CAS: 39537-23-0; (S)-5-Amino-2-((S)-2-Aminopropanamido)-5-Oxopentanoic Acid

相似化合物

21467-17-4 3929-61-1 656221-79-3

上下游产品

CAS号56-85-9 L-谷氨酰胺 | CAS号1142-20-7 |N|-苄氧羰基-L-丙氨酸 | CAS号5872-22-0 (2S)-2-(2,2-dim... | CAS号21467-17-4 (S)-5-氨基-2-((S)... | CAS号4652-65-7 N-苄氧羰基-L-谷氨酸- 5-甲酯 | CAS号56-41-7 L-丙氨酸 | CAS号56-85-9 L-谷氨酰胺 | CAS号290312-62-8 丙氨酰丙氨酰谷氨酰胺

N-(α-Chloro)Propionyl-L-Glutamine置于ammonium Hydroxide体系中,用 水 作为反应溶剂,60.0 °C,200.0 Kpa 条件下,反应生成 L-丙氨酰-L-谷氨酰胺
参考文献:Alanyl Glutamine Compound And Preparation Method Thereof
标题:Alanyl Glutamine Compound And Preparation Method Thereof
摘要:制备纯丙氨酰谷氨酰胺的过程包括以下步骤:1)将n-(α-氯代)-丙酰谷氨酰胺与肼化合物反应,得到丙氨酰谷氨酰胺粗品;2)混合无水甲醇和丙氨酰谷氨酰胺粗品以提供过滤蛋糕;3)将过滤蛋糕溶解在水中,加热,加入乙醇,冷却以得到纯丙氨酰谷氨酰胺.

专利信息

专利号:US-2023398215-A1
优先权日:2020-10-28
标 题:Genetically engineered antigen-specific natural killer cells for in situ synthesis of proteins
发明人：BHATNAGAR PARIJAT
权利人:STANFORD RES INST INT
摘要:An example genetically engineered natural killer (NK) cell comprises an exogenous polynucleotide sequence that includes a receptor element, an actuator element, and an effector element. The receptor element encodes a chimeric antigen receptor (CAR) comprising an extracellular antigen binding domain operably linked to a transmembrane domain, and an intracellular signaling domain, wherein the extracellular antigen binding domain recognizes a surface antigen of a target cell. The actuator element encodes a transcription factor binding site that upregulates synthesis of an effector protein. The effector element encodes the effector protein operably linked to a signal peptide, wherein, in response to the antigen binding domain of the CAR binding to the antigen of the target cell, the engineered NK cell is configured to activate and, to synthesize and secrete the effector protein.

专利号:US-2003049619-A1
优先权日:2001-03-21
标题 :Methods for the synthesis of polynucleotides and combinatorial libraries of polynucleotides
发明人：DELAGRAVE SIMON; MARRS BARRY
摘要:Methods for the synthesis of polynucleotides and derivatives thereof are provided. Methods for the preparation of combinatorial libraries of polynucleotides are also provided. In addition, methods for the preparation and identification of polynucleotides having a predetermined property are provided.

专利号:US-12037623-B2
优先权日:2018-07-09
标 题 :Enzymatic synthesis of 4′-ethynyl nucleoside analogs
发明人：HUFFMAN MARK A; FRYSZKOWSKA ANNA; KOLEV JOSHUA N; DEVINE PAUL N; CAMPOS KEVIN R; TRUPPO MATTHEW; NAWRAT CHRISTOPHER C
权利人:MERCK SHARP & DOHME; MERCK SHARP & DOHME LLC
摘要:The present invention relates to an enzymatic synthesis of 4′-ethynyl-2′-deoxy nucleosides and analogs thereof, for example EFdA, that eliminates the use of protecting groups on the intermediates, improves the stereoselectivity of glycosylation and reduces the number of process steps needed to make said compounds. It also relates to the novel intermediates employed in the process.

专利号:US-2017283878-A1
优先权日:2015-12-11
标题:Modulation of globoseries glycosphingolipid synthesis and cancer biomarkers
发明人：WONG CHI-HUEY; WU CHUNG-YI; CHEUNG SARAH K C; CHUANG PO-KAI; HSU TSUI-LING
权利人:ACADEMIA SINICA
摘要:The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for diagnostic and therapeutic uses.

专利号:US-2024082118-A1
优先权日:2021-05-19
标 题:Topical compositions and methods of preparing the same
发明人：ABRAMOVICH SAGI; AVIDOR GAL; LANDA BENZION
权利人:LANDA LABS 2012 LTD
摘要:There is disclosed a composition comprising a water-insoluble thermoplastic compound capable of stimulating collagen synthesis (CSSC), the CSSC having a molecular weight of more than 0.6 kDa and being dispersed in a polar carrier as nano-elements having an average diameter of 200 nm or less and a viscosity of 107 mPa·s or less. The nano-elements of CSSC can be capable of stimulating the synthesis of skin proteins and/or enabling the delivery of active agents upon their application to a surface to be treated therewith. Methods for preparing the compositions and uses thereof are also provided.

专利号:US-2025043248-A1
优先权日:2023-08-04
标题:Preparation method and use of hydrogel material for growth of blood vessel organoids
发明人：SUN DI; SUN JIAMING; WANG ZHENXING; LEI SHIZE
权利人:UNION HOSPITAL TONGJI MEDICAL COLLEGE HUST
摘要:The present disclosure provides a preparation method and use of a hydrogel material for growth of blood vessel organoids (BVOs). The preparation method of the hydrogel material includes: (1) synthesis of gelatin methacryloyl (GelMA), and (2) synthesis of ns-GelMA-PEO. The hydrogel material may be used for in vitro cultivation of BVOs. The hydrogel material ns-GelMA-PEO prepared by the present disclosure may significantly improve the survival and budding abilities of BVOs. The ns-GelMA-PEO provides a novel solution for in vitro cultivation of BVOs, and may well support the growth and differentiation of organoids.