CAS: 487-79-6; (2S,3S,4S)-3-(Carboxymethyl)-4-(Prop-1-En-2-yl)Pyrrolidine-2-Carboxylic Acid

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CAS号139407-08-2 (2S,3S,4S)-4-is... | CAS号329055-36-9 ethyl 2-((2R,3S... | CAS号1293306-04-3 di-tert-butyl (... | CAS号1259067-20-3 (2S,3S,4S)-meth... | CAS号115890-38-5 (R)-benzyl (1-(... | CAS号108365-31-7 kainic acid dim... | CAS号487-79-6 海藻酸(mM/ml) | CAS号52497-36-6 二氢红藻氨酸

(3As,3Bs)-6-Methyl-3A,3B,4,7-Tetrahydro-3H-2-Oxa-7A-Azacyclopentapentalene-1,5-Dione置于palladium On Activated Charcoal 盐酸,六甲基磷酰三胺,Iron(II) Oxide,Lithium Hydroxide,重铬酸吡啶,二甲基硫,4 A Molecular Sieve,氨,氢气,Lithium,臭氧,三乙胺,N,N-二异丙基乙胺,三氟乙酸体系中,用 四氢呋喃,甲醇,乙醚,正己烷,二氯甲烷,乙酸乙酯,N,N-二甲基甲酰胺 作为反应溶剂,-78.0~25.0 °C,101.33 Kpa 条件下,反应 34.67H,反应生成 红藻氨酸
参考文献:A Total Synthesis Of (-)-.Alpha.-Kainic Acid Involving A Pauson-Khand Reaction As The Key Step
标题:A Total Synthesis Of (-)-.Alpha.-Kainic Acid Involving A Pauson-Khand Reaction As The Key Step
摘要:A Synthetic Route To (-)-Alpha-Kainic Acid Has Been Developed Based On The Pauson-Khand Reaction As A Key Step For The Construction Of The Bicyclic Ring System. In This Reaction A Built-In Oxazolidinone Ring Serves As A Rigid Template For Good Diastereofacial Selectivity.
DOI:10.1021/jo00102A021

专利信息

专利号:US-5338851-A
优先权日:1993-03-31
标 题:Synthesis of cis-decahydroisoquinoline-3-carboxylic acids
发明人：HUFF BRET E; KHAU VIEN V; MARTINELLI MICHAEL J; PETERSON BARRY C
权利人:LILLY CO ELI
摘要:This invention provides a process for the synthesis of cis-decahydroisoquinoline-3-carboxylic acids and provides intermediates in the synthesis thereof.

专利号:US-7955816-B2
优先权日:2006-05-02
标 题 :Design and synthesis of biotinylated probes for N-acyl-ethanolamines
发明人：MACCARRONE MAURO; ODDI SERGIO; FEZZA FILOMENA; FINAZZI AGRO′ ALESSANDRO
权利人:UNI DEGLI STUDI DI ROMA & LDQUO TOR VERGATA & RDQUO; UNI DEGLI STUDI DI TERAMO
摘要:The present invention relates to the synthesis and characterization of biotinylated analogue of N-arachidonoylethanolamine (AEA) and its use as a tool to study AEA transport and trafficking through biochemical and morphological techniques. In particular biotinylated AEA (b-AEA, for which we propose the common name MM22) is suitable to design highly sensitive and simple methods for the non-radioactive detection and quantitation of AEA from complex samples, which would offer a useful alternative approach to the routinely used radiometric assays. The invention also relates to the use of b-AEA as a potential therapeutic and diagnostic agent.

专利号:US-6362009-B1
优先权日:1997-11-21
标 题 :Solid phase synthesis of heterocycles
发明人：MUNOZ BENITO; CHEN CHIXU
权利人:MERCK & CO INC
摘要:Methods for solid phase and combinatorial synthesis using a resin activation/capture approach are provided. In particular, methods for the production of dihydropyridones, N-acyidihydropyridones, tetrahydropyridones, pyridines, aminopyridines, N-acyltetrahydropyridines and tetrahydropyridines compounds and libraries containing such compounds are provided. Methods for screening the libraries and compounds and pharmaceutical compositions containing compounds prepared by the methods are provided.

专利号:US-5591867-A
优先权日:1992-12-04
标 题 :Synthesis of kainic acid
发明人：MONN JAMES A
权利人:LILLY CO ELI
摘要:This invention provides a process for preparing kainic acid and provides intermediates in the synthesis thereof.

专利号:US-8008459-B2
优先权日:2001-01-25
标 题 :Concatemers of differentially expressed multiple genes
发明人：GOLDSMITH NEIL; SORENSEN ALEXANDRA M P SANTANA; NIELSEN SOREN V S; NAESBY MICHAEL
权利人:EVOLVA SA
摘要:In the present invention are disclosed concatemers of concatenated expression cassettes and vectors that enable the synthesis of such concatemers. The concatemer comprises in the 5′→3′ direction a cassette of nucleotide sequence of the general formula [rs2-SP-PR-X-TR-SP-rs1]n wherein rs1 and rs2 together denote a functional restriction site, SP individually denotes a spacer of at least two nucleotide bases, PR denotes a promoter, capable of functioning in a cell, X denotes an expressible nucleotide sequence, TR denotes a terminator, and SP individually denotes a spacer of at least two nucleotide bases, and n>/=2, and wherein at least a first cassette is different from a second cassette. The main purpose of these concatemers is the controllable and co-ordinated expression of large numbers of heterologous genes in a single host. Furthermore, the invention relates to a concatemer of cassettes of nucleotide sequences and a method for preparing the concatemers. In a further aspect, the invention relates to transgenic host cells comprising at least one concatemer according to the invention, as well as to a method for preparing the transgenic host cells. Finally, the invention relates to a vector comprising a cassette of nucleotides, a method for preparing said vector, a nucleotide library comprising at least two primary vectors each comprising a cassette of nucleotides, a method for preparing the library.

专利号:US-5624660-A
优先权日:1995-06-06
标题 :Stress response imaging by detection of decreased protein synthesis
发明人：SHARP FRANK R
权利人:UNIV CALIFORNIA
摘要:Physiological conditions in a subject which result in a reduction in the rate of protein synthesis are detected by the administration of a labeled amino acid, followed by imaging of the subject's body to detect the uptake of the labeled amino acid in protein synthesis. The method is particularly useful as applied to the detection of ischemic events, focal or global, as well as hypoglycemia and status epilepticus.