CAS: 60669-69-4; Dibutylboron Trifluoromethanesulfonate

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CAS号122-56-5 三丁基硼 | CAS号1493-13-6 三氟甲烷磺酸 | CAS号2403-22-7 N-丁基苄胺 | CAS号61829-43-4 N-butyl-4-metho... | CAS号6281-00-1 N-butylnaphthal... | CAS号5441-81-6 N-butyl-4-chlor...

📜三丁基硼,三氟甲磺酸 反应生成 三氟甲磺酸二丁硼
参考文献:对甲氧基亚苄基乙缩醛的还原裂解中的温度控制区域选择性.
标题:对甲氧基亚苄基乙缩醛的还原裂解中的温度控制区域选择性.
摘要:可以通过调节反应温度和试剂浓度来调节吡咯型4,6-对-甲氧基亚苄基乙缩醛与bh 3 / Bu 2 Botf在thf中的区域选择性开环.在0还原裂解oc下导致的专属形成4-ø-P甲氧基苄基(pmb)醚,而反应在-78oc下产生的6-ö-Pmb醚以高收率.观测到后一种条件与包括烯丙基醚和烯醇醚在内的各种酸敏感性官能团相容.水的存在不会干扰还原性开环,并且可能有助于原位反应生成h +作为6-O的催化剂-Pmb醚的形成.在严格非质子条件下的还原裂解被大大减速,并且仅产生4-O-Pmb醚.4,6-乙缩醛的温度依赖性还原裂解可通过动力学与热力学控制来在较高温度下,更易接近的o-6的路易斯酸配位是有利的,而更碱性但空间受限的质子化o-4在低温下占主导地位.
DOI:10.1021/jo048999M

专利信息

专利号:US-2004018598-A1
优先权日:2000-05-30
标题 :Bio-intermediates for use in the chemical synthesis of polyketides
发明人：SANTI DANIEL; ASHLEY GARY; MYLES DAVID C
摘要:The present invention relates to compounds made by a subset of modules from one or more polyketide synthase (“PKSâ€?) genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring polyketides or derivatives thereof. The biologically derived intermediates (“bio-intermediatesâ€?) generally represent particularly difficult compounds to synthesize using traditional chemical approaches due to one or more stereocenters. In one aspect of the invention, an intermediate in the synthesis of epothilone is provided that feeds into the synthetic protocol of Danishefsky and co-workers. In another aspect of the invention, intermediates in the synthesis of discodermolide are provided that feed into the synthetic protocol of Smith and co-workers. By taking advantage of the inherent stereochemical specificity of biological processes, the syntheses of key intermediates and thus the overall syntheses of compounds like epothilone and discodermolide are greaty simplified.

专利号:US-5973161-A
优先权日:1996-03-18
标 题:Enantioselective synthesis of cyclopentenes
发明人：CRIMMINS MICHAEL T
权利人:UNIV NORTH CAROLINA
摘要:Methods of synthesizing compounds of the Formula V: ##STR1## wherein X c is a chiral auxiliary, m is from 1 to 4, and R 8 is hydrogen or --OH, are provided. n Additionally, methods of synthesizing compounds of the Formula XII: ##STR2## wherein m is from 1-4; B is hydrogen or a blocking group; and R 13 is a leaving group or a compound of formula R 14 --N--R 15 ; n wherein R 14 is hydrogen or branched or straight-chain C1-C6 alkyl; and R 15 is hydrogen, C3-C8 cycloalkyl, or branched or straight-chain alkyl; n are also provided. Novel compounds useful in the synthesis of cyclopentenes and carbocyclic nucleosides are further provided.

专利号:US-5446158-A
优先权日:1989-01-11
标题:Process for synthesis of FK-506 and tricarbonyl intermediates
发明人：JONES TODD K; MILLS SANDER G; ASKIN DAVID; REAMER ROBERT A; DESMOND RICHARD; TSCHAEN DAVID M; VOLANTE RALPH P; SHINKAI ICHIRO
权利人:MERCK & CO INC
摘要:A process is described for the total synthesis of the macrolide immunosuppressant, FK-506, and important tricarbonyl process intermediates thereof. The tricarbonyl intermediates can be produced by the mild oxidation of 2,3-dihydroxy carboxylate compounds containing olefin moieties.

专利号:US-7183059-B2
优先权日:1998-03-23
标 题 :Synthesis of compounds and libraries of compounds
发明人：VERDINE GREGORY L; CHYTIL MILAN; DIDIUK MARY T; MALINKY TIFFANY
权利人:HARVARD COLLEGE
摘要:A method of generating a compound having at least one biological activity of a peptide. The method includes identifying a biologically active peptide, providing a first monomer which contains terminal reactive moieties and at least one functionalizable group, providing a second monomer which contains terminal reactive moieties and at least one functionalizable group, and reacting first and second monomer under stereo-and/or regiochemically controlled conditions to yield a compound in which the monomers are attached by way of terminal reactive moieties.

专利号:US-5132457-A
优先权日:1991-08-26
标 题 :Stereospecific synthesis of 2(R)-2-methyl-3-dimethylamino-propiophenone (d-DAMP)
发明人：MATHEW JACOB
权利人:MALLINCKRODT SPEC CHEM
摘要:In a method for producing 2(R)-2-methyl-3-dimethylamino-propiophenone (d-DAMP), a chiral ester of the formula ##STR1## wherein R is an alkyl of from 1 to about 5 carbon atoms, is provided. The chiral easter of formula (I) is converted into a chiral amino-alcohol of the formula ##STR2## and the chiral amino-alcohol is oxidized so as to form d-DAMP.

专利号:US-11530204-B2
优先权日:2019-09-30
标 题 :Biocatalytic synthesis of cryptophycin anticancer agents
发明人：SHERMAN DAVID H; SCHMIDT JENNIFER J
权利人:UNIV MICHIGAN REGENTS
摘要:The disclosure provides cryptophycin intermediates, cryptophycin analogs, and cryptophycin chimeric molecules useful in treating cancer, as well as methods of producing these compounds and methods of treating cancer.