CAS: 368-77-4; 3-(Trifluoromethyl)Benzonitrile

上下游产品

3-trifluoromethylaniline benzene-1,3-dicarbonitrile ethanedinitrile α,α,α-trifluorotoluene 3'-(trifluoromethyl)acetophenone 3-(trifluoromethyl)benzoic acid 3-Trifluoromethylbenzaldehyde 3-(TRIFLUOROMETHYL)BENZYLAMINE

3-三氟甲基苯甲醇置于硫酰氟,盐酸羟胺,Potassium Carbonate,二甲基亚砜体系中,化学反应 24.0H,反应生成间三氟甲基苯腈
参考文献:So2F2介导的无过渡金属一锅级联过程,用于将初级醇(rch2Oh)转化为腈(rcn)
标题:So2F2介导的无过渡金属一锅级联过程,用于将初级醇(rch2Oh)转化为腈(rcn)
摘要:在不引入"额外碳原子"的情况下,开发了一种新的无过渡金属的单锅级联工艺,用于将醇直接转化为腈.该方案允许将容易获得,廉价和丰富的醇转化为高价值的腈.
Doi:10.1002/ejoc.201900478

专利信息

专利号:WO-2013091696-A1
优先权日:2011-12-21
标题 :Synthesis of intermediates for preparing anacetrapib and derivatives thereof
发明人：HUMLJAN JAN; MARAS NENAD
权利人:LEK PHARMACEUTICALS; HUMLJAN JAN; MARAS NENAD
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:EP-2468735-A1
优先权日:2010-12-23
标 题:Synthesis of intermediates for preparing anacetrapib and derivates thereof
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:US-9212118-B2
优先权日:2010-12-23
标题:Synthesis of intermediates for preparing anacetrapib and derivatives thereof
发明人：HUMLJAN JAN; MARAS NENAD
权利人:HUMLJAN JAN; MARAS NENAD; LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.

专利号:US-4822903-A
优先权日:1981-05-15
标题:Fluorinated silica catalyst and preparation of aromatic/aliphatic nitriles in the presence thereof
发明人：JACQUES ROLAND; REPPELIN MICHEL; SEIGNEURIN LAURENT
权利人:RHONE POULENC SPEC CHIM
摘要:An improved fluorinated siliceous catalyst, well adapted for the catalytic synthesis of aromatic/aliphatic nitriles from their corresponding formamides, formanilides or amides, is comprised of a plurality of silica particulates, the specific surface of which ranging from about 200 to about 300 m 2 /g, having a total pore volume ranging from about 1 to about 1.5 cm 3 /g, with an average pore diameter ranging from about 100 to about 200 â„«, having an exchange pH of less than about 3, and with the fluorine content thereof bonded to the silica, expressed in F 31 , ranging from about 0.05 to about 2% by weight based upon the silica, and the sodium content thereof, expressed as Na 2 O, being less than about 1% by weight, also based upon the silica.

专利号:US-6380436-B1
优先权日:1998-05-12
标 题 :Process for the synthesis of alkoxyalkyl (trifluormethylphenyl) methanones
发明人：THENNATI RAJAMANNAR; DEO KESHAV; MIDHA AJAY SOHANLAL; CHANDRA TILAK; PATEL VIJAY MULJIHHAI
权利人:SUN PHARMACEUTICAL IND LTD
摘要:A new process is described for the preparation of (alkoxyalkyl)(4-trifluoromethylphenyl)methanones. The process comprises reacting a 4-trifluoromethylbenzonitrile with an alkoxyalkyl Grignard in the presence of a suitable polar aprotic solvent. The compound (4-methoxybutyl)(4-trifluoromethylphenyl)methanone is useful as an intermediate in the preparation of the antidepressant drug fluvoxamine.

专利号:US-7569606-B2
优先权日:2006-01-26
标 题 :Platinum complexes with mononitrile-containing ligands
发明人：XIAO ZEJUN; HAUSHEER FREDERICK H; PETLURU PAVANKUMAR
权利人:BIONUMERIK PHARMACEUTICALS INC
摘要:Disclosed herein are novel platinum-based complexes possessing one nitrile substituent group (mononitrile) covalently-bonded to the platinum, one or more nitrogen donor ligands capable of forming hydrogen bonds with the bases in DNA or RNA and leaving groups (i.e., L 1 and L 2 )which can be hydrolyzed iii vivo to active species, which can then form coordinate adducts with DNA or RNA at the Guanine or Adenine bases thereof. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as well as methods of treatment of various types of cancer by the administration of a pharmaceutically-effective dose of said novel platinum complexes.