CAS: 927-58-2; 4-Bromobutyryl Chloride

该化合物是有机合成中使用的一种多用途乙酰剂,特别是用于引入4-溴丁基苯乙烯,它与核素的高度反应性能够有效制备酯,氨化物和其他衍生物.溴替代物可以进一步实现功能化,在制药和精细化学应用中具有价值.由于腐蚀性和湿度敏感性,谨慎地处理.

英文名称4-Bromobutyryl Chloride
中文名称4-溴丁酰氯
IUPAC名称4-bromobutanoyl chloride
其它别名4-Bromobutanoic acid chloride; 4-Bromobutanoyl chloride; 4-Bromobutyroylic chloride
CAS编号927-58-2
MFCD编号:MFCD00000753
EINECS号:213-154-0
FDA UNII编号:898F737ARM
分子式:C4H6BrClO
分子量:185.45
产品CID: 1966022
产品分类化学试剂 → 有机试剂 → 酰卤

相似结构搜索
InChIKey: LRTRXDSAJLSRTG-UHFFFAOYSA-N
InChI=1S/C4H6BrClO/c5-3-1-2-4(6)7/h1-3H2…
计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数3.0

物理性质

沸点101 °C37 mm Hg(文献)
闪点91 °C
密度1.60 g/mL at 20 °C
PSA:17.07
LogP:1.9269
折射率n 20/D 1.492(文献)
蒸汽压0.483 mmHg at 25 °C
溶解性Miscible With Organic Solvents. Immiscible With Water.
敏感性易受潮
外观形态透明无色至微黄色或淡粉红色液体
储存条件惰性气氛,室温
产品应用该化合物用于合成氨酸的前体.

MSDS等安全信息

GHS象形图
GHS符号GHS07 & GHS05;
注释: Exclamation mark & Corrosion
危险类别金属腐蚀物类别1
皮肤腐蚀类别1B
严重眼损伤类别1
特定目标器官毒性 - 单次接触类别3
警示词Danger(危险)
危险描述H290 |可能对金属造成腐蚀.
H314 |造成严重皮肤灼伤和眼损伤.
H318 |造成严重眼损伤.
H335 |可能引起呼吸道刺激.
防范说明P261-P271-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
危险等级8
UN编号UN 3265 8/PG 2
危险品标志C
包装等级II
安全声明26-36/37/39-45
危险类别码14-34-37
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

bromobutyric acid 4-Brombuttersaeure-trimethylsilylester Ethyl 4-bromobutyrate 4-bromo-N-(4-chlorophenyl)butyramide 4-bromobutanoic acid N-phenylamide 4-bromo-1-phenyl-1-butanone

合成工艺路线路线简述

合成目标产物 4-Bromobutyryl Chloride 主要起始原料 4-Bromobutyric Acid
2623-87-2 = 927-58-2
反应条件:1.1 Reagents: Oxalyl Chloride; 4 H,Rt
标题:Wide Thermal Range,Exclusive Occurrence Of Technically Significant Chiral Nematic Phase: Synthesis And Mesomorphism Of Cholesterol-Based Non-Symmetric Dimers
作者:Nayak,Rashmi Ashwathama; Bhat,Sachin A.; Rao,D. S. Shankar; Yelamaggad,C. V.
参考文献:Bulletin Of Materials Science 日期:2020 卷标:43(1)]

2623-87-2 = 927-58-2
反应条件:1.1 Reagents: Thionyl Chloride Catalysts: Dimethylformamide Solvents: Dichloromethane; 0 °C; 4 H,Rt
标题:Bifunctional Heterocycles,Their Use In Targeted Degradation Of Rapidly Accelerated Fibrosarcoma Polypeptides And Their Preparation
参考文献:United States]

2623-87-2 = 927-58-2
反应条件:1.1 Reagents: Thionyl Chloride Catalysts: Dimethylformamide Solvents: Dichloromethane; 4 H,Rt
标题:Polycyclic Compounds And Methods For The Targeted Degradation Of Rapidly Accelerated Fibrosarcoma Polypeptides
参考文献:World Intellectual Property Organization]

2623-87-2 = 927-58-2
反应条件:1.1 Reagents: Oxalyl Chloride Solvents: Chloroform,Dimethylformamide; Rt; Overnight,Rt
标题:Light Emitter For A Display
参考文献:United States]

= 927-58-2
反应条件:1.1 Reagents: Hydrogen Bromide Solvents: Acetic Acid; 2 H,Rt; 2 H,70 °C1.2 Reagents: Thionyl Chloride; 3 H,Reflux
标题:A New One-Pot Synthetic Method For Selenium-Containing Medium-Sized α,β-Unsaturated Cyclic Ketones
作者:Sashida,Haruki; Nakayama,Akemi; Kaname,Mamoru
参考文献:Synthesis 日期:2008 卷标:(20) 页码:3229-3236]

= 927-58-2
反应条件:1.1 Reagents: Hydrogen Bromide Solvents: Acetic Acid; 2 H,25 °C; 2 H,70 °C1.2 Reagents: Thionyl Chloride; 3 H,Reflux
标题:Alternating Copolymerization Of γ-Selenobutyrolactone With Episulfides For High Refractive Index Selenium-Containing Polythioesters
作者:Zhang,Cheng-Jian; Hu,Lan-Fang; Yang,Jia-Liang; Cao,Xiao-Han; Zhang,Xing-Hong
参考文献:European Polymer Journal 日期:2020 卷标:133]

= 927-58-2
反应条件:1.1 Reagents: Hydrogen Bromide Solvents: Acetic Acid; 2 H,25 °C; 2 H,70 °C1.2 Reagents: Thionyl Chloride; 3 H,Reflux
标题:Metal-Free Alternating Copolymerization Of Nonstrained γ-Selenobutyrolactone With Epoxides For Selenium-Rich Polyesters
作者:Zhang,Cheng-Jian; Cao,Xiao-Han; Zhang,Xing-Hong
参考文献:Macromolecules (Washington 日期:2020 卷标:53(1) 页码:203-211]

2623-87-2 = 927-58-2
反应条件:1.1 Reagents: Thionyl Chloride; Overnight,Rt
标题:Multiple Nematic Phases Observed In Chiral Mesogenic Dimers
作者:Zep,Anna; Aya,Satoshi; Aihara,Kenji; Ema,Kenji; Pociecha,Damian; Et Al
参考文献:Journal Of Materials Chemistry C: Materials For Optical And Electronic Devices 日期:2013 卷标:1(1) 页码:46-49]

2623-87-2 = 927-58-2
反应条件:1.1 Reagents: Oxalyl Chloride Catalysts: Dimethylformamide Solvents: Dichloromethane; 0 °C; 2 H,Rt
标题:Remote C-H Pyridylation Of Hydroxamates Through Direct Photoexcitation Of O-Aryl Oxime Pyridinium Intermediates
作者:Kweon,Byeongseok; Kim,Changha; Kim,Seonyul; Hong,Sungwoo
参考文献:Angewandte Chemie 日期:2021 卷标:60(51) 页码:26813-26821]

2623-87-2 = 927-58-2
反应条件:1.1 Catalysts: Dimethylformamide Solvents: Dichloromethane; -5 - 5 °C1.2 Reagents: Thionyl Chloride; -5 - 5 °C; 5 °C -> Rt; 4 H,Rt
标题:Preparation Of Highly Expressed Cationic Lipid Compounds And Its Applications
参考文献:China]

2623-87-2 = 927-58-2
反应条件:1.1 Catalysts: Dimethylformamide Solvents: Chloroform; Overnight,Rt
标题:Light Emitting Polymers Produced By Photopolymerization Of Reactive Mesogens
参考文献:United States]

2623-87-2 = 927-58-2
反应条件:1.1 Reagents: Oxalyl Chloride Catalysts: Dimethylformamide Solvents: Chloroform; Rt; Overnight,Rt
标题:Liquid Crystal Alignment Layer,Display,Reactive Mesogens And Polymers Formed From The Reactive Mesogen
参考文献:United States]

2623-87-2 = 927-58-2
反应条件:1.1 Reagents: Oxalyl Chloride Catalysts: Dimethylformamide Solvents: Chloroform; Rt; Overnight,Rt
标题:Photopolymerization Of Light Emitting Polymer For Electronic Displays
参考文献:United States]

2623-87-2 = 927-58-2
反应条件:1.1 Reagents: Thionyl Chloride
标题:Synthesis Of The Triethyl Esters Of 1-Halobutane-1,4,4-Tricarboxylic Acids
作者:Incze,M.; Soti,F.; Szantay,C.
参考文献:Acta Chimica Academiae Scientiarum Hungaricae 日期:1980 卷标:104(3) 页码:267-71]

2623-87-2 = 927-58-2
反应条件:1.1 Reagents: Thionyl Chloride; Overnight,Rt
标题:A Twist-Bend Nematic (Ntb) Phase Of Chiral Materials
作者:Gorecka,Ewa; Vaupotic,Natasa; Zep,Anna; Pociecha,Damian; Yoshioka,Jun; Et Al
参考文献:Angewandte Chemie 日期:2015 卷标:54(35) 页码:10155-10159]

2623-87-2 = 927-58-2
反应条件:1.1 Reagents: Thionyl Chloride Catalysts: Dimethylformamide Solvents: Dichloromethane; 1 H,23 °C
标题:Preparation Of Ionizable Amphiphilic Janus Dendrimers As Uses Thereof
参考文献:World Intellectual Property Organization]

2623-87-2 = 927-58-2
反应条件:1.1 Reagents: Oxalyl Chloride Catalysts: Dimethylformamide Solvents: Dichloromethane; 0 °C; 2 H,0 °C
标题:Intramolecular Dehydrogenative Amination Of Alkenes Via Dual Organic Photoredox And Cobalt Catalysis Without A Hydrogen Acceptor
作者:Yu,Wan-Lei; Ren,Zi-Gang; Ma,Wei; Zheng,Haixue; Wu,Wangsuo; Et Al
参考文献:Green Chemistry 日期:2022 卷标:24(16) 页码:6131-6137]

2623-87-2 = 927-58-2
反应条件:1.1 Reagents: Thionyl Chloride Catalysts: Dimethylformamide Solvents: Dichloromethane; 1 H,23 °C
标题:The Unexpected Importance Of The Primary Structure Of The Hydrophobic Part Of One-Component Ionizable Amphiphilic Janus Dendrimers In Targeted Mrna Delivery Activity
作者:Zhang,Dapeng; Atochina-Vasserman,Elena N.; Lu,Juncheng; Maurya,Devendra S.; Xiao,Qi; Et Al
参考文献:Journal Of The American Chemical Society 日期:2022 卷标:144(11) 页码:4746-4753]

2623-87-2 = 927-58-2
反应条件:1.1 Reagents: Thionyl Chloride Catalysts: Dimethylformamide Solvents: Dichloromethane; 1 H,23 °C
标题:Targeted Delivery Of Mrna With One-Component Ionizable Amphiphilic Janus Dendrimers
作者:Zhang,Dapeng; Atochina-Vasserman,Elena N.; Maurya,Devendra S.; Liu,Matthew; Xiao,Qi; Et Al
参考文献:Journal Of The American Chemical Society 日期:2021 卷标:143(43) 页码:17975-17982

4-溴丁酸置于氯化亚砜体系中,用二氯甲烷,N,N-二甲基甲酰胺作为反应溶剂,化学反应生成 4-溴丁酰氯
参考文献:使用基于季戊四醇的单组分可电离两亲性 Janus 树枝状聚合物将 Mrna 靶向且均匀分布地递送至器官
标题:使用基于季戊四醇的单组分可电离两亲性 Janus 树枝状聚合物将 Mrna 靶向且均匀分布地递送至器官
摘要:用病毒和合成载体输送核酸开创了遗传纳米医学的先河.四组分脂质纳米粒子 (Lnp) 由可电离脂质,磷脂,胆固醇和 Peg 缀合脂质组成,通过微流体或 T 管组装,是用于递送 Mrna 的基准合成载体.我们开发了一种用于 Mrna 的单组分多功能序列定义电离两亲性 Janus Dendrimer (Iajd) 递送系统,以补充 Lnp.iajd 由多功能亲水性低代树突或与疏水性树突缀合的小树突组成.他们的灵感来自于两亲性 Janus 树枝状聚合物和糖树枝状聚合物.iajd 通过简单地注射到醋酸盐缓冲液中,而不是通过 Lnp 所需的复杂技术,与 Mrna 共同组装成可预测大小的囊泡,称为树状聚合物纳米颗粒 (Dnp).通过简单注射组装 Dnp 以及 Iajd 亲水和疏水模块中的序列设计,可以快速筛选以实现发现.当 Iajd 的分支点由通过季戊四醇 (Pe) 连接的对称和非对称取代的植物酚酸构建时
DOI:10.1021/jacs.3C07337

海关参考信息

2912110000-甲醛
2912120000-乙醛
2903110000-一氯甲烷及氯乙烷
2903399020-溴甲烷
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-5578500-A
优先权日:1991-07-31
标题 :Reagents and methods for the quantification of imipramine or desipramine in biological fluids
发明人：ADAMCZYK MACIEJ; HARRINGTON CHARLES A; JOHNSON DONALD
权利人:ABBOTT LAB
摘要:Immunoassay methods and reagents for the specific quantification of imipramine or desipramine in a test sample are disclosed. The measurement of imipramine or desipramine is accomplished in a specific immunoassay employing antibodies prepared with imipramine or desipramine derivatives of the Formula III: ##STR1## wherein P is an immunogenic carrier material, X is two heteroatoms, Y is a linking group comprising from 1 to 6 carbon atoms and P is an immunogenic carrier material, and wherein for imipramine, R is CH 3 , and for desipramine, R is H. n The present invention also describes the synthesis of unique labeled reagents of the structure of the Formula IV: ##STR2## wherein Z is a linking group comprising 1 to 4 carbon atoms and 0 to 2 heteroatoms and Q is a detectable moiety, preferably fluorescein or a fluorescein derivative, and wherein for imipramine, R 1 is CH 3 , and for desipramine, R 1 is H.

专利号:US-6627744-B2
优先权日:1999-07-02
标题 :Synthesis of glycodendrimer reagents
发明人：DAVIS BENJAMIN G; JONES JOHN BRYAN; BOTT RICHARD R
权利人:GENENCOR INT
摘要:The present invention relates to a chemically modified mutant protein including a cysteine residue substituted for a residue other than cysteine n a precursor protein, the substituted cysteine residue being subsequently modified by reacting the cysteine residue with a glycosylated thiosulfonate. Also a method of producing the chemically modified mutant protein is provided. The present invention also relates to a glycosylated methanethiosulfonate. Another aspect of the present invention is a method of modifying the functional characteristics of a protein including providing a protein and reacting the protein with a glycosylated methanethiosulfonate reagent under conditions effective to produce a glycoprotein with altered functional characteristics as compared to the protein. In addition, the present invention relates to methods of determining the structure-function relationships of chemically modified mutant proteins. The present invention also relates to synthetic methods for producing thio-glycoses, the thio-glycoses so produced, and to methods for producing glycodendrimer reagents.

专利号:US-8137582-B2
优先权日:2007-08-15
标题 :Alkaloid monomers, liquid crystal compositions and polymer networks derived therefrom
发明人：GOLDFINGER MARC B; QI KAI
权利人:GOLDFINGER MARC B; QI KAI; DU PONT
摘要:Disclosed is the chemical synthesis of chiral alkaloid monomers, liquid crystal compositions comprising the chiral alkaloid monomers, and polymerization of the liquid crystal compositions to provide polymer networks with useful cholesteric optical properties and stability.

专利号:US-6369246-B2
优先权日:1999-04-14
标题 :Synthesis and pharmaceuticals of novel 9-substituted-1, 5-dichloroanthracene analogs
发明人：HUANG HSU-SHAN; LEE KUNG-YUAN; SHI CHANG-HSIN; HSU HSIEN-CHIN
权利人:KEITH CHAN GLOBOASIA LLC DR
摘要:The invention relates to novel anthracene compounds useful in the treatment of allergic, inflammatory conditions, tumor conditions and therapeutic compositions containing such compounds. The compounds of the present invention are 9-acyloxy-substituted 1,5-dichloroanthracene or analogs thereof. According to the practice of the invention, there are provided 9-acyloxy substituted 1,5-dichloroanthracene compounds according to formula III:wherein R represents a straight or branched chain alkyl group having 1 to 6 carbons which may be substituted with one or more groups of R1, or R represents phenyl or benzyl which may be substituted with one or two groups of R2; wherein R1 is selected from the group consisting of halogen, -NO2, -OCH3, OCH2CH3, and -OCH2CH2CH3; and wherein R2 is selected from the group consisting of a straight or branched chain alkyl group having 1 to 4 carbons, halogen, -NO2, -OCH3, -OCH2CH3, and -OCH2CH2CH3.

专利号:CN-102010320-A
优先权日:2010-11-18
标题 :A solvent-free one-pot synthesis of 4-bromobutyryl chloride and 5-bromovaleryl chloride

专利号:EP-1384710-B1
优先权日:1995-11-27
标题 :Synthesis of heterocyclic compounds containing five- or six-membered rings

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📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献

参考文献:10.1007/7081_2019_35
摘要:Josse S, Postel D. Cyanohydrins and Aminocyanides as Key Intermediates to Various Spiroheterocyclic Sugars. 2019. In: Topics in Heterocyclic Chemistry.
参考文献:10.1055/s-0029-1218684
摘要:Albrecht M, Baumert M, Winkler H, Schalley C. Tuning the Polarity of Hierarchically Assembled Helicates. Synthesis. 2010 Feb 24;2010(06):953–8. doi: 10.1055/s-0029-1218684.
参考文献:10.1007/s13233-024-00325-y
摘要:Ko S, Lee J, Park D, Kim K. Antimicrobial polymer coatings on surfaces: preparation and activity. Macromol. Res. 2024 Sep 12;33(2):137–51. doi: 10.1007/s13233-024-00325-y.