesis Of Functional Organic Salts Containing Organic Anions Through A Schiff Base Reaction Between Readily Available Aldehydes And Simple Aminoguanidinium Salts. This Reaction Is Operationally Simple, Free Of Metal Salts, And Forms Water As The Sole Byproduct. The Broad Scope And Good Functional-Group Compatibility Of This Method Permit
合成参考文献
参考文献:10.1007/s10934-022-01414-y 摘要:Eftekhar M, Khosravi I. CoII immobilized on aminated mesoporous SBA-16 (SBA-16/GPTMS-NH2–CoII): a highly efficient mesostructured catalyst for the C–O bond formation under solvent-free conditions. J Porous Mater. 2023 Jan 09;30(4):1255–72. doi: 10.1007/s10934-022-01414-y.