CAS: 52927-22-7; 6-Hydroxy-2-Naphthonitrile

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16712-64-4 78119-82-1 130200-58-7

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3,4-二氢-2-氰基-6-甲氧基萘置于三溴化硼,2,3-二氯-5,6-二氰基-1,4-苯醌体系中,用 二氯甲烷,甲苯 作为反应溶剂,化学反应 32.0H,反应生成 6-氰基-2-萘酚
参考文献:设计,构象和晶体学的2-萘苯基苯基醚作为有效的抗艾滋病毒剂
标题:设计,构象和晶体学的2-萘苯基苯基醚作为有效的抗艾滋病毒剂
摘要:据报道,掺有7-氰基-2-萘基取代基的邻苯二酚二醚是hiv-1逆转录酶(nnrtis)的非核苷抑制剂.许多化合物对野生型hiv-1的效价为1-10 Nm.一个有趣的构象效应使得与hiv-Rt形成复合物的萘基具有两个独特的构象体.4A和4F的x射线晶体结构说明了替代方案.
DOI:10.1021/acsmedchemlett.6B00390

专利信息

专利号:US-2025188022-A1
优先权日:2022-02-07
标 题 :Process for the preparation of nafamostat, camostat and their derivatives
发明人：AHMED RIYAZ; KUMAR GULSHAN; MAHAJAN SHEENA; Verma Praveen Kumar; CHAM PANKAJ SINGH; KUMAR AMIT; AHMED QAZI NAVEED; REDDY DUMBALA SRINIVASA; SHANKAR RAVI; SINGH PARVINDER PAL
权利人:COUNCIL SCIENT IND RES
摘要:The invention provides a novel, economical and practical route for the synthesis of an ester from acid and alcoholic functionalities using Trihalotriazine as coupling agent. Specifically, the invention provides a novel, economical and practical route for the preparation of Nafamostat and Camostat. Synthesis of p-guanidinobenzoic acid (Al) was also achieved from thiourea and p-aminobenzoic acid by using trihalotriazine as coupling reagent.

专利号:US-9550000-B2
优先权日:2011-09-09
标题 :Compositions, methods, and systems for the synthesis and use of imaging agents
发明人：ROBINSON SIMON P; YU MING
权利人:ROBINSON SIMON P; YU MING; LANTHEUS MEDICAL IMAGING INC
摘要:The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs. In some embodiments, methods and compositions for assessing perfusion and innervation mismatch in a portion of a subject are provided.

专利号:CN-105152934-B
优先权日:2015-07-24
标题 :Catalytic asymmetric synthesis of axial chiral biaryl diphenols

专利号:CN-105152934-A
优先权日:2015-07-24
标 题:Catalytic asymmetric synthesis of axial chiral biaryl diphenols

专利号:US-2022339303-A1
优先权日:2011-09-09
标题 :Compositions, methods, and systems for the synthesis and use of imaging agents

专利号:EP-3567029-A1
优先权日:2011-09-09
标 题:Compositions, methods, and systems for the synthesis and use of imaging agents