CAS: 58378-33-9; 1-(Dimethoxymethyl)-2-Methoxybenzene

相似化合物

2186-92-7 606-45-1 81245-24-1

上下游产品

ortho-anisaldehyde trimethyl orthoformate methanol salicylaldehyde (2R*,4S*)-4-chloro-2-(2-methoxyphenyl)tetrahydro-2H-pyran meso-1,2-bis-(2'-methoxyphenyl)-1,2-dimethoxyethane d,l-1,2-bis-(2'-methoxyphenyl)-1,2-dimethoxyethane [Methoxy-(2-methoxy-phenyl)-methyl]-phosphonic acid diethyl ester

📜邻甲氧基苯甲醛,原甲酸三甲酯置于camphorsulfonic Acid体系中,用 甲醇 作为反应溶剂,化学反应 60.0H,以98%的收率获得产物2-甲氧基苯甲醛缩二甲醇
参考文献:三乙基和三苯基膦盐与二甲基缩醛反应中的二分反应性:α-烷氧基官能化叶立德的新入口和乙烯基醚和烷氧基二烯的一般合成
标题:三乙基和三苯基膦盐与二甲基缩醛反应中的二分反应性:α-烷氧基官能化叶立德的新入口和乙烯基醚和烷氧基二烯的一般合成
摘要:三烷基与三苯基膦 Hbr 盐与缩醛反应中二分反应性的发现允许进入官能化的 α-甲氧基鏻盐和叔膦甲基化的新方法.新协议打开了合成乙烯基醚和差异取代的 1,3-二烯的通用入口,通过来自 α-甲氧基鏻盐的官能化叶立德的 Wittig 反应.
DOI:10.1002/ejoc.201000601

专利信息

专利号:US-4190579-A
优先权日:1977-12-29
标题:Synthesis of beta-lactams from azetidine carboxylic acid esters
发明人：LIPSHUTZ BRUCE H; WASSERMAN HARRY H; WU JAMES S
权利人:RESEARCH CORP
摘要:Azetidine carboxylic acid esters are converted into enol silyl ethers which, as enamino ketene acetals, undergo ready oxidative cleavage of the ethylenically unsaturated double bond, e.g. by dye-sensitized photo-oxygenation, to form beta-lactams. The beta-lactams and substitution products thereof are useful intermediates in the synthesis of biologically active lactams.

专利号:US-11767339-B2
优先权日:2021-02-02
标 题 :Synthesis of reversible nucleotide terminators by in-situ thio-alkyl group transfer for use in DNA sequencing by synthesis
发明人：Marma Mong Sano; PERBOST MICHEL; SOLIMAN SAMEH; GUAN XIAO-PEI
权利人:MILTENYI BIOTEC BV & CO KG; MILTENYI BIOTECH B V & CO KG
摘要:The invention is directed to a method for production of a deoxynucleotide triphosphate according to general formula (7) n n n n n n n n n n n n wherein B is a nucleobase and R is an alkyl group having 1 to 4 carbon atoms and n is an integer from 1 to 10 by reaction of reaction precursor of compound 6 n n n n n n n n n n n n n n n n wherein R 1 , R 2 and R 3 are independently H, O-Alkyl with alkyl residues having 1 to 4 carbon atoms or halogen and n is an integer from 1 to 10 with dialkyl(alkylthio)sulfonium salt (8B) n n n n n n n n n n n n n n n n wherein R 4 , R 5 R 6 are independently alkyl residues having 1 to 4 carbon atoms and X is selected from the group consisting of BF 4 − , F − , Cl − , Br − , I − , SO 4 2− , SO 3 2− in aqueous solution having a pH between 3 and 7.

专利号:WO-2009047354-A1
优先权日:2007-10-12
标题:Chemo-enzymatic synthesis of a c-terminal thioester of an amino acid or a peptide
发明人：QUAEDFLIEG PETER JAN LEONARD MARIO; MERKX NICOLAAS SEBASTIAAN MICHEL
权利人:DSM IP ASSETS BV; QUAEDFLIEG PETER JAN LEONARD M; MERKX NICOLAAS SEBASTIAAN MICH
摘要:The present invention relates to a method for synthesising a C-terminal thioester of an N-protected amino acid or an optionally N-protected oligopeptide, comprising reacting a thiol with a compound selected from optionally N-protected amino acids, amino acid C-terminal esters (other than the ester to be synthesised) and optionally N-protected oligopeptide C-terminal esters (other than the ester to be synthesised) in the presence of a hydrolytic enzyme, thereby forming the thioester.

专利号:US-2011092706-A1
优先权日:2009-10-21
标题 :Process for the manufacture of enantiomerically pure aryloctanoic acids as aliskiren
发明人：SOUKUP MILAN
权利人:CarboDesign LLC
摘要:The present invention relates to a novel manufacturing process and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially rennin inhibitors such as Aliskiren. The invention describes a preparation of enantiomerically pure 8-aryloctanoic acids of general formula I from readily available key intermediate, a novel bicyclic compound of formula IV.

专利号:US-7601848-B2
优先权日:2001-12-22
标 题:Multifunctional reagent for the synthesis of thiol modified oligomers
发明人：HARTWICH GERHARD; FRISCHMANN PETER; FERRER ELISENDA
权利人:FIDICULA GMBH
摘要:The invention relates to compounds of formula (I), wherein Z represents a hydrocarbon with 2 to 28 C atoms, wherein Z can also comprise elements N, O, P, S, Si and halogen as heteroatoms, R 1 and R 2 are identical or different sulfur protecting groups, wherein both S atoms can also form a disulfide bridge and in said case R 1 and R 2 are not present; protecting group Y 1 represents protecting group NH, protecting group NR 4 , protecting group O, CONH protecting group, protecting group OOC, protecting group S—S, —CH(protecting group O) 2 or —CR 5 (protecting group O) 2 or protecting group S; Y 2 represents —OH, —NH 2 , —NHR 3 , —NR 3 R 4 , —COOH, —COCI, —COOCO—R 6 , —CONH 2 , —CONHR 3 , —COOR 3 , —SO 3 H, —SO 3C I, —SH, —S—SR 3 , —CHO, —COR 3 , —C 2 H 3 O, halogen, —N 3 , —NH—NH 2 , —NCO, —NCS, wherein R 3 represents alkyl, heteroalkyl, aryl, cycloalkyl or a protecting group, wherein R 3 can be identical or different in groups Y 1 and Y 2 , R 4 is s protecting group, wherein R 4 can be identical or different in groups Y 1 and Y 2 , and wherein R 4 and R 3 can be identical or different, R 5 represents alkyl, aryl or cycloalkyl, wherein R 5 can be identical or different in groups Y 1 and Y 2 and R 6 represents alkyl, heteroalkyl, aryl or cycloalkyl, wherein R 6 can be identical or different in groups Y 1 and Y 2 , wherein Y 2 can also represent a group of formula (II) or formula (III), wherein X 1 represents halogen or a substituted amine, X 2 represents an alkyl, alkoxy, aryloxy radical or a cyano derivative of an alkyl, alkoxy, aryloxy radical, X 3 represents halogen, an amino function or oxygen and X 4 represents an alkyl, alkoxy, aryloxy radical or X 4 equals H if X 3 =oxygen.

专利号:US-8703976-B2
优先权日:2011-10-02
标题:Manufacturing process for 8-aryloctanoic acids such as Aliskiren
发明人：SOUKUP MILAN
权利人:SOUKUP MILAN; MILAN SOUKUP
摘要:The present invention relates to a novel manufacturing process and novel intermediates useful in the synthesis of pharmaceutically active compound such as Aliskiren. n The invention describes preparation of enantiomerically pure 8-aryloctanoic acid of formula I from a chiral compound of formula IV. Friedel-Crafts reaction of this compound of formula IV with a compound of formula III provides compound of formula II which is converted reductively in a few steps into the compound of formula V, a know intermediate in the synthesis of compound of formula I. According to the disclosed process, Aliskiren can be now prepared from commercial starting materials (Guajacol or 2-bromoanisole, cis- or trans-1,4-dichloro-2-butene and 4(S)-benzyl-3-isovaleroyl-oxazolidin-2-one) in less than 8 process steps.