CAS: 506-52-5; 1-Hexacosanol

该化合物是一种长链主要脂肪酒精,分子式为C26H54O.它是在室内温度下一种白色的蜡状固体,在水中不溶解,但在乙醇和乙醇等有机溶剂中可溶解.该化合物因其高熔点和稳定性而引人注目,适合用于化妆品,药品和工业润滑剂.其疏水特性有助于将其用作乳化剂或配方中的厚度剂.此外,已经研究过1-Hexacosanol 的潜在生物活性影响,包括其在脂质代谢中的作用.其纯度和一贯的物理特性确保了专门化学工艺的可靠性能.

结构式图片

相似化合物

506-46-7 112-30-1 112-42-5

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CAS号29030-81-7 十六烷酸乙酯-d5 | CAS号5802-82-4 蜡酸甲酯 | CAS号822-32-2 1-乙酸二十六酯 | CAS号69532-93-0 hexacosanoic ac... | CAS号505-95-3 端羟基12酸 | CAS号73367-80-3 12-溴十二烷酸 | CAS号102945-07-3 2-°Ctadecylthiophene | CAS号111514-83-1 methyl 4-(5-°Ct... | CAS号111514-94-4 methyl 3-(2-(5-... | CAS号506-46-7 蜡酸 | CAS号26627-85-0 正二十六烷醛 | CAS号7719-79-1 五十二烷 | CAS号822-32-2 1-乙酸二十六酯 | CAS号4276-51-1 Hexacosane, 1-bromo | CAS号58886-94-5 °Ctadecanoic ac...

合成工艺路线路线简述

    12-羟基十二酸置于lithium Aluminium Tetrahydride,Dilithium Tetrachlorocuprate,氢溴酸,Sodium Ethanolate体系中,用 四氢呋喃,乙醇,溶剂黄146 作为反应溶剂,化学反应 9.5H,反应生成 二十六碳醇
    参考文献:Zakharkin,L. I.; Churilova,I. M.; Anikina,E. V.,Journal Of Organic Chemistry Ussr (English Translation),1988,Vol. 24,P. 65-67
    标题:Zakharkin,L. I.; Churilova,I. M.; Anikina,E. V.,Journal Of Organic Chemistry Ussr (English Translation),1988,Vol. 24,P. 65-67

    海关参考信息

    专利信息


    专利号:US-6022977-A
    优先权日:1997-03-26
    标 题 :Dynamic resolution of isoxazoline thioesters to isoxazoline carboxylic acids
    发明人:ZHANG LIN-HUA; ANZALONE LUIGI; PESTI JAAN A; YIN JIANGUO
    权利人:DU PONT PHARM CO
    摘要:The present invention relates generally to a novel method for preparation of substituted isoxazolin-5-yl acetic acid in high optical purity from a stereoisomeric mixture of an esterified substituted isoxazolin-5-yl acetate. The products are useful in the synthesis of compounds for pharmaceuticals, especially the treatment of thrombolytic disorders, and agricultural products.

    专利号:US-8329854-B2
    优先权日:2010-09-27
    标题 :Synthesis of tri-component resins
    发明人:BIRAU MARIA; ALLEN C GEOFFREY
    权利人:BIRAU MARIA; ALLEN C GEOFFREY; XEROX CORP
    摘要:A resinous compound of the formulas or a salt thereof, wherein G1 is —X1C(O)OR1, —X2OC(O)R2, or —X2OH; G2 is R4, R12, —C(O)R2, —C(O)X1C(O)OR1, or —C(O)X2OC(O)R2; R1 is an alkyl having from 10 to 80 carbon atoms; R2 is an alkyl having from 2 to 40 carbon atoms; each R3 and R4 is independently hydrogen, alkyl, arylalkyl or alkylaryl; each R5 and each R6 is independently hydrogen or alkyl; X1 and X2 are both a straight or branched alkylene group; t1 is 1 to 20; t2 and t3 is independently 0 to 20; u1 is 1 to 30; u2 and u3 is independently 0 to 30; each R7 and each R8 is independently hydrogen, alkyl, or alkoxyl; each R9 and each R10 is independently hydrogen, alkyl, or alkoxyl; Ar is a substituted or unsubstituted aromatic moiety; p is 1 to 5; q is 1 to 12; A⊖ is selected from the group consisting of Cl−, Br−, I−, HSO4−, HSO3−, CH3SO3−, NO3−, HCOO−, CH3COO−, H2PO4−, SCN−, BF4−, ClO4−, SSO3−, PF6−, and SbCl6−; and J is alkyl, arylalkyl, or alkylaryl.

    专利号:US-9365532-B1
    优先权日:2011-02-14
    标题:Synthesis, composition and use of novel therapeutic and cosmetic Schiff base products formed by reaction of a carbonyl containing moeity with a transimination nucleophilic catalyst and the use of transimination nucleophilic catalysts to increase the rate at which carbonyl containing therapeutic and cosmetic actives form Schiff base products with biological amines
    发明人:ISAACMAN STEVEN
    权利人:ISAACMAN STEVEN; NANOMETICS LLC
    摘要:The present invention relates to the synthesis, composition and use of novel moieties formed by reacting a transimination nucleophilic catalyst, molecular or polymeric, with carbonyl-containing therapeutic or cosmetic moieties. The resultant Schiff base product is highly reactive towards transimination with a biological amine. The catalyst and carbonyl-containing moiety can be molecular or polymeric, and the resultant chemical and physical properties of the Schiff base products can be engineered by appropriate selection of said catalyst. The present invention also relates to the synthesis, composition and use of novel moieties that are used as actives in sunless tanning preparations. The present invention also relates to the use of transimination nucleophilic catalysts to increase the rate at which a carbonyl-containing moiety reacts with a biological amine. The present invention also relates to the use of transimination nucleophilic catalysts to increase the rate and efficacy of commercial sunless tanning preparations. Improvements on stability and efficacy of said preparations are disclosed. While the invention has been described in terms of its preferred embodiments, those skilled in the art will recognize that the invention can be practiced with modification within the spirit and scope of the appended claims. Accordingly, the present invention should not be limited to the embodiments as described above, but should further include all modifications and equivalents thereof within the spirit and scope of the description provided herein.

    专利号:US-2018312534-A1
    优先权日:2015-10-16
    标题:Fluorescent anticancer platinum drugs
    发明人:SARKAR ARINDAM; MANDAL SWADHIN KUMAR; SENGUPTA ANIRUDDHA; BISWAS GOUTAM; DUTTA PRADIP; SHARMA RUPALI; RAJ JUSTIN PAUL; SURYAVANSHI HEMANT; KUMARI SMITA
    权利人:INVICTUS ONCOLOGY PVT LTD
    摘要:The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to fluorescent platinum based compounds. The disclosure further relates to synthesis of said fluorescent platinum based compounds, nanoparticles and compositions comprising said fluorescent platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by the fluorescence changes between aforesaid platinum based compounds and corresponding free ligands, nanoparticles and compositions.

    专利号:US-10730899-B2
    优先权日:2013-06-14
    标 题 :Lipid-based platinum compounds and nanoparticles
    发明人:SENGUPTA SHILADITYA; ROY MONIDEEPA; SARKAR ARINDAM; HOSSAIN SK SAMAD; SENGUPTA ANIRUDDHA; DUTTA PRADIP; ANSARI AASIF
    权利人:AKAMARA THERAPEUTICS INC
    摘要:The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to platinum based compounds comprising platinum moiety, linker moiety and lipid moiety and corresponding nanoparticles thereof. The disclosure further relates to synthesis of said platinum based compounds, nanoparticles and compositions comprising said platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by employing aforesaid carbene compounds, platinum based compounds, nanoparticles and compositions thereof.

    专利号:CN-104910009-A
    优先权日:2015-06-25
    标题 :A kind of method of ionic liquid catalyzed synthesis of pletil alcohol ester
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    主要参考文献

    [参考文献]: C Damgé, Et Al. Effect Of N-Hexacosanol On Insulin Secretion In The Rat. Eur J Pharmacol. 1995 Feb 14;274(1-3):133-9.
    [参考文献]: Chiko Shinbori, Et Al. N-Hexacosanol Reverses Diabetic Induced Muscarinic Hypercontractility Of Ileum In The Rat. Eur J Pharmacol. 2006 Sep 18;545(2-3):177-84.
    [参考文献]: Dong Min Jung, Et Al. A Gas Chromatography-Tandem Quadrupole Mass Spectrometric Analysis Of Policosanols In Commercial Vegetable Oils. J Food Sci. 2011 Aug;76(6):C891-9.
    [参考文献]: Hiroto Suzuki, Et Al. Preventive Effects Of Cyclohexenonic Long-Chain Fatty Alcohol On Diabetic Cystopathy In The Rat. Can J Physiol Pharmacol. 2006 Feb;84(2):195-201.
    [参考文献]: J Borg, Et Al. Peripheral Administration Of A Long-Chain Fatty Alcohol Promotes Septal Cholinergic Neurons Survival After Fimbria-Fornix Transection. Brain Res. 1990 Jun 4;518(1-2):295-8.

    合成参考文献


    参考文献:10.1007/s10661-005-9102-8
    摘要:Rushdi AI, Al-Zarban S, Simoneit BRT. Chemical Compositions and Sources of Organic Matter in Fine Particles of Soils and Sands from the Vicinity of Kuwait City. Environmental Monitoring and Assessment. 2006 Jun 07;120(1-3):537–57. doi: 10.1007/s10661-005-9102-8.
    参考文献:10.1007/s10886-012-0231-6
    摘要:Schulz S. Spider Pheromones – a Structural Perspective. Journal of Chemical Ecology. 2012 Dec 27;39(1):1–14. doi: 10.1007/s10886-012-0231-6.
    摘要:Cabrera L, Uribarri E, Laguna A, Sierra R, Mederos D, González M, González V. Study of the interaction between policosanol and excipients. Boll Chim Farm. 2002 Mar;141(2):138–42.
    参考文献:10.1007/s11010-008-9804-7
    摘要:Okada S, Saito M, Kazuyama E, Hanada T, Kawaba Y, Hayashi A, Satoh K, Kanzaki S. Effects of N-hexacosanol on nitric oxide synthase system in diabetic rat nephropathy. Molecular and Cellular Biochemistry. 2008 Jun 05;315(1-2):169–77. doi: 10.1007/s11010-008-9804-7.
    参考文献:10.1093/jxb/erq002
    摘要:Ebert B, Zöller D, Erban A, Fehrle I, Hartmann J, Niehl A, Kopka J, Fisahn J. Metabolic profiling of Arabidopsis thaliana epidermal cells. J Exp Bot. 2010 Mar;61(5):1321–35.
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