CAS: 402-23-3; 1-(Bromomethyl)-3-(Trifluoromethyl)Benzene

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CAS号349-75-7 3-(三氟甲基)苄醇 | CAS号454-89-7 间三氟甲基苯甲醛 | CAS号401-79-6 3-甲基三氟甲苯 | CAS号402-26-6 间(三氟甲基)苯基溴化镁 | CAS号351-35-9 3-(三氟甲基)苯乙酸 | CAS号380427-19-0 3-METHOXY-4-([3... | CAS号90390-07-1 N-甲基-3-三氟甲基苄胺 | CAS号226905-70-0 2-chloro-5-meth... | CAS号343604-08-0 3-{[3-(三氟甲基)苄基]... | CAS号2740-83-2 3-(三氟甲基)苯甲胺 | CAS号437761-03-0 4-methyl-N'-((E... | CAS号63701-37-1 3-三氟甲基-DL-苯丙氨酸 | CAS号102859-64-3 [3-(trifluorome... | CAS号2338-76-3 间三氟甲基苯乙腈

3-三氟甲基苯甲醇置于三溴化磷体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 3-(三氟甲基)溴苄
参考文献:新型吡唑酰胺衍生物的设计,合成及抗真菌活性
标题:新型吡唑酰胺衍生物的设计,合成及抗真菌活性
摘要:借助活性亚结构剪接策略,设计合成了36种新型吡啶环吡唑酰胺衍生物.这些化合物的结构通过1 H NMR,13 C NMR,Ft-Ir 和 Hrms 进行了确证和表征.化合物2I经x射线晶体衍射鉴定.吡唑酰胺衍生物对四种植物病原性真菌胶孢炭疽菌,尖孢镰刀菌,黑孢镰刀菌和串珠镰刀菌的杀真菌作用通过菌丝体生长速率来确定.结果表明,设计的化合物在200 Mg/l浓度下具有一定的抗真菌活性.与阳性对照多菌灵相比,化合物1E,1G和1H对sphaeropsis Sapinea和fusarium Moniliforme表现出较强的抗真菌活性.化合物1A-1S(r 1 = H)的抗真菌活性优于化合物2A-2P(r 1 = Ch 3).化合物1D,1E,1G,1H,1I,2G和2I表现出非常好的抗真菌活性,在苯环上引入卤素基团(f除外)可能对生物活性有重要影响.化合物1G对多种植物病原真菌的生长有较好的抑制作用.分子对接显示-Ch
DOI:10.1016/j.Molstruc.2022.134881

专利信息

专利号:WO-0140193-A1
优先权日:1999-12-03
标题:Method for the synthesis of pyrazolines
发明人：BOLDI ARMEN M
权利人:CHEMRX ADVANCED TECHNOLOGIES I; BOLDI ARMEN M
摘要:The present invention provides a method for the synthesis of compounds of Formula (I). Also claimed are novel intermediates and their methods of synthesis.

专利号:US-2002103381-A1
优先权日:2000-11-30
标 题 :Method for the synthesis of pyrazolines
发明人：BOLDI ARMEN M
摘要:The present invention provides a method for the synthesis of compounds of Formula I: n n n Also claimed are novel intermediates and their methods of synthesis.

专利号:WO-2008103866-A1
优先权日:2007-02-22
标题 :Synthesis of indoles
发明人：TALLEY JOHN JEFFREY; RENZE JUERGEN T
权利人:MICROBIA INC; TALLEY JOHN JEFFREY; RENZE JUERGEN T
摘要:Method for preparing indoles, including methods that permit high yield production of particular compounds, are described.

专利号:US-6150129-A
优先权日:1996-08-01
标 题 :Antimicrobial determination of N-(aminoalkyl) and/or N-(Amidoalkyl) dinitrogen heterocyclic compositions
发明人：COOK PHILLIP DAN; KAWASAKI ANDREW M; KUNG PEI PEI
权利人:ISIS PHARMACEUTICALS INC
摘要:Compositions are provided comprising novel di-nitrogen heterocycle compounds containing N-(aminoalkyl) and/or N-(amidoalkyl) groups. An additional situs of functionality is also provided. The compounds and compositions of the invention are useful as antibacterial and other pharmaceutical agents and as intermediates for preparation of other pharmaceutical agents. In addition, compounds of the present invention are useful as research reagents including employment as species for effecting combinatorial synthesis.

专利号:US-2023192718-A1
优先权日:2018-03-30
标 题 :Bicyclic enone carboxylates as modulators of transporters and uses thereof
发明人：SANDANAYAKA VINCENT
权利人:NIROGY THERAPEUTICS INC
摘要:The invention generally relates to the field of monocarboxylate transporter inhibitors, and more particularly to new bicyclic enone carboxylate enone compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with monocarboxylate transporter activity such as in treating cancer and other neoplastic disorders, tissue and organ transplant rejection.

专利号:US-2011152295-A1
优先权日:2008-09-08
标 题:Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LECLERC JEAN-PHILIPPE; LI CHUN SING; RAMTOHUL YEEMAN K
权利人:LECLERC JEAN-PHILIPPE; LI CHUN SING; RAMTOHUL YEEMAN K
摘要:Heteroaromatic compounds of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.