CAS: 101692-01-7; (1R,2R,3As,9As)-1-[(3S)-3-Hydroxyoctyl]-5-Methoxy-2,3,3A,4,9,9A-Hexahydro-1H-Cyclopenta[b]Naphthalen-2-Ol

该化合物是来自Treprostinil的合成蛋白环环类类,其特点是没有碳化物组,这种结构改变增强了其代谢稳定性和生物利用率,与母体化合物相比,它增加了代谢稳定性和生物利用率.它展示了强大的血管和抗板聚合特性,使它成为治疗肺动脉高血压(PAH)和其他血管紊乱的候选体.该化合物的改良药理动能剖面使得其治疗效果更加一致,并有可能降低剂量频率.它的行动机制包括激活IP受体,导致循环AMP的平稳肌肉放松.Descarboxy Treprostinil正在临床环境中对其有效性和安全性进行调查.

英文名称(1R,2R,3As,9As)-1-[(3S)-3-Hydroxyoctyl]-5-Methoxy-2,3,3A,4,9,9A-Hexahydro-1H-Cyclopenta[b]Naphthalen-2-Ol
中文名称(1R,2R,3AS,9AS)-2,3,3A,4,9,9A-六氢-1-[(3S)-3-甲氧基辛基]-1H-苯并[F]茚-2,5-二醇
其它别名Treprostinil Intermediate; (Alphas,1R,2R,3As,9As)-2,3,3A,4,9,9A-Hexahydro-2-Hydroxy-5-Methoxy-Alpha-Pentyl-1H-Benz[f]Indene-1-Propanol; (1R,2R,3As,9As)-1-(2-Hydroxyoctyl)-5-Methoxy-2,3,3A,4,9,9A-Hexahydro-1H-Cyclopenta[b]Naphthalen-2-Ol; (1R,2R,3As,9As)-1-((S)-3-Hydroxyoctyl)-5-Methoxy-2,3,3A,4,9,9A-Hexahydro-1H-Cyclopenta[b]Naphthalen-2-Ol; (1R,2R,3As,9As)-1-((S,E)-3-Hydroxyoct-1-En-1-yl)-5-Methoxy-2,3,3A,4,9,9A-Hexahydro-1H-Cyclopenta[b]Naphthalen-2-Ol; Descarboxy Treprostinil; Treprostinil Impurity 2; Treprostinil Impurity 1
CAS编号101692-01-7
MFCD编号:MFCD30478440
分子式:C22H34O3
分子量:346.5
产品CID: 33272

相似结构搜索
1S/C22H34O3/c1-3-4-5-8-17(23)10-11-18-19-12-15-7-6-9-22(25-2)20(15)13-16(19)14-21(18)24/h6-7,9,16-19,21,23-24H,3-5,8,10-14H2,1-2H3/t16-,17-,…
计算化学: 氢键受体数*氢键供体数*可旋转键数*

MSDS等安全信息

警示词warning
危险描述H303+H313+H333
防范说明P264+P280+P305+P351+P338+P337+P313
安全声明H303+H313+H333

上下游产品

2-allyl-3-methoxybenzaldehyde(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-1-((S)-3-hydroxy°Ctyl)-1H-cyclopenta[b]naphthalene-2,5-diol treprostinil 2-((1R,2R,3aS,9aS)-2-hydroxy-1-(S)-3-hydroxy°Ctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalene-5-yloxylacetic acid ethyl ester 2-(((1R,2R,3aS,9aS)-2-hydroxy-1-((S)-3-hydroxy°Ctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetic acid diethanolamine salt