CAS: 631-89-0; (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-Trimethylcyclohex-1-En-1-yl)Nona-2,4,6,8-Tetraen-1-Yl (9Z,12Z)-Octadeca-9,12-Dienoate

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维生素 A 醋酸酯 Retinol Acetate 127-47-9

📜(Z,Z)-9,12-十八烷二烯酸二聚物,维生素 A 醋酸酯置于novozyme 435体系中,用 甲苯 作为反应溶剂,化学反应 20.0H,反应生成 视黄醇亚油酸酯
参考文献:An Lc/ms/ms Method For Stable Isotope Dilution Studies Of β-Carotene Bioavailability,Bioconversion,And Vitamin A Status In Humans
标题:An Lc/ms/ms Method For Stable Isotope Dilution Studies Of β-Carotene Bioavailability,Bioconversion,And Vitamin A Status In Humans
摘要:Isotope Dilution Is Currently The Most Accurate Technique In Humans To Determine Vitamin A Status And Bioavailability/bioconversion Of Provitamin A Carotenoids Such As Beta-Carotene. However,Limits Of Ms Detection,Coupled With Extensive Isolation Procedures,Have Hindered Investigations Of Physiologically-Relevant Doses Of Stable Isotopes In Large Intervention Trials. Here,A Sensitive Liquid Chromatography-Tandem Mass Spectrometry (Lc/ms/ms) Analytical Method Was Developed To Study The Plasma Response From Coadministered Oral Doses Of 2 Mg [c-13(10)]Beta-Carotene And 1 Mg [c-13(10)]Retinyl Acetate In Human Subjects Over A 2 Week Period. A Reverse Phase C-18 Column And Binary Mobile Phase Solvent System Separated Beta-Carotene,Retinol,Retinyl Acetate,Retinyl Linoleate,Retinyl Palmitate/retinyl Oleate,And Retinyl Stearate Within A 7 Min Run Time. Selected Reaction Monitoring Of Analytes Was Performed Under Atmospheric Pressure Chemical Ionization In Positive Mode At M/z 537-> 321 And M/z 269-> 93 For Respective [c-12]Beta-Carotene And [c-12]Retinoids; M/z 547-> 330 And M/z 274-> 98 For [c-13(10)]Beta-Carotene And [c-13(5)] Cleavage Products; And M/z 279-> 100 For Metabolites Of [c-13(10)]Retinyl Acetate. A Single One-Phase Solvent Extraction,With No Saponification Or Purification Steps,Left Retinyl Esters Intact For Determination Of Intestinally-Derived Retinol In Chylomicrons Versus Retinol From The Liver Bound To Retinol Binding Protein. Coadministration Of [c-13(10)]Retinyl Acetate With [c-13(10)]Beta-Carotene Not Only Acts As A Reference Dose For Inter-Individual Variations In Absorption And Chylomicron Clearance Rates,But Also Allows For Simultaneous Determination Of An Individual'S Vitamin A Status.
DOI:10.1194/jlr.D040204

专利信息

专利号:US-2008081082-A1
优先权日:2000-11-21
标题:Topical Skin Compositions, Their Preparation, and Their Use
发明人：ZIMMERMAN AMY C; DEPPA DEBRA J; O'TOOLE DEBORAH A; MAYNE JAMES R
权利人:ACCESS BUSINES GROUP INTERNAT
摘要:Topical skin compositions include a complex containing components to provide a defense against the various pathway mechanisms of free radicals, reactive oxygen species, reactive nitrogen species, and other oxidizing species on the human body including the skin. The compositions may be administered by topically applying them in an amount to inhibit those mechanisms. The compositions and methods are directed to the prevention of the adverse or detrimental effects of free radicals, reactive oxygen species, reactive nitrogen species, and other oxidizing species on the human body including the skin. Thus, the compositions according to the invention improve barrier function, inhibit elastase and collagenase, and/or promote synthesis of collagen and elastin.

专利号:US-2008124409-A1
优先权日:2000-11-21
标题 :Topical Skin Compositions, Their Preparation, and Their Use
发明人：ZIMMERMAN AMY C; DEPPA DEBRA J; O'TOOLE DEBORAH A; MAYNE JAMES R
权利人:ACCESS BUSINESS GROUP INT LLC
摘要:Topical skin compositions include a complex containing components to provide a defense against the various pathway mechanisms of free radicals, reactive oxygen species, reactive nitrogen species, and other oxidizing species on the human body including the skin. The compositions may be administered by topically applying them in an amount to inhibit those mechanisms. The compositions and methods are directed to the prevention of the adverse or detrimental effects of free radicals, reactive oxygen species, reactive nitrogen species, and other oxidizing species on the human body including the skin. Thus, the compositions according to the invention improve barrier function, inhibit elastase and collagenase, and/or promote synthesis of collagen and elastin.