CAS: 3332-29-4; O-Ethylhydroxylamine Hydrochloride

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624-86-2 21663-79-6 38945-21-0

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CAS号624-86-2 O-乙基羟胺 | CAS号22509-51-9 N-ethoxybenzamide | CAS号1914-21-2 2-乙氧基-1H-异吲哚-1,... | CAS号22509-51-9 N-ethoxybenzamide | CAS号70176-29-3 N-ethoxy-2,6-di... | CAS号7251-32-3 diethyl 2-(diet... | CAS号90324-77-9 (7CI)-3-乙氧基-1,1... | CAS号643042-50-6 (9CI)-N-(4-氟苯基)...

O-乙基羟胺置于盐酸体系中,用7.2 Kg的收率获得产物乙氧基胺盐酸盐
参考文献:一锅法制备o-烷基羟胺盐酸盐和n,O-二烷基羟胺盐酸盐的方法
标题:一锅法制备o-烷基羟胺盐酸盐和n,O-二烷基羟胺盐酸盐的方法
摘要:本发明涉及有机合成领域,具体为一锅法制备0‑烷基羟胺盐酸盐和n,O‑二烷基羟胺盐酸盐的方法,包括以下步骤:S1乙酰化:盐酸羟胺与水以及乙酸甲酯混合,室温搅拌下滴加氢氧化钠溶液,得中间体乙酰羟胺;s2烷基化:常温下向反应釜内滴加烷基化试剂后升温反应;s3水解纯化:反应合格后加入浓硫酸升温水解,合格后加入片碱或液碱调ph=12,常压蒸馏后用盐酸酸化,冷却结晶,离心烘干得到最终产品;本发明选用乙酸甲酯作为乙酰保护剂,与乙酸乙酯相比具有以下优点:水溶性好,反应位阻小,保护充分,杂质少以及价格成本低等优点;同时产品纯度高,工艺操作简便,原料易得,废水成分简单对环境相对友好,适宜工业化生产.

专利信息

专利号:WO-2023225524-A1
优先权日:2022-05-17
标题:Preparation of highly concentrated mrna
发明人：GENG MARK; SINOIMERI JAMES
权利人:MODERNATX INC
摘要:Provided herein are compositions of highly concentrated mRNA and related methods for preparation and use of the compositions as mRNA process intermediates in the synthesis of therapeutic and prophylactic mRNA formulations.

专利号:US-7902383-B2
优先权日:2006-05-29
标 题 :Production method of heterocyclic mercapto compound
发明人：YOROZUYA SHINICHI; AOKI HIDEMASA
权利人:SHOWA DENKO KK
摘要:A method of the invention industrially produces heterocyclic mercapto compounds useful as raw materials or intermediates in the synthesis of medicaments or pesticides, or as permanent wave agent, with a high yield and high productivity using easily available starting materials. A heterocyclic mercapto compound represented by Formula (1) (wherein X represents any structure of —O—, —S—, —NH—, and —NR 1 —; R 1 represents any of an alkyl group, alkoxy group and alkoxyalkyl group each having 1 to 6 carbon atoms; Y represents an oxygen atom, a sulfur atom or —NR 2 —; R 2 represents a hydrogen atom or alkyl group having 1 to 6 carbon atoms; and Z 1 represents a divalent organic residue having at least one mercapto group) is produced by reacting a metal sulfide or a metal hydrosulfide with a compound represented by Formula (2) (wherein X and Y are as defined in Formula (1); and Z 2 represents a divalent organic residue having at least one halogen group) in the presence of a solvent at a pH of 7.0 to 11.0.

专利号:EP-1764415-A1
优先权日:2005-09-20
标 题 :Microbial production of p-hydroxybenzyl alcohol
发明人：VAN DER WERF MARIA JOHANNA
权利人:TNO
摘要:The invention relates to the production of aromatic compounds, in particular to the synthesis of aromatic compounds that are hydroxylated at the p (para)- or 4-position, such as p-hydroxybenzyl alcohol (p-HBA). Provided is a method for providing p-HBA, comprising the steps of providing a host cell which has an increased flux in the biosynthesis of at least one aromatic amino acid, allowing said host cell to produce p-HBA and isolating said p-HBA. The (recombinant) host cell is for example a bacterial cell which shows an increased production level of L-phenylalanine and/or L-tyrosine.

专利号:US-6992189-B2
优先权日:2002-03-29
标 题 :Synthesis of piperidine and piperazine compounds as CCR5 antagonists
发明人：LEONG WILLIAM; CHEN MINZHANG; D SA BOSCO A; ZHU MAN; XIAO TONG; SHI XIONGWEI; TANG SUHAN; GALA DINESH; GOODMAN ANDREW J; NIELSEN CHRISTOPHER M; LEE GARY M; GAMBOA JUAN A; JONES ANDREW D
权利人:SCHERING CORP
摘要:In its several embodiments, this invention discloses novel processes to prepare the compounds of formula II and formula IV:

专利号:US-2013004979-A1
优先权日:2010-06-11
标 题 :Glycosyltransferase reversibility for sugar nucleotide synthesis and microscale scanning
发明人：THORSON JON S; GANTT RICHARD W; PELTIER-PAIN PAULINE MARIE JEANNE
权利人:WISCONSIN ALUMNI RES FOUND; THORSON JON S; GANTT RICHARD W; PELTIER-PAIN PAULINE MARIE JEANNE
摘要:The present invention generally relates to materials and methods for exploiting glycosyltransferase reversibility for nucleotide diphosphate (NDP) sugar synthesis. The present invention provides engineered glycosyltransferase enzymes characterized by improved reaction reversibility and expanded sugar donor specificity as compared to corresponding non-mutated glycosyltransferase enzymes. Such reagents provide advantageous routes to NDP sugars for subsequent use in a variety of biomedical applications, including enzymatic and chemo-enzymatic glycorandomization.

专利号:US-9018249-B2
优先权日:2011-09-13
标题 :SGLT inhibitors
发明人：JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; NANDA GURMEET KAUR; THUNGATHURTHI SASTRY V R S; SINGH NISHAN; SHARMA SUDHIR KUMAR
权利人:JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; NANDA GURMEET KAUR; THUNGATHURTHI SASTRY V R S; SINGH NISHAN; SHARMA SUDHIR KUMAR; PANACEA BIOTEC LTD
摘要:The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of Formula I and methods of treating or preventing one or more conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2).