CAS: 94-47-3; Phenethyl Benzoate

该化合物是一种合成酯化合物,由苯乙醇和苯甲酸凝聚形成,其特征是清晰,无色至黄色色色,具有轻度的花岗香.该酯在标准条件下具有稳定性,具有低挥发性,与一系列有机溶剂相容性,适合用于香味配方和调味剂.其化学惰性及对水解的耐受性有助于其长期应用.苯乙酸乙酯还被用作香水中的固定剂和有机合成的中间体.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

CAS号60-12-8 苯乙醇 | CAS号93-97-0 苯甲酸酐 | CAS号93-58-3 苯甲酸甲酯 | CAS号98-88-4 苯甲酰氯 | CAS号65-85-0 苯甲酸 | CAS号94-36-0 过氧化苯甲酰 | CAS号93-99-2 苯甲酸苯酯 | CAS号120-46-7 二苯甲酰甲烷 | CAS号3277-27-8 苯甲酰膦酸二乙酯 | CAS号98-85-1 苏合香醇 | CAS号60-12-8 苯乙醇 | CAS号614-16-4 苯甲酰乙腈 | CAS号65-85-0 苯甲酸 | CAS号93-58-3 苯甲酸甲酯

合成工艺路线路线简述

  • 65-85-0 + 4138-35-6 = 94-47-3
    反应条件:1.1 Reagents: Tert-Butyl Nitrite Solvents: Carbon Tetrachloride; 5 H,60 °C
    标题:Carboxylic Acid O-H Insertion Reaction Of β-Ester Diazos Enabling Synthesis Of β-Acyloxy Esters
    作者:Li,Ziyi; Yao,Xinyu; Zhang,Xin; Mei,Haibo; Han,Jianlin
    参考文献:Journal Of Organic Chemistry 日期:2022 卷标:87(22) 页码:15483-15491]

    93-58-3 + 60-12-8 = 94-47-3
    反应条件:1.1 Catalysts: Zirconium,Bis(η5-2,4-Cyclopentadien-1-Yl)Bis(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-...; 22 H,85 °C
    标题:Process For Direct Esterification And Transesterification Reactions In The Presence Of High Efficiency Catalyst
    参考文献:China]

    93-97-0 + 60-12-8 = 94-47-3
    反应条件:1.1 Catalysts: Molybdenum Chloride Oxide (Mocl2O2),(T-4)- Solvents: Dichloromethane; Rt; 30 Min,Rt1.2 27 H,Rt1.3 Reagents: Water; Cooled
    标题:Nucleophilic Acyl Substitutions Of Anhydrides With Protic Nucleophiles Catalyzed By Amphoteric,Oxomolybdenum Species
    作者:Chen,Chien-Tien; Kuo,Jen-Huang; Pawar,Vijay D.; Munot,Yogesh S.; Weng,Shieu-Shien; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(4) 页码:1188-1197]

    93-97-0 + 60-12-8 = 94-47-3
    反应条件:1.1 Catalysts: Zinc Perchlorate Hexahydrate Solvents: Diethyl Ether; 1 H,Reflux; Reflux -> Rt1.2 Reagents: Sodium Bicarbonate Solvents: Diethyl Ether,Water; 30 Min,Rt
    标题:Zn(Clo4)2.6H2O As A Powerful Catalyst For A Practical Acylation Of Alcohols With Acid Anhydrides
    作者:Bartoli,Giuseppe; Bosco,Marcella; Dalpozzo,Renato; Marcantoni,Enrico; Massaccesi,Massimo; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2003 卷标:(23) 页码:4611-4617]

    14629-58-4 + 93-97-0 = 94-47-3
    反应条件:1.1 Catalysts: Bismuth Triflate Solvents: Acetonitrile
    标题:Efficient And Selective Conversion Of Trimethylsilyl And Tetrahydropyranyl Ethers To Their Corresponding Acetates And Benzoates Catalyzed By Bismuth(Iii) Salts
    作者:Mohammadpoor-Baltork,Iraj; Khosropour,Ahmad R.
    参考文献:Monatshefte Fuer Chemie 日期:2002 卷标:133(2) 页码:189-193]

    93-97-0 + 60-12-8 = 94-47-3
    反应条件:1.1 Catalysts: Bis(η5-2,4-Cyclopentadien-1-Yl)Bis(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Heptadecafl...; 1 H,Rt
    标题:Air-Stable Titanocene Bis(Perfluorooctanesulfonate) As A New Catalyst For Acylation Of Alcohols,Phenols,Thiols,And Amines Under Solvent-Free Condition
    作者:Qiu,Ren-Hua; Zhang,Guo-Ping; Ren,Xiao-Fang; Xu,Xin-Hua; Yang,Rong-Hua; Et Al
    参考文献:Journal Of Organometallic Chemistry 日期:2010 卷标:695(8) 页码:1182-1188]

    93-97-0 + 60-12-8 = 94-47-3
    反应条件:1.1 Catalysts: Bismuth Triflate Solvents: Acetonitrile
    标题:Bismuth(Iii) Salts As Convenient And Efficient Catalysts For The Selective Acetylation And Benzoylation Of Alcohols And Phenols
    作者:Mohammadpoor-Baltork,I.; Aliyan,H.; Reza Khosropour,A.
    参考文献:Tetrahedron 日期:2001 卷标:57(27) 页码:5851-5854]

    78926-09-7 + 98-88-4 = 94-47-3
    反应条件:1.1 Reagents: Zinc Chloride
    标题:Facile Conversion Of Tetrahydropyranyl And Silyl Ethers Into Esters Using Acid Chlorides And Zinc Chloride
    作者:Kim,Sunggak; Lee,Won Jae
    参考文献:Synthetic Communications 日期:1986 卷标:16(6) 页码:659-65]

    65-85-0 + 60-12-8 = 94-47-3
    反应条件:1.1 Catalysts: Iron(Iii) Acetylacetonate Solvents: Xylene; Rt; 15 H,Reflux
    标题:Direct Esterification Of Carboxylic Acids With Alcohols Catalyzed By Iron(Iii) Acetylacetonate Complex
    作者:Weng,Shiue-Shien; Chen,Fong-Kuang; Ke,Chih-Shueh
    参考文献:Synthetic Communications 日期:2013 卷标:43(19) 页码:2615-2621]

    65-85-0 + 60-12-8 = 94-47-3
    反应条件:1.1 Catalysts: Oxobis(2,4-Pentanedionato-Ko2,Ko4)Titanium Solvents: Xylene; 15 H,Reflux; Reflux -> Rt1.2 Reagents: Sodium Bicarbonate Solvents: Water; Rt
    标题:Direct Atom-Efficient Esterification Between Carboxylic Acids And Alcohols Catalyzed By Amphoteric,Water-Tolerant Tio(Acac)2
    作者:Chen,Chien-Tien; Munot,Yogesh S.
    参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(21) 页码:8625-8627]

    93-58-3 + 60-12-8 = 94-47-3
    反应条件:1.1 Catalysts: Zirconium(2+),Triaquabis(η5-2,4-Cyclopentadien-1-Yl)-,1,1,2,2,3,3,4,4,5,5,6,6,...; 22 H,85 °C
    标题:Zirconocene-Catalyzed Direct (Trans)Esterification Of Acyl Acids (Esters) And Alcohols In A Strict 1 : 1 Ratio Under Solvent-Free Conditions
    作者:Tang,Zhi; Jiang,Qiutao; Peng,Lifen; Xu,Xinhua; Li,Jie; Et Al
    参考文献:Green Chemistry 日期:2017 卷标:19(22) 页码:5396-5402]

    98-88-4 + 60-12-8 = 94-47-3
    反应条件:1.1 Catalysts: Copper(4+),[1,8,15,22-Tetramethyl-29H,31H-Tetrapyrido[2,3-B:2′,3′-G:2′′,3′′-L:2... Solvents: Acetonitrile; 21 H,Reflux
    标题:Chemoselective Protocol For O-Acylation With A New Catalyst
    作者:Akhlaghinia,Batool; Safaei,Elham; Larki,Paria
    参考文献:Trends In Organic Chemistry 日期:2010 卷标:14 页码:93-106]

    65-85-0 + 60-12-8 = 94-47-3
    反应条件:1.1 Catalysts: Bis(η5-2,4-Cyclopentadien-1-Yl)Bis(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Heptadecafl...; 2.0 H,80 °C
    标题:Zirconocene Bis(Perfluorooctanesulfonate)S-Catalyzed Acylation Of Alcohols,Phenols,Thiols,And Amines Under Solvent-Free Conditions
    作者:Qiu,Renhua; Zhu,Yuyang; Xu,Xinhua; Li,Yinhui; Shao,Lingling; Et Al
    参考文献:Catalysis Communications 日期:2009 卷标:10(14) 页码:1889-1892]

    13893-90-8 + 60-12-8 = 94-47-3
    反应条件:1.1 Catalysts: Stereoisomer Of Octabutyldi-μ3-Oxobis[μ-(Thiocyanato-Kn:Kn)]Bis(Thiocyanato-Kn)T...
    标题:1,1,3,3-Tetrabutyl-1,3-Diisothiocyanatodistannoxane
    作者:Driver,Tom G.
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2009 卷标:1 页码:1-7]

    93-58-3 + 60-12-8 = 94-47-3
    反应条件:1.1 Catalysts: Iron(Iii) Acetylacetonate Solvents: Heptane; Rt -> 105 °C; 20 H,105 °C; 105 °C -> Rt1.2 Reagents: Ammonium Chloride Solvents: Water
    标题:Transesterification Catalyzed By Iron(Iii) β-Diketonate Species
    作者:Weng,Shiue-Shien; Ke,Chih-Shueh; Chen,Fong-Kuang; Lyu,You-Fu; Lin,Guan-Ying
    参考文献:Tetrahedron 日期:2011 卷标:67(9) 页码:1640-1648]

    65-85-0 = 94-47-3
    反应条件:1.1 Reagents: Diisopropylethylamine Solvents: Trihexyl(Tetradecyl)Phosphonium Bis(Trifluoromethylsulfonyl)Imide; 10 Min,75 °C1.2 12 H,75 °C
    标题:Scope And Mechanistic Insights Into The Use Of Tetradecyl(Trihexyl)Phosphonium Bistriflimide: A Remarkably Selective Ionic Liquid Solvent For Substitution Reactions
    作者:Mcnulty,James; Nair,Jerald J.; Cheekoori,Sreedhar; Larichev,Vladimir; Capretta,Alfredo; Et Al
    参考文献:Chemistry - A European Journal 日期:2006 卷标:12(36) 页码:9314-9322]

    65-85-0 = 94-47-3
    反应条件:1.1 Reagents: Diisopropylethylamine Solvents: Trihexyl(Tetradecyl)Phosphonium Bis(Trifluoromethylsulfonyl)Imide; 10 Min,30 °C1.2 12 H,75 °C
    标题:A Mild Esterification Process In Phosphonium Salt Ionic Liquid
    作者:Mcnulty,James; Cheekoori,Sreedhar; Nair,Jerald J.; Larichev,Vladimir; Capretta,Alfredo; Et Al
    参考文献:Tetrahedron Letters 日期:2005 卷标:46(21) 页码:3641-3644]

    65-85-0 + 60-12-8 = 94-47-3
    反应条件:1.1 Reagents: 4-(Dimethylamino)Pyridine Catalysts: 4,5-Dichloro-2-[(4-Nitrophenyl)Sulfonyl]-3(2H)-Pyridazinone Solvents: Tetrahydrofuran; 1 H,Reflux
    标题:An Efficient And Convenient Esterification Of Carboxylic Acids Using 4,5-Dichloro-2-[(4-Nitrophenyl)Sulfonyl]Pyridazin-3(2H)-One
    作者:Kim,Jeum-Jong; Park,Yong-Dae; Kweon,Deok-Heon; Kang,Young-Jin; Kim,Ho-Kyun; Et Al
    参考文献:Bulletin Of The Korean Chemical Society 日期:2004 卷标:25(4) 页码:501-505]

    65-85-0 + 60-12-8 = 94-47-3
    反应条件:1.1 Reagents: Sodium Nitrate,Sulfuric Acid,Permanganic Acid (Hmno4),Potassium Salt (1:1) Catalysts: Graphite (Acidic); 0 - 20 °C; 7 H,35 °C; 35 °C -> Rt1.2 Reagents: Permanganic Acid (Hmno4),Potassium Salt (1:1); Rt; 12 H,35 °C; 35 °C -> Rt1.3 Reagents: Hydrogen Peroxide Solvents: Water1.4 9 H,100 °C
    标题:Graphite Oxide-Catalyzed Esterification And Transesterification
    作者:Qi,Junmei; Xu,Yuelong; Ma,Ning; Sun,Feifei
    参考文献:Youji Huaxue 日期:2013 卷标:33(8) 页码:1839-1846]

    65-85-0 + 60-12-8 = 94-47-3
    反应条件:1.1 Catalysts: Methanesulfonic Acid,Phosphinic Acid Solvents: Water; 1 H,140 °C; 1 H,150 °C; 1 H,160 °C; 1 H,170 °C; 1 H,180 °C
    标题:Compositions Containing Phenethyl Aryl Esters As Solubilizing Agents For Active Organic Compounds
    参考文献:United States
📜二苯甲酸亚甲基酯 反应生成 苯甲酸-2-苯乙酯
参考文献:苯并三唑:新型合成助剂
标题:苯并三唑:新型合成助剂
摘要:苯并三唑和醛可逆地反应反应生成加成产物:在胺和其他nh化合物存在下,可以消除水形成bt-Chr-Nr'R''型产物.后者是用于制备伯胺,仲胺和叔胺以及羟胺,肼,酰胺,硫酰胺和磺酰胺烷基化的通用中间体.也可以制备多官能胺和其他多官能化合物,它们使曼尼希反应显着扩展.
DOI:10.1016/s0040-4020(01)87080-0

海关参考信息

专利信息


专利号:US-7022691-B2
优先权日:2002-04-04
标题 :Inhibitors of serine and metallo-β-lactamases
发明人：BUYNAK JOHN D; CHEN HANSONG
权利人:BUYNAK JOHN D; CHEN HANSONG
摘要:Compounds of formula (I): n nwherein R 1 , R 2 , R 3 , R 4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting simultaneously serine and metallo-β-lactamase enzymes, for enhancing the activity of β-lactam antibiotics, and for treating β-lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula I, and novel intermediates useful for the synthesis of compounds of formula I.

专利号:US-4348264-A
优先权日:1980-05-14
标 题 :Photocatalyzed process for producing carbapenams and carbapen-2-ems
发明人：ROSATI ROBERT L
权利人:PFIZER
摘要:Carbapenam-3-carboxylic acids and carbapen-2-em-3-carboxylic acids substituted at the 1-position with an oxo, a hydroxy or an acetoxy group, variously substituted at the 2-position with such groups as methyl, acetoxymethyl, methanesulfonyloxy, alkoxy, alkylthio, aminoalkylthio or amidinoalkylthio and optionally substituted at the 6-position with a hydroxyalkyl group, an acetoxyalkyl group or a conventional penicillin side-chain, pharmaceutically-acceptable salts thereof and various esters thereof wherein the esterifying group is selectively removed in the laboratory, or hydrolyzed under physiological conditions. n These compounds are useful either systemically or topically in the treatment of diseases caused by susceptible microorganisms, as animal feed additives for promotion of growth, or in the preservation of biodegradable materials, or as intermediates to compounds having such antibacterial activity. n Key to the synthesis of these compounds is the light catalyzed rearrangement of 2-diazo-1-oxoceph-3-em-4-carboxylates to 1-oxocarbapen-2-em-3-carboxylates, a newly discovered reaction determined to be of general applicability.

专利号:US-4429128-A
优先权日:1981-02-09
标题 :Carbapenams and carbapen-2-ems and process therefor
发明人：ROSATI ROBERT L
权利人:PFIZER
摘要:Carbapenam-3-carboxylic acids and carbapen-2-em-3-carboxylic acids substituted at the 1-position with an oxo, a hydroxy or an acetoxy group, variously substituted at the 2-position with such groups as methyl, acetoxymethyl, methanesulfonyloxy, alkoxy, alkylthio, aminoalkylthio or amidinoalkylthio and optionally substituted at the 6-position with a hydroxyalkyl group, an acetoxyalkyl group or a conventional penicillin side-chain, pharmaceutically-acceptable salts thereof and various esters thereof wherein the esterifying group is selectively removed in the laboratory, or hydrolyzed under physiological conditions. n These compounds are useful either systemically or topically in the treatment of diseases caused by susceptible microorganisms, as animal feed additives for promotion of growth, or in the preservation of biodegradable materials, or as intermediates to compounds having such antibacterial activity. n Key to the synthesis of these compounds is the light catalyzed rearrangement of 2-diazo-1-oxoceph-3-em-4-carboxylates to 1-oxocarbapen-2-em-3-carboxylates, a newly discovered reaction determined to be of general applicability.

专利号:RU-2064931-C1
优先权日:1993-06-18
标题:Method of synthesis of penicillanic acid 1,1-dioxide and its salt

专利号:RU-2064932-C1
优先权日:1993-06-18
标题:Method of synthesis of 6,6-dibromopenicillanic acid

专利号:JP-S6117586-A
优先权日:1984-04-06
标题:Intermediates useful in the synthesis of carbapenems and penem antibiotics and methods for their production

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合成参考文献


摘要:Food and Cosmetics Toxicology., 13(905), 1975
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