CAS: 39608-31-6; N-((Benzyloxy)Carbonyl)-N-Methylglycine

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📜Ethyl 2-(((Benzyloxy)Carbonyl)(Methyl)Amino)Acetate置于水,Lithium Hydroxide,盐酸体系中,用 四氢呋喃,甲醇,水 作为反应溶剂,化学反应 3.0H,反应生成 苄氧羰酰基肌氨酸
参考文献: Cyclohexyl-Azetidinyl Antagonists Of Ccr2[fr] Antagonistes Du Ccr2 à Base De Cyclohexyl-Azétidinyle
标题: Cyclohexyl-Azetidinyl Antagonists Of Ccr2[fr] Antagonistes Du Ccr2 à Base De Cyclohexyl-Azétidinyle
摘要:本发明包括公式(I)的化合物.其中:R1,R2,R4,J,Q和a如说明书所述定义.本发明还包括预防,治疗或改善综合征,障碍或疾病的方法,其中所述综合征,障碍或疾病为2型糖尿病,肥胖和哮喘.本发明还包括通过管理治疗有效量的至少一种公式(I)化合物来抑制哺乳动物中的ccr2活性的方法.

专利信息

专利号:US-2025091989-A1
优先权日:2023-09-19
标 题 :Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-5021550-A
优先权日:1986-10-07
标 题 :Method for preventing deletion sequences in solid phase synthesis
发明人：ZEIGER ALLEN R
权利人:UNIV JEFFERSON
摘要:Improved methods for solid-state synthesis of polymers, especially polypeptides and polynucleotides, are provided. In accordance with a preferred embodiment, selectively activatable and reactive bonding moieties are covalently bonded to solid supports for polynucleotide and polypeptide syntheses. Products of failed reactions and some side products are caused to react with the selectively activatable and reactive bonding moiety to cause divalent bonding of unwanted products to the solid support. Upon cleavage of the initial situs of covalent bonding to the solid support, desired products are free to be collected while unwanted products remain covalently bonded to the support. Ease of purification of such polymers is a principal object of the present invention. The methods of the invention are amenable to automation and digital control and novel solid supports, activatable, reactive bonding moieties and other compositions are presented. The expression of polynucleotides prepared in accordance with preferred embodiments produces novel polypeptides.

专利号:US-RE29669-E
优先权日:1973-04-23
标 题:Production of 4-hydroxy-1,2-benzothiazine-3-carboxamides
摘要:A process for the synthesis of N-aryl-3,4-dihydro-2-alkyl-4-oxo-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides by treatment of N-aryl-N'-alkyl-N'-(2'-alkoxycarbonylbenzenesulfonyl)glycineamides, useful intermediates for said process, with an alkali or alkaline earth metal hydride in a reaction-inert solvent at 50°-150° C., said products being antiinflammatory agents.

专利号:US-4250086-A
优先权日:1979-11-19
标 题:Method and composition for preparation of H-SAR-LYS-SAR-GLN-NH2
发明人：HEAVNER GEORGE
权利人:ORTHO PHARMA CORP
摘要:A method for solution synthesis of H-SAR-LYS-SAR-GLN-NH2 in good yield and compositions useful therein are disclosed.

专利号:US-9035061-B2
优先权日:2010-07-13
标题:Process for preparing a biphenyl-2-ylcarbamic acid
发明人：COLSON PIERRE-JEAN
权利人:COLSON PIERRE-JEAN; THERAVANCE BIOPHARMA R & D IP LLC
摘要:The invention provides a process of preparing an intermediate useful in the synthesis of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester, and a process of preparing a crystalline freebase of the ester.

专利号:US-4369137-A
优先权日:1980-06-17
标 题 :N-Protected pentapeptides useful as intermediates in the preparation of thymopoietin pentapeptide
发明人：HEAVNER GEORGE
权利人:ORTHO PHARMA CORP
摘要:The present invention relates to methods for preparing useful peptides, more particularly to solution synthesis methods for preparing H-ARG-X-Z-Y-TYR-R, intermediates in the preparation of this peptide and to compositions of this peptide useful in thymic function.