CAS: 77324-87-9; Methyl 2-Methyl-5-Nitrobenzoate

上下游产品

methanol 2-methyl-5-nitrobenzamide 2-Methyl-benzoic acid methyl ester diazomethanetrans-stilbene-carboxylic acid-(2)4-nitro-trans-stilbene-carboxylic acid-(2) methyl 2-methyl-3,5-dinitrobenzoate methyl 5-amino-2-methylbenzoate 4-nitro-phthalic acid-2-methyl ester

📜对甲苯甲酸置于硫酸,硝酸体系中,化学反应生成 2-甲基-5-硝基苯甲酸甲酯
参考文献:含co(II)槲皮素2,3-双加氧酶的es(酶-底物)复合物的结构和功能模型系列
标题:含co(II)槲皮素2,3-双加氧酶的es(酶-底物)复合物的结构和功能模型系列
摘要:一系列的单核的co Ii-Flavonolate络合物[co Ii大号-[r(fla)](大号ř ħ = 2-{[双(吡啶-2-基甲基)氨基]甲基}-P /米-R-苯甲酸; R = P-Ome(1),P-Me(2),M-Br(4)和m-No 2(5); Fla =黄酮酸酯)被设计并合成为es(酶-底物)复合物的结构和功能模型,以模拟含co(II)的槲皮素2,3-二加氧酶(co-2,3-Qd)的活性位点.每个络合物中的金属中心co(II)离子显示出相似的扭曲八面体几何形状.模型复合物在低温下显示出高的酶型双加氧反应性(配位底物黄酮酸酯的氧化o-杂环开环),这可能是由于配体中的羧酸酯基团所致.反应性表现出依赖于取代基的顺序-Ome(1)>-Me(2)>-H(3)14B>-Br(4)>-No 2(5),而hammett图是线性的(ρ= −0.78).这可以解释为配体
DOI:10.1021/ic402695C

专利信息

专利号:US-2009215742-A1
优先权日:2005-05-03
标 题:Amide resorcinol compounds
发明人：FUNK LEE ANDREW; JOHNSON MARY CATHERINE; KUNG PEI-PEI; ZHOU ZHONGXIANG
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), n n n n n n n n n n and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as HSP-90 inhibitors.

专利号:CN-118619834-A
优先权日:2023-03-09
标 题:Continuous flow nitration synthesis method of methyl o-methylbenzoate in microchannel reactor