CAS: 7057-27-4; 3'-Deoxyuridine

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📜尿嘧啶核苷置于吡啶,4-二甲氨基吡啶,偶氮二异丁腈,四丁基氟化铵,三正丁基氢锡,Silver Nitrate,溶剂黄146体系中,用 四氢呋喃,甲苯,乙腈 作为反应溶剂,化学反应 146.0H,反应生成 3-脱氧尿苷
参考文献:各种3'-脱氧嘧啶核苷类似物的合成和抗癌活性以及1-(3-脱氧-β-D-苏-戊呋喃糖基)胞嘧啶的晶体结构.
标题:各种3'-脱氧嘧啶核苷类似物的合成和抗癌活性以及1-(3-脱氧-β-D-苏-戊呋喃糖基)胞嘧啶的晶体结构.
摘要:已经合成了多种3'-脱氧嘧啶核苷类似物,以评估其作为潜在的抗癌和抗病毒剂.在这些化合物中,1-(3-脱氧-β-D-苏-戊呋喃糖基)胞嘧啶(10,3'-脱氧-Ara-C)和3'-脱氧胞苷(22)对ccrf-Cem具有显着的抗癌活性,L1210,P388和s-180癌细胞系在体外产生的3'-Deoxy-Ara-C Ed50值分别为2,10,5和34 Microm(10);对于3'-脱氧胞苷(22),分别为25,5,2.5和15 Microm.因此,对于ccrf-Cem细胞,3'-脱氧-Ara-C(10)的活性是3'-脱氧胞苷(22)的12.5倍.证明了3'-脱氧-Ara-C(10)的2'-O-乙酰基,5'-O-乙酰基和2',5'-二-O-乙酰基衍生物,化合物34,31和30抗癌活性与3'相同-针对ccrf-Cem,L1210,P388和s-180细胞的-Deoxy-Ara-C(10).5'
DOI:10.1021/jm00106A034

专利信息

专利号:US-11858953-B2
优先权日:2018-04-04
标 题:Compositions and methods for synthesis of phosphorylated molecules
发明人：CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT
权利人:UNIV CALIFORNIA
摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

专利号:US-4900828-A
优先权日:1988-05-12
标 题:Intermediate compounds and an improved procedure for the synthesis of 2',3'-dideoxycytidine
发明人：BELICA PETER S; HUANG TAI-NANG; MANCHAND PERCY S; PARTRIDGE JOHN J; TAM STEVE
权利人:HOFFMANN LA ROCHE
摘要:A method for the synthesis of 2',3'-dideoxycytidine comprising a novel procedure of bromoacetylating cytidine to yield novel intermediates which are subsequently reduced and hydrogenated by novel procedures to yield 2',3'-dideoxycytidine.

专利号:US-2020239500-A1
优先权日:2018-04-04
标 题 :Compositions and Methods for Synthesis of Phosphorylated Molecules

专利号:US-2024002331-A1
优先权日:2022-06-08
标 题 :Ionizable cationic lipids and lipid nanoparticles, and methods of synthesis and use thereof
发明人：ALI MIR; BOESCH AUSTIN WAYNE; DRUMMOND DARYL CLARK; KUHLMAN WILLIAM; NIELSEN ULRIK
权利人:TIDAL THERAPEUTICS INC
摘要:Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.

专利号:US-9738678-B2
优先权日:2007-07-09
标 题 :Substituted nucleoside derivatives with antiviral and antimicrobial properties
发明人：DONCEL GUSTAVO F; PARANG KEYKAVOUS; AGARWAL HITESH KUMAR
权利人:EASTERN VIRGINIA MEDICAL SCHOOL; BOARD OF GOVERNORS FOR HIGHER EDUCATION STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS
摘要:The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on multivalent scaffolds (e.g., polymers, peptides, polycarboxylic acid substituted compounds, compounds containing polycycloSaligenyl groups) that display potent anti-HIV activity. Furthermore, they show enhanced activity against multi-drug resistant, R5, and cell-associated virus. Some of them also display activity against other sexually transmitted pathogens and sperm. The present invention provides their methods of synthesis, composition of matter, and methods of use. Emphasis is placed on their application as topical microbicides to treat or prevent sexual transmission of disease, especially HIV/AIDS.

专利号:US-2025205169-A1
优先权日:2023-12-13
标 题:Ionizable cationic lipids and lipid nanoparticles, and methods of synthesis and use thereof
发明人：ALI MIR
权利人:TIDAL THERAPEUTICS INC
摘要:Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.