CAS: 54197-66-9; 6-Hydroxy-3,4-Dihydroquinolin-2(1H)-One

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CAS号19314-10-4 3-氯-N-(4-羟基苯基)丙酰胺 | CAS号7446-70-0 氯化铝 | CAS号19313-87-2 3-氯-N-(4-甲氧基苯基)-丙酰胺 | CAS号553-03-7 3,4-二氢-2(1H)-喹啉酮 | CAS号123-30-8 对氨基苯酚 | CAS号104-94-9 对甲氧基苯胺 | CAS号625-36-5 3-氯丙酰氯 | CAS号19314-15-9 3-氯-N-(4-乙氧苯基)丙酰胺 | CAS号19205-69-7 6-hydroxy-3,4-d... | CAS号87153-04-6 4'-反式羟基西洛他唑 | CAS号87152-97-4 反式-3,4-二氢-6-[4-... | CAS号865792-18-3 6-[4-(1-环己基-1H-... | CAS号73963-72-1 西洛他唑 | CAS号73963-62-9 6-[4-(1-环己基-1H-... | CAS号54197-64-7 6-甲氧基-3,4-二氢-2(... | CAS号70759-01-2 7-(3-溴丙氧基)-3,4-... | CAS号754232-89-8 6-butoxy-3,4-di... | CAS号75893-83-3 6-phenylmethoxy...

3-氯-N-(4-乙氧苯基)丙酰胺置于palladium Dichloride体系中,用 四氢呋喃 作为反应溶剂,化学反应 3.0H,以87%的收率获得产物6-羟基-3,4-二氢-2(1H)-喹诺酮
参考文献:一种6-羟基-3,4-二氢-2(1H)-喹啉酮的合成 方法
标题:一种6-羟基-3,4-二氢-2(1H)-喹啉酮的合成 方法
摘要:本发明一种6‑羟基‑3,4‑二氢‑2(1H)‑喹啉酮的合成方法,包括以下步骤:1)以对烷氧基苯胺为原料,与3‑氯‑丙酰氯反应,制得n‑(4‑烷氧基苯基)‑3‑氯丙烯酰胺;2)将步骤1)得到n‑(4‑烷氧基苯基)‑3‑氯丙烯酰胺溶于有机溶剂中,加入催化剂氯化钯,3‑5公斤的压力下,升温至100‑110oc保温反应3‑4小时,降温至室温后,过滤,滤液旋干除去有机溶剂,得到粗品6‑羟基‑3,4‑二氢‑2(1H)‑喹啉酮;3)将步骤3)得到粗品6‑羟基‑3,4‑二氢‑2(1H)‑喹啉酮重结晶,脱色,过滤,得到类白色固体6‑羟基‑3,4‑二氢‑2(1H)‑喹啉酮;本合成方法操作简单,收率高,成本更低.

专利信息

专利号:US-6048975-A
优先权日:1991-09-12
标 题:Process for the chemical synthesis of oligonucleotides
发明人：PFLEIDERER WOLFGANG; BERGMANN FRANK
权利人:HOECHST AG
摘要:A process for the chemical synthesis of oligonucleotides n Use of a dansylethoxycarbonyl group as base-labile 5'-hydroxyl protective group in the chemical synthesis of DNA and RNA and suitable synthetic processes. n The ease of detection of the dansyl protective group and the ease of elimination from the sugar residue of the nucleotide without side reactions make oligonucleotide synthesis possible with high yields in very small quantities.

专利号:US-4354972-A
优先权日:1981-06-29
标 题 :Synthesis of steroids
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:This invention relates to the synthesis of steroids which are useful for their biological activity or which may be converted to steroids which have such activity. These syntheses include the steroid compounds and processes for their preparation. n An object of the invention is to provide syntheses which are applicable to materials which are readily available in good supply for converting such materials to steroids which are useful and desirable in the manufacture of pharmaceutical products. n More particularly, I have sought to discover processes and intermediate compounds useful in the synthesis of 24, 25-dihydroxycholesterol from hyodeoxycholic acid or lithocholic acid which are constituents of, and readily available from, animal bile.

专利号:US-5945524-A
优先权日:1990-09-14
标 题 :Process for the chemical synthesis of oligonucleotides
发明人：PFLEIDERER WOLFGANG; BERGMANN FRANK
权利人:HOECHST AG
摘要:Use of a dansylethoxycarbonyl group as base-labile 5'-hydroxyl protective group in the chemical synthesis of DNA and RNA and suitable synthetic processes. n The ease of detection of the dansyl protective group and the ease of elimination from the sugar residue of the nucleotide without side reactions make oligonucleotide synthesis possible with high yields in very small quantities.

专利号:US-4794176-A
优先权日:1981-06-26
标 题 :Synthesis of tumor antigenic determinant
发明人：LEMIEUX RAYMOND U; RATCLIFFE ROBERT M; BAKER DONALD A
权利人:CHEMBIOMED
摘要:Processes are provided for the synthesis of the human T-antigenic determinant 2-acetamido-2-deoxy-3-O-(β-D-galactopyranosyl)-α-D-galactopyranoside containing an α-O-glycosidically linked bridging arm O--(CH 2 ) n COR. The determinant is coupled to carrier molecules to form artifical T-antigens, and to insoluble supports to form T-immunoadsorbents. The artificial T-antigen is shown to elicit a delayed type hypersensitivity reaction as a diagnostic for the presence of cancer in humans.

专利号:US-4767845-A
优先权日:1980-07-10
标题 :Synthesis of tumor antigenic determinant
发明人：LEMIEUX RAYMOND U; RATCLIFFE ROBERT M; BAKER DONALD A
权利人:CHEMBIOMED LTD
摘要:Processes are provided for the synthesis of the human T-antigenic determinant 2-acetamido-2-deoxy-3-O-(β-D-galactopyranosyl)-α-D-galactopyranoside containing an α-O-glycosidically linked bridging arm O--(CH 2 ) n COR. The determinant is coupled to carrier molecules to form artificial T-antigens, and to insoluble supports to form T-immunoadsorbents. The artifical T-antigen is shown to elicit a delayed type hypersensitivity reaction as a diagnostic for the presence of cancer in humans.

专利号:WO-9616071-A1
优先权日:1994-11-21
标题:PROCESSES FOR THE SYNTHESIS OF 3'-SUBSTITUTED LEWISx COMPOUNDS
发明人：SRIVASTAVA OM; IPPOLITO ROBERT; SRIVASTAVA GEETA; SZWEDA ROMAN; OHUCHI TOSHIO
权利人:GLYCOMED INC; SRIVASTAVA OM; IPPOLITO ROBERT; SRIVASTAVA GEETA; SZWEDA ROMAN; OHUCHI TOSHIO
摘要:Disclosed are processes for the chemical synthesis of 3'-substituted Lewis-OR compounds where R is an aglycon of at least one carbon atom. One particular compound prepared by the processes of this invention is 8-methoxycarbonyl-octyl-2-acetamido-3-O-( alpha -L-fucopyranosyl)-4-O-[3-O-sulfo- beta -D-galactopyranosyl]-2-deoxy- beta -D-glucopyranoside.