CAS: 54149-17-6; 1-Bromo-2-(2-Methoxyethoxy)Ethane

相似化合物

57641-66-4 72593-77-2 104518-25-4

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2-(2-methoxyethoxy)ethyl alcohol toluene-4-sulfonic acid 2-(2-methoxyethoxy)ethyl ester 1-Chloro-4-[2-(2-methoxy-ethoxy)-ethoxy]-benzene benzyl-2-(methoxyethoxy)ethylamine 2-hydroxy-3-(2-(2-methoxyethoxy)ethoxy)benzaldehyde 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-[2-(2-methoxy-ethoxy)-ethoxy]-benzamide

二乙二醇单甲醚置于吡啶,三溴化磷体系中,用 苯 作为反应溶剂,化学反应 56.0H,反应生成 1-溴-2-(2-甲氧基乙氧基)乙烷
参考文献:新的咪唑系列j774巨噬细胞特异性酰基辅酶a:胆固醇酰基转移酶(acat)抑制剂的设计,合成和结构-活性关系研究.
标题:新的咪唑系列j774巨噬细胞特异性酰基辅酶a:胆固醇酰基转移酶(acat)抑制剂的设计,合成和结构-活性关系研究.
摘要:酰基辅酶a:胆固醇酰基转移酶(acat)是参与细胞内胆固醇酯化的主要酶.巨噬细胞的动脉壁浸润和随后的胆固醇不受控制的酯化导致泡沫细胞形成被认为是导致脂肪条纹发展的重要过程.acat酶的抑制剂可能会延迟该动脉粥样硬化过程.我们最近发现了一系列咪唑,它们在j774巨噬细胞细胞培养测定中是有效的体外acat抑制剂.本文将描述这一系列非常有效的化合物的设计,合成和结构-活性关系.
DOI:10.1021/jm00007A004

专利信息

专利号:WO-9429243-A1
优先权日:1993-06-11
标 题 :Synthesis of substituted triphenylenes, useful as discotic liquid crystals
发明人：BUSHBY RICHARD JAMES; CAMMINDGE ANDREW NEIL; HEADDOCK GARETH; BORNER RUTH CAROL; BODEN NEVILLE
权利人:BRITISH TECH GROUP; BUSHBY RICHARD JAMES; CAMMINDGE ANDREW NEIL; HEADDOCK GARETH; BORNER RUTH CAROL; BODEN NEVILLE
摘要:Unsymmetrically substituted triphenylenes required in the synthesis of polymeric discotic liquid crystals are made using iron (III) chloride in organic solvent at room temperature to effect the oxidative coupling of 1,2-dialkoxybenzenes to 3,3',4,4'-tetraalkoxybiphenyls. This is followed by a reductive workup. The same oxidation-reduction protocol also proves effective in the trimerisation of 1,2-dialkoxybenzenes.

专利号:US-2003100119-A1
优先权日:1994-10-18
标题:Combinatorial synthesis and screening of supported organometallic compounds and catalysts
发明人：WEINBERG W HENRY; MCFARLAND ERIC; GOLDWASSER ISY; BOUSSIE THOMAS; TURNER HOWARD; BEEK JOHANNES A M VAN; MURPHY VINCE; POWERS TIM
权利人:SYMYX TECHNOLOGIES INC
摘要:The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.

专利号:US-6756195-B2
优先权日:1996-07-23
标题 :Polymerization method from the combinatorial synthesis and analysis of organometallic compounds and catalysts
发明人：WEINBERG W HENRY; MCFARLAND ERIC; GOLDWASSER ISY; BOUSSIE THOMAS; TURNER HOWARD; BEEK JOHANNES A M VAN; MURPHY VINCE; POWERS TIMOTHY
权利人:SYMYX TECHNOLOGIES INC
摘要:The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.

专利号:US-6440745-B1
优先权日:1994-10-18
标 题 :Combinatorial synthesis and screening of organometallic compounds and catalysts
发明人：WEINBERG W HENRY; MCFARLAND ERIC W; GOLDWASSER ISY; BOUSSIE THOMAS; TURNER HOWARD; BEEK JOHANNES A M VAN; MURPHY VINCE; POWERS TIM
权利人:SYMYX TECHNOLOGIES INC
摘要:The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents.

专利号:EP-0985678-B1
优先权日:1996-07-23
标题:Combinatorial synthesis and analysis of organometallic compounds and catalysts
发明人：WEINBERG HENRY W; MCFARLAND ERIC; GOLDWASSER ISY; BOUSSIE THOMAS; TURNER HOWARD; BEEK JOHANNES A M VAN; MURPHY VINCE; POWERS TIMOTHY
权利人:SYMYX TECHNOLOGIES INC
摘要:Methodologies for the synthesis, screening and characterisation of organometallic compounds and catalysts (eg homogenous catalysts), including combinatorial synthesis, screening and characterisation of libraries of supported and unsupported organometallic compounds and catalysts (eg homogenous catalysts). The methods can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (eg homogeneous catalysts), but also as additives and therapeutic agents.

专利号:US-2012088848-A1
优先权日:1998-03-19
标 题 :Methods and compositions for controlled polypeptide synthesis
发明人：DEMING TIMOTHY J; YU MIAOER; CURTIN SCOTT A; HWANG JUNGYEON; WYRSTA MICHAEL D; NOWAK ANDREW; SEIDEL SCOTT W
权利人:DEMING TIMOTHY J; YU MIAOER; CURTIN SCOTT A; HWANG JUNGYEON; WYRSTA MICHAEL D; NOWAK ANDREW; SEIDEL SCOTT W
摘要:Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for initiating the polymerization of aminoacid-N-carboxyanhydride (NCA) monomer by combining the monomer with an amido-containing metallacycle, for making self assembling amphiphilic block copolypeptides and related protocols for adding oligo(ethyleneglycol) functionalized aminoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains. Additional methods include means of adding an end group to the carboxy terminus of a polyaminoacid chain by reacting an alloc-protected amino acid amide with a transition metal-donor ligand complex to forming an amido-amidate metallacycle for use in further polymerization reactions. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.