CAS: 1002309-52-5; 1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Pyridin-2(1H)-One

相似化合物

1083169-01-0 1349151-98-9 1349734-00-4

上下游产品

CAS号81971-39-3 1-甲基-5-溴吡啶-2(1H)-酮 | CAS号73183-34-3 双戊酰二硼 | CAS号1159607-48-3 3 -bromo-4-phen... | CAS号124-63-0 甲基磺酰氯 | CAS号1054483-78-1 6-羟基吡啶-3-硼酸频哪醇酯 | CAS号74-88-4 碘甲烷 | CAS号445264-61-9 2-甲氧基吡啶-5-硼酸频哪醇酯

2-羟基-5-溴吡啶置于(1,1'-Bis(Diphenylphosphino)Ferrocene)Palladium(II) Dichloride,Potassium Acetate,Caesium Carbonate体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 21.0H,反应生成1-甲基-6-氧代-1,6-二氢吡啶-3-硼酸频那醇酯
参考文献:合成和评价硫代甘露糖苷,有效和口服活性的fimh抑制剂
标题:合成和评价硫代甘露糖苷,有效和口服活性的fimh抑制剂
摘要:Fimh是一种i型纤维凝集素,位于革兰氏阴性尿路致病性大肠杆菌(upec)的1型菌毛末端,指导其粘附和感染尿道上皮细胞的能力.因此,用小分子抑制剂阻断fimh被认为是治疗由upec引起的尿路感染的有前途的新治疗选择.本文中,我们报道口服给药时具有s-糖苷键的化合物(硫甘露糖苷)具有改善的代谢稳定性和血浆暴露.特别是化合物5H显示出抑制生物膜形成并破坏预形成的生物膜的潜力.化合物5H在小鼠uti模型中具有预防作用.
Doi:10.1016/j.Bmcl.2018.06.017

专利信息

专利号:WO-2025128848-A1
优先权日:2023-12-12
标题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

专利号:US-2025026766-A1
优先权日:2022-01-12
标题 :Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors
发明人：LI JING; XU WENQING; WANG ZHIWEI
权利人:BEIGENE LTD
摘要:The present invention relates to compounds containing thiazolopyridyl amide structure, the process for their synthesis, as well as the use of such compounds for inhibiting DNA Polymerase Theta (Pol Theta), and in the treatment of various diseases including cancers.